2013年
Discovery of a novel type of autophagy targeting RNA
Autophagy
- 巻
- 9
- 号
- 3
- 開始ページ
- 403
- 終了ページ
- 409
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4161/auto.23002
- 出版者・発行元
- Taylor and Francis Inc.
Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into lysosomes for degradation. This pathway, which we term 'RNautophagy,' is ATP-dependent, and unlike CMA, is independent of HSPA8/ Hsc70. LAMP2C, a lysosomal membrane protein, serves as a receptor for this pathway. The cytosolic tail of LAMP2C specifically binds to almost all total RNA derived from mouse brain. The cytosolic sequence of LAMP2C and its affinity for RNA are evolutionarily conserved from nematodes to humans. Our findings shed light on the mechanisms underlying RNA homeostasis in higher eukaryotes. © 2013 Landes Bioscience.
- リンク情報
- ID情報
-
- DOI : 10.4161/auto.23002
- ISSN : 1554-8635
- ISSN : 1554-8627
- SCOPUS ID : 84876222448