WAKO, Hiroshi

J-GLOBAL         Last updated: Nov 28, 2019 at 02:51
WAKO, Hiroshi
Waseda University
Faculty of Social Sciences School of Social Sciences
Job title
Dr. of Science(Waseda University)
Research funding number

Research Areas


Academic & Professional Experience

Cornell University, Post-doctoral associate
Waseda University, Research Assistant
Juntendo University, Research Assistant
Waseda University, Lecturer
Waseda University, Assistant Professor


Department of Physics, Faculty of Science and Engineering, Waseda Universsity
Physics and Applied Physics, Graduate School, Division of Science and Engineering, Waseda University

Published Papers

Kinjo, Akira R.; Bekker, Gert Jan; Wako, Hiroshi; Endo, Shigeru; Tsuchiya, Yuko; Sato, Hiromu; Nishi, Hafumi; Kinoshita, Kengo; Suzuki, Hirofumi; Kawabata, Takeshi; Yokochi, Masashi; Iwata, Takeshi; Kobayashi, Naohiro; Fujiwara, Toshimichi; Kurisu, Genji; Nakamura, Haruki
Protein Science   27(1) 95-102   Jan 2018
© 2017 The Authors Protein Science published by Wiley Periodicals, Inc. on behalf of The Protein Society The Protein Data Bank Japan (PDBj), a member of the worldwide Protein Data Bank (wwPDB), accepts and processes the deposited data of experimen...
Wako, Hiroshi; Endo, Shigeru
Biophysical Reviews   9(6) 877-893   Dec 2017
© 2017, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany. Normal mode analysis (NMA) can facilitate quick and systematic investigation of protein dynamics using data from the Protein Data Bank (PDB). We ...
Characterization of protein folding by a Φ-value calculation with a statistical-mechanical model
Wako Hiroshi;Abe Haruo
Biophysics and Physicobiology   13(0) 263-279   2016
<p>The Φ-value analysis approach provides information about transition-state structures along the folding pathway of a protein by measuring the effects of an amino acid mutation on folding kinetics. Here we compared the theoretically calculated Φ ...
Memorial Issue for Professor Nobuhiko Saitô
Yura Kei;Wako Hiroshi
Biophysics and Physicobiology   13(0) 243-243   2016
Calculation of Free-Energy Profiles, Folding Rates, and Ö Values by Means of a Simple Statistical-Mechanical Model of Protein Folding
H. Wako and H. Abe
Advances in Protein Folding Research/ Nova Science Publisher   19-63   2015

Books etc

Study of Folding/Unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding
H. Wako and H. Abe
Nova Biomedical   Jan 2011   ISBN:978-1-61761-922-9
トポロジーデザイニング 新しい幾何学からはじめる物質・材料設計(分担執筆): 「タンパク質のモチーフ構造解析 」
輪湖 博
(株)エヌ・ティー・エヌ   Apr 2009   ISBN:978-4-86034-162-4
科学技術は社会とどう共生するか(分担執筆): 「科学技術ジャーナリストの課題」(パネルディスカッションの記録)
高橋真理子・渡部潤一・輪湖 博・小山慶太
東京電機大学出版局   Apr 2009   ISBN:978-4-501-62430-9
複雑系の構造と予測 (分担執筆): 「タンパク質分子の立体構造転移」
輪湖 博、安部晴男
共立出版   Jun 2006   
バイオインフォマティクス事典 (分担執筆): 「構造エネルギー最適化法」「基準振動解析」の項目
輪湖 博
共立出版   Jun 2006   

Conference Activities & Talks

Development and Releasing of New Databases forProtein Dynamics: ProMode-Oligomer and ProMode-Elastic.
8 Nov 2011   
Characterization of a conformational change of protein with elastic-network-model based normal mode analysis in dihedral angle space.
17th International Biophysics Congress   31 Oct 2011   
Conformational change reproduced by a linear combination of displacement vectors obtained from normal mode analysis
18 Sep 2011   
Structure deviation analyses of proteins complexed with various ATP analogs.
InCob 2010   26 Sep 2010   
ProMode-Elastic: database of elastic-network-model based normal mode analysis
InCob 2010   26 Sep 2010   

Research Grants & Projects

Normal mode analysis of proteins using an elastic network model in dihedral angle space
Analyses of binding normal modes in protein complexes and registration to the database ProMode
When an internal coordinate as a dihedral angle is used as the degree of freedom of a molecule, a decrease of the number of variables is favorable to calculation of normal modes in the molecule. However the normal mode analysis for a system of mul...
A comparative study of dynamic structures of proteins by using normal mode analysis database.
In this study we considered that a comparative study of normal mode analysis for wild-type and mutant lysozymes and for several proteins in the same superfamily could provide some valuable information about dynamic structures of proteins.1.In the ...
The dynamic structure of protein molecules based on coupling among normal modes
This research aims to investigate complicated motions of a protein systematically by the molecular dynamics with the initial velocity in the direction of each normal mode of a protein molecule from the viewpoint that linear movement of normal mode...
Classification and analysis of local structure motifs in protein conformations
In order to reveal a principal of protein architectures we identified local structure motifs commonly found in different protein conformations and analyzed them. For this purpose we used the method developed by ourselves, in which Delaunay tessell...