TAKIKAWA Hajime

J-GLOBAL         Last updated: Jun 22, 2019 at 13:49
 
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Name
TAKIKAWA Hajime
Affiliation
Teikyo University
Section
Faculty of Medical Technology
Job title
Professor
Degree
(BLANK)(The University of Tokyo)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
Apr 2018
 - 
Today
Emeritus Professor, School od Meicine, Teikyo University
 
Apr 2018
 - 
Today
Dean, Faculty of Medical Technology, Teikyo University
 
1990
 - 
1998
Department of Medicine, Teikyo University School
 
1998
   
 
- Department of Medicine, Teikyo University School
 
1987
 - 
1990
Department of Medicine, Teikyo University School
 

Education

 
 
 - 
1977
Faculty of Medicine, The University of Tokyo
 

Published Papers

 
Clinical practice guidelines for IgG4-related sclerosing cholangitis
Kamisawa T, Nakazawa T, Tazuma S, Zen Y, Tanaka A, Ohara H, Muraki T, Inui K, Inoue D, Nishino T, Naitoh I, Itoi T, Notohara K, Kanno A, Kubota K, Hirano K, Isayama H, Shimizu K, Tsuyuguchi T, Shimosegawa T, Kawa S, Chiba T, Okazaki K, Takikawa H, Kimura W, Unno T, Yoshida M
J Hepatobiliary Pancreat Sci   26 9-42   Jan 2019   [Refereed]
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.
Hitomi Y, Ueno K, Kawai Y, Nishida N, Kojima K, Kawashima M, Aiba Y, Nakamura H, Kouno H, Kouno H, Ohta H, Sugi K, Nikami T, Yamashita T, Katsushima S, Komeda T, Ario K, Naganuma A, Shimada M, Hirashima N, Yoshizawa K, Makita F, Furuta K, Kikuchi M, Naeshiro N, Takahashi H, Mano Y, Yamashita H, Matsushita K, Tsunematsu S, Yabuuchi I, Nishimura H, Shimada Y, Yamauchi K, Komatsu T, Sugimoto R, Sakai H, Mita E, Koda M, Nakamura Y, Kamitsukasa H, Sato T, Nakamuta M, Masaki N, Takikawa H, Tanaka A, Ohira H, Zeniya M, Abe M, Kaneko S, Honda M, Arai K, Arinaga-Hino T, Hashimoto E, Taniai M, Umemura T, Joshita S, Nakao K, Ichikawa T, Shibata H, Takaki A, Yamagiwa S, Seike M, Sakisaka S, Takeyama Y, Harada M, Senju M, Yokosuka O, Kanda T, Ueno Y, Ebinuma H, Himoto T, Murata K, Shimoda S, Nagaoka S, Abiru S, Komori A, Migita K, Ito M, Yatsuhashi H, Maehara Y, Uemoto S, Kokudo N, Nagasaki M, Tokunaga K, Nakamura M
Sci Rep   9 102   Jan 2019   [Refereed]
An analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan.
Aiso M, Takikawa H, Tsuji K, Kagawa T, Watanabe M, Tanaka A, Sato K, Sakisaka S, Hiasa Y, Takei Y, Ohira H, Ayada M, Hashimoto E, Kaneko S, Ueno Y, Ohmoto K, Takaki A, Torimura T, Matsuzaki Y, Tajiri K, Yoneda M, Ito T, Kato N, Ikejima K, Mochida S, Yasuda H, Sakamoto N
Hepatol Res   49 105-110   Jan 2019   [Refereed]
Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey.
Takahashi A, Moriya K, Ohira H, Arinaga-Hino T, Zeniya M, Torimura T, Abe M, Takaki A, Kang JH, Inui A, Fujisawa T, Yoshizawa K, Suzuki Y, Nakamoto N, Koike K, Yoshiji H, Goto A, Tanaka A, Younossi ZM, Takikawa H
PLoS One   13 E0204772   Oct 2018   [Refereed]
Is patient-reported outcome improved by nalfurafine hydrochloride in patients with primary biliary cholangitis and refractory pruritus? A post-marketing, single-arm, prospective study.
Yagi M, Tanaka A, Abe M, Namisaki T, Yoshiji H, Takahashi A, Ohira H, Komori A, Yamagiwa S, Kikuchi K, Yasunaka T, Takaki A, Ueno Y, Honda A, Matsuzaki Y, Takikawa H
