HIROHATA Shunsei

J-GLOBAL         Last updated: Jun 26, 2012 at 19:26
 
Avatar
Name
HIROHATA Shunsei
Affiliation
Kitasato University
Section
School of Medicine Faculty of Medicine
Job title
Associate Professor
Degree
(BLANK)(The University of Tokyo)

Profile

I have been studying Neuro-Behcet's disease and neuropsychiatric systemic lupus erythematodes.

Research Areas

 
 

Education

 
 
 - 
1980
Faculty of Medicine, The University of Tokyo
 

Published Papers

 
Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y
Modern rheumatology / the Japan Rheumatism Association   22(3) 405-413   Jun 2012   [Refereed]
Hashimoto A, Endo H, Kondo H, Hirohata S
Modern rheumatology / the Japan Rheumatism Association   22 272-279   Apr 2012   [Refereed]
Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, Ogura T, Mizusawa H, Imai T, Miyasaka N, Nanki T
Arthritis research & therapy   14 R48   Mar 2012   [Refereed]
Arinuma Y, Kikuchi H, Aramaki K, Kyogoku M, Hirohata S
Modern rheumatology / the Japan Rheumatism Association   21(5) 509-513   Oct 2011   [Refereed]
Hirohata S, Nagai T, Asako K, Tomita T, Yoshikawa H
Clinical immunology (Orlando, Fla.)   140(3) 276-283   Sep 2011   [Refereed]

Misc

 
Hirohata S
Nature clinical practice. Rheumatology   2 358-359   Jul 2006   [Refereed]
T cell-dependent activation of B cell proliferation and differentation by immobilized monoclonal antibodies to CD3.
Journal of Immunotology   140(11)    1988
Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement.
Arthritis and Rheumatism   33(5)    1990
Frequency analysis of human peripheral blood B cells producing IgM-rheumatoid factor.
Journal of Immunotology   145(6)    1990
Cerebrospinal fluid IgM, IgA, and IgG index systemic lupus erythematosus.
Archive of Internal Medicine   145(10)    1985

Books etc

 
Abnormal T cell responses to bacterial antigens in patients with Behcet's disease
Behcet's Disease Elsevier Science Publishers B. V.   1993   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Shunsei HIROHATA
In the current studies, we first demonstrated that cerebrospinal fluid anti-NR2 levels were significantly higher in patients with lupuspsychosis than in control groups, suggesting that anti-NR2 antibodies might play a pivotalrole in the pathogenes...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Shunsei HIROHATA
It has been demonstrated that the epitopes of ribosomal P proteins are present on the surface of human neuroblastoma cells. We explored the relationship of antibodies to the whole ribosomal P proteins (P0, P1, P2) in cerebrospinal fluid (CSF) with...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2003    Investigator(s): Shunsei HIROHATA
Like IL-12, IFN-α has been found to play an important role in human Th1 responses. Whereas IL-12 enhances CD154 expression on human T cells, the effect of IFN-α has not been elucidated. The present study examined the effects of IFN-α on CD154 expr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): Shunsei HIROHATA
We examined the presence of the epitope recognized by antiribosomal P protein antibody (anti-P) on the cell surface of human immunocompetent cells in order to delineate its role in the pathogenesis of CNS lupus. Highly purified CD4+ and GD8+ T cel...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Shunsei HIROHATA
Although human T cells have been shown to regulate humoral immune responses by directly inhibiting B cells, the precise sequelae for the mechanism of suppression have not yet been delineated. The present study therefore examined the nature of T ce...