Sci Rep   22 12542   Sep 2018   [Refereed]
Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey.
Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep NC, Tsuneyama K, Kage M, Nakano M, Kang JH, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H
J Gastroenterol   53 1079-1088   2018   [Refereed]
Clinical Guidelines for Primary Sclerosing Cholangitis 2017
Isayama H, Tazuma S, Kokudo N, Tanaka A, Tsuyuguchi T, Nakazawa T, Notohara K, Mizuno S, Akamatsu N, Serikawa M, Naitoh I, Hirooka Y, Wakai T, Itoi T, Ebata T, Okaniwa S, Kamisawa T, Kawashima H, Kanno A, Kubota K, Tabata M, Unno M, Takikawa H
J Gastroenterol   53 1006-1034   2018   [Refereed]
Effect of deferred or no treatment with ursodeoxycholic acid in patients with early primary biliary cholangitis.
Tanaka A, Hirohara J, Nakano T, Yagi M, Namisaki T, Yoshiji H, Hakanuma Y, Takikawa H
48 727-734   2018   [Refereed]
Nonalcoholic fatty liver disease in patients with autoimmune hepatitis.
Takahashi A, Arinaga-Hino T, Ohira H, Abe K, Torimura T, Zeniya M, Abe M, Yoshizawa K, Takaki A, Suzuki Y, Kang J-H, Nakamoto N, Fujisawa T, Tanaka A, Takikawa H
JGH Open   2 54-58   2018   [Refereed]
Factors influencing cancer patients’ choice of end-of-life care place.
Natsume M, Watanabe K, Matsumoto S, Naruge D, Hayashi K, Furuse J, Kawamura M, Jinno H, Sano K, Fukushima R, Osawa C, Aruga E, Hashiguchi Y, Tanaka A, Takikawa H, Seki N
J Palliat Med   21 751-765   2018   [Refereed]
The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.
Mawatari S, Moriuchi A, Ohba F, Kawano T, Oda K, Takikawa Y, Takikawa H, Ido A, Tsubouchi H
J Gastroenterol   53 861-872   2018   [Refereed]
A proposed severity classification system for hepatolithiasis based on an analysis of prognostic factors in a Japanese patient cohort
Suzuki, Y, Mori T, Yokoyama M, Kim S, Momose H, Matsuki R, Kogure M, Nakazato T, Abe N, Isayama H, Nakazawa T, Notohara K, Tanaka A, Tsuyuguchi T, Tazuma S, Takikawa H, Sugiyama M.
J Gastroenterol   53 854-860   2018   [Refereed]
Nationwide survey for acute liver failure and late-onset hepatic failure in Japan
Nakao M, Nakayama N, Uchida Y, Tomiya T, Ido A, Sakaida I, Yokosuka O, Takikawa Y, Inoue K, Genda T, Shimizu M, Terai S, Tsubouchi H, Takikawa H, Mochida S
J Gastroenterol   53 752-769   2018   [Refereed]
Mochida S, Nakayama N, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa H
Hepatol Res   48 303-312   2018   [Refereed]
Nakayama N, Uemura H, Uchida Y, Tomiya T, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa H, Mochida S
Hepatol Res   48 303-312   2018   [Refereed]
Sogo T, Takahashi A, Inui A, Fujisawa T, Ohira H, Takikawa H
Hepatol Res   48 186-294   2018   [Refereed]
Uetake H, Sugihara K, Muto K, Sunaya T, Horiuchi-Yamamoto Y, Takikawa H
Clin Colorect Cancer   17 e49-e58   2018   [Refereed]
Tanaka A, Tazuma S, Nakazawa T, Isayama H, Tsuyuguchi T, Inui K, Takikawa H
Journal of hepato-biliary-pancreatic sciences   24(4) 217-225   Apr 2017   [Refereed]
Acute presentation of autoimmune hepatitis: a multicenter study with detailed histologic evaluation in a large cohort of patients
Hiep NC, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang J-H, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H
J Clin Pathol   70 961-969   2017   [Refereed]
Nakazawa T, Notohara K, Tazuma S, Tanaka A, Isayama H, Tsuyuguchi T, Mori T, Takikawa H
J Gastroenterol   52 838-844   2017   [Refereed]
Tanaka A, Tazuma S, Okazaki K, Nakazawa T, Inui K, Chiba T, Takikawa H
Clin Gastroenterol Hepatol   15 920-926   2017   [Refereed]
Takahashi A, Arinaga-Hino T, Ohira H, Torimura T, Zeniya M, Abe M, Yoshizawa K, Takaki A, Suzuki Y, Kang JH, Nakamoto N, Fujisawa T, Yonemoto K, Tanaka A, Takikawa H
J Gastroenterol   52 631-640   2017   [Refereed]
Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population
Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M, Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M
Hum Mol Genet   26 650-659   2017   [Refereed]
Aiso M, Yagi M, Tanaka A, Miura K, Miura R, Arizumi T, Takamori Y, Nakahara S, Maruo Y, Takikawa H
Intern Med   56 661-664   2017   [Refereed]
Tanaka A, Ma X, Yokosuka O, Weltman M, You H, Amarapurkar DN, Kim YJ, Abbas Z, Payawal DA, Chang ML, Efe C, Ozaslan E, Abe M, Mitchell-Thain R, Zeniya M, Han KH, Vierling JM, Takikawa H
Hepatol Int   10 909-915   2016   [Refereed]
Mochida S, Nakao M, Nakayama N, Uchida Y, Nagoshi S, Ido A, Mimura T, Harigai M, Kaneko H, Kobayashi H, Tsuchida T, Suzuki H, Ura N, Nakamura Y, Bessho M, Dan K, Kusumoto S, Sasaki Y, Fujii H, Suzuki F, Ikeda K, Yamamoto K, Takikawa H, Tsubouchi H, Mizokami M
J Gastroenterol   51 999-1010   2016   [Refereed]
Tanaka A, Takikawa H, Mochida S, Koike K, Miwa H, Shimosegawa T
J Gastroenterol   51 748-749   2016   [Refereed]
Mochida S, Nakayama N, Ido A, Takikawa Y, Yokosuka O, Sakaida I, Moriwaki H, Genda T, Takikawa H
Hepatol Res   446 369-371   2016   [Refereed]
Tanaka A, Kikuchi K, Miura R, Miura K, Mikami M, Aiso M, Takamori Y, Takikawa H
Hepatol Res   46 E45-E50   2016   [Refereed]
Asahina Y, Izumi N, Hiromitsu K, Kurosaki M, Koike K, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Hayashi N, Hiramatsu N, Yotsuyanagi H
Hepatol Res   46 129-165   2016   [Refereed]
Fujiwara K, Yokosuka O, Inoue K, Yasui S, Abe R, Oda S, Arata S, Takikawa Y, Ido A, Mochida S, Tsubouchi H, Takikawa H
Hepatol Res   46 10-12   2016   [Refereed]
Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H
Hepatology research : the official journal of the Japan Society of Hepatology   45(8) 846-855   Aug 2015   [Refereed]
Tanaka A, Hirohara J, Nakanuma Y, Tsubouchi H, Takikawa H
Journal of gastroenterology   50(6) 675-682   Jun 2015   [Refereed]
Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H
Journal of hepato-biliary-pancreatic sciences   22(3) 230-236   Mar 2015   [Refereed]
Adachi M, Tanaka A, Aiso M, Takamori Y, Takikawa H
Hepatol Res   45 1299-1306   2015   [Refereed]
Abe K, Miki A, Okamura T, Shimada K, Yamamoto T, Aiso M, Tanaka A, Kita H, Kuyama Y, Takikawa H
Clinical journal of gastroenterology   7(6) 506-509   Dec 2014   [Refereed]
Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H, Intractable Hepato-Biliary Disease Study Group of Japan.
Hepatology research : the official journal of the Japan Society of Hepatology   44(13) 1299-1307   Dec 2014   [Refereed]
Hayashi H, Naoi S, Inoue T, Tanigawa Igarashi K, Nagasaka H, Kage M, Takikawa H, Sugiyama Y, Inui A, Kusuhara H.
J Pediatr   164(5) 1219-1227   May 2014   [Refereed]
Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H
Journal of hepato-biliary-pancreatic sciences   21(1) 43-50   Jan 2014   [Refereed]
JSH guidelines for the management of hepatitis B virus infection.
Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka Y, Tsubouchi H, Yotsuyanagi H.
Hepatol Res   44(suppl.1) 1-58   2014   [Refereed]
JSH guidelines for the management of hepatitis s C virus infection: A 2014 update for genotype 1.
Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka Y, Tsubouchi H, Yotsuyanagi H,
Hepatol Res   44(suppl.1) 59-70   2014   [Refereed]
Guidelines for the management of primary biliary cirrhosis.
Komori A, Tanaka A, Takikawa H, Tsubouchi H, Ishibashi H, Wgawa H, Shirabe K, Harada K, Nakamuta M, Zenia M, Nakamura N, Fukushima N, Shimoda S, Sakisaka S, Morizane T, Takeyama Y, Nakanuma Y, Ueno Y.
Hepatol Res   44(suppl.1) 71-90   2014   [Refereed]
A national survey for primary sclerosing cholangitis and IgG4-related sclerosing cholangitis in Japan.
Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H.
J Hepatobiliary Pncreat Sci   21 43-50   2014   [Refereed]
Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis.
Miura K, Tanaka A, Adachi M, Yamamoto T, Takikawa H.
Intern Med   53(10) 1037-1042   2014   [Refereed]
Tanaka A, Takikawa H
Journal of autoimmunity   46 35-40   Oct 2013   [Refereed]
Honda A, Ikegami T, Nakamuta M, Miyazaki T, Iwamoto J, Hirayama T, Saito Y, Takikawa H, Imawari M, Matsuzaki Y
Hepatology (Baltimore, Md.)   57(5) 1931-1941   May 2013   [Refereed]
Revision of the training curriculum of Japan Society of Gastroenterology.
Ishibashi H, Takikawa H, Nakao A, Watanabe M, Niwa Y, Nakamura T, Hokari R, Fukuzawa Y, Motoo Y, Morizane T, Sugano K
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   110(5) 788-795   May 2013   [Refereed]
Kumagai A, Fukushima J, Takikawa H, Fukuda T, Fukusato T
Hepatology research : the official journal of the Japan Society of Hepatology   43 959-969   Jan 2013   [Refereed]
Guidelines for the management of hepatitis C virus infection. First edition, May 2012, The Japan Society of Hepatology.
Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tsubouchi H, Yotsuyanagi H.
Hepatol Res   43 1-34   2013   [Refereed]
Identification of a novel HLA-B allele HLA-B*07:185 in a Japanese individual.
Maekawa K, Futagami T, Kusunoki Y, Matsuzaki Y, Takikawa H.
Tissure Antigens   8/2 434-436   2013   [Refereed]
Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H
American journal of human genetics   91 721-728   Oct 2012   [Refereed]
Ohara H, Okazaki K, Tsubouchi H, Inui K, Kawa S, Kamisawa T, Tazuma S, Uchida K, Hirano K, Yoshida H, Nishino T, Ko SB, Mizuno N, Hamano H, Kanno A, Notohara K, Hasebe O, Nakazawa T, Nakanuma Y, Takikawa H, Research Committee of IgG4-related Diseases, Research Committee of Intractable Diseases of Liver and Biliary Tract, Ministry of Health,Labor and Welfare,Japan, Japan Biliary Association
Journal of hepato-biliary-pancreatic sciences   19(5) 536-542   Sep 2012   [Refereed]
Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
PloS one   7 e37803   2012   [Refereed]
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
TAKIKAWA Hajime
J Hepatol   56 1136-1144   2012   [Refereed]
Characterization of urinary bile acids in a pediatric BRIC-1 patient: Effect of rifampicin treatment.
Mizuochi T, Kimura A, Tanaka A, Muto A, Nittono H, Seki Y, Takahashi T, Kurosawa T, Kage M, Takikawa H, Matsuishi T.
Clin Chim Acta   413 1301-1304   2012   [Refereed]
Mitamura K, Hori N, Iida T, Suzuki M, Shimizu T, Nittono H, Takaori K, Takikawa H, Hofmann AF, Ikegawa S
Steroids   76(14) 1609-1614   Dec 2011   [Refereed]
Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT Study Group
Hepatology research : the official journal of the Japan Society of Hepatology   41(10) 955-964   Oct 2011   [Refereed]
Fukami M, Tanka A, Takikawa H
Journal of hepato-biliary-pancreatic sciences   18(5) 684-688   Sep 2011   [Refereed]
Tanaka A, Harada K, Ebinuma H, Komori A, Yokokawa J, Yoshizawa K, Abe M, Miyake Y, Kikuchi K, Ohira H, Zeniya M, Yamamoto K, Ishibashi H, Onji M, Nakanuma Y, Tsubouchi H, Takikawa H
Hepatology research : the official journal of the Japan Society of Hepatology   41 877-886   Sep 2011   [Refereed]
Miura R, Tanaka A, Takikawa H
Hepatology research : the official journal of the Japan Society of Hepatology   41(4) 358-363   Apr 2011   [Refereed]
Montali L, Tanaka A, Riva P, Takahashi H, Cocchi C, Ueno Y, Miglioretti M, Takikawa H, Vecchio L, Frigerio A, Bianchi I, Jorgensen R, Lindor KD, Podda M, Invernizzi P, Italian-Japanese PBC Study Group
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   42 718-723   Oct 2010   [Refereed]
Nagasaka H, Yorifuji T, Kobayashi K, Takikawa H, Komatsu H, Inui A, Fujisawa T, Miida T, Tsukahara H, Takatani T, Hayashi H
Molecular genetics and metabolism   100(2) 123-128   Jun 2010   [Refereed]
Goto H, Takikawa H
Hepatology research : the official journal of the Japan Society of Hepatology   40(5) 524-529   May 2010   [Refereed]
Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT Study Group
Hepatology research : the official journal of the Japan Society of Hepatology   40(2) 135-144   Feb 2010   [Refereed]
Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H
Internal medicine (Tokyo, Japan)   49(23) 2577-2582   2010   [Refereed]
Drug-induced liver injury in Japan – an analysis of 1,676 cases between 1997 and 2006.
Takikawa H, Murata Y, Horiike N, Fukui H, Onji M.
Hepatol Res   39 427-431   2009   [Refereed]
Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo.
Kitazume S, Oka R, Ogawa K, Futakawa S, Hagiwara Y, Takikawa H, Kato M, Kasahara A, Miyoshi E, Taniguchi N,
Glycobiology   19 479-487   2009   [Refereed]
Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in both Japanese and Italian populations.
Tanaka A, Nezu S, Uegaki S, Kikuchi K, Shibuya A , Miyakawa H, Takahashi
J Hepatol   50 1202-1209   2009   [Refereed]
Urinary bile acid sulfate levels in patients with hepatitis C virus-related chronic liver diseases.
Negoro S, Tanaka A, Takikawa H.
Hepatol Res   39 760-765   2009   [Refereed]
Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis.
Miura F, Asano T, Amano H, Yoshida M, Toyota N, Wada K, Kato K, Takada T, Fukushima J, Kondo F, Takikawa H.
World J Gastroenterol   15 1394-1397   2009   [Refereed]
Recent status of drug-induced liver injury.
TAKIKAWA Hajime
Hepatol Res   39 1-6   2009   [Refereed]
Effect of genipin on the biliary excretion of cholephilic compounds in rats.
Mikami M, Takikawa H.
Liver Int   38 614-621   2008   [Refereed]
Successful treatment with colestimide for a bout of cholestasis in a Japanese patient with benign recurrent intrahepatic cholestasis caused by ATP8B1 mutation.
Uegaki S, Tanaka A, Mori Y, Kodama H, Fukusato T, Takikawa H.
Intern Med   47 599-602   2008   [Refereed]
Gene expression profiling in whole liver of bile duct ligated rats. VEGF-A expression is upregulated in hepatocytes adjacent to the portal tract
Tanaka A, Tsuneyama K, Mikami M, Uegaki S, Aiso M, Takikawa H.
J Gastroenterol Hepatol   22 1993-2000   2007   [Refereed]
Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients of chronic hepatitis C.
Tanaka A, Uegaki S, Kurihara H, Aida K, Mikami M, Nagashima I, Shiga J, Takikawa H.
World J Gastroenterol   13 5180-5187   2007   [Refereed]
Characteristic of primary sclerosing cholangitis in Japan.
Takikawa H
37 S438-S441   2007   [Refereed]
Liver injury induced by levothyroxine in a patient with primary hyperthyroidism.
Kawakami T, Tanaka A, Negoro S, Morisawa Y, Mikami M, Hojo M, Yamamoto T, Uegaki S, Aiso M, Kawasaki T, Ishii T, Kuyama Y, Fukusato T, Takikawa H. Liver injury induced by levothyroxine in a patient with primary hyperthyroidism.
Intern Med   46 1105-1108   2007   [Refereed]
Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis.
Nagasaka H, Chiba H, Hui SP, Takikawa H, Miida T, Takayanagi M, Yorifuji T, Hasegawa M, Ota A, Hirano K, Kikuchi H, Tsukahara H, Kobayashi K.
J Pediatr Gastroenterol Nutr   45 96-105   2007   [Refereed]
Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats.
Sasamoto T, Sano N, Takikawa H.
J Gastroenterol Hepato   21 26-31   2006   [Refereed]
Drug-induced liver injury by dietary supplements in Japan.
TAKIKAWA Hajime
JMAJ   49 327-329   2006   [Refereed]
Primary hepatic somatostatinoma in a patient with von Reckringhousen disease.
Morisawa Y, Tanaka A, Yamamoto T, Uegaki S, Takamori Y, Ishii T, Kuyama Y, Fukusato T, Shiga J, Takikawa H.
J Gastroenterol   41 389-391   2006   [Refereed]
Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats.
Hepatol Res   34 193-198   2006   [Refereed]

Misc

 
Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver.
Journal of Biological Chemistry   265 2132-2136   1990
Cyclical oxidation-reduction of the C3 position of bileacids catalyzed by rat hepatic 3α-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isolated rat hepatocytes,
Journal of Clinical Investigation   80 852-860   1987
Cyclical oxidation-reduction of the C3 position of bile acids catalysed by 3α-hydroxysteroid dehydrogenase II. Studies in the prograde and retrograde single-poss, perfused rat liver an
Journal of Clinical Investigation   80 861-866   1987
Glucuronidation of bile acids by their high-dose infusion into rats
Hepatology   13(1) 122-1226   1991
Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat
Hepatology   14 352-360   1991

Conference Activities & Talks

 
Characteristics of PSC in Japan. Symposium "PSC, a disease of omnifarious features and pathogenesis"
Takikawa H.
th JSH Single Topic Conference "Liver and Immune Disorder: New Insights from Pathogenesis to Treatment"   30 Sep 2006   

Research Grants & Projects

 
Bile acid metabolism
Hepatic transport
Cholestasis