2000年2月
Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra
Journal of Pharmacy and Pharmacology
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- 巻
- 52
- 号
- 2
- 開始ページ
- 219
- 終了ページ
- 223
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1211/0022357001773724
- 出版者・発行元
- ROYAL PHARMACEUTICAL SOC GREAT BRITAIN
Isoflavan derivatives, glabridin (1), hispaglabridin A (2), hispaglabridin B (3), 4'-O-methylglabridin (4) and 3'-hydroxy-4'-O-methylglabridin (5), isolated from Glycyrrhiza glabra, were investigated for their ability to protect liver mitochondria against oxidative stresses.
Mitochondrial lipid peroxidation linked to respiratory electron transport and that induced non-enzymatically were inhibited by these isoflavans. Hispaglabridin A (2) strongly inhibited both peroxidations and 3'-hydroxy-4'-O-methylglabridin (5) was the most effective at preventing NADH-dependent peroxidation. 3'-Hydroxy-4'-O-methylglabridin (5) protected mitochondrial respiratory enzyme activities against NADPH-dependent peroxidation injury. Dihydroxyfumarate-induced mitochondrial peroxidation was also prevented by this isoflavan.
Isoflavans from G. glabra were shown to be effective in protecting mitochondrial function against oxidative stresses.
Mitochondrial lipid peroxidation linked to respiratory electron transport and that induced non-enzymatically were inhibited by these isoflavans. Hispaglabridin A (2) strongly inhibited both peroxidations and 3'-hydroxy-4'-O-methylglabridin (5) was the most effective at preventing NADH-dependent peroxidation. 3'-Hydroxy-4'-O-methylglabridin (5) protected mitochondrial respiratory enzyme activities against NADPH-dependent peroxidation injury. Dihydroxyfumarate-induced mitochondrial peroxidation was also prevented by this isoflavan.
Isoflavans from G. glabra were shown to be effective in protecting mitochondrial function against oxidative stresses.
- リンク情報
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- DOI
- https://doi.org/10.1211/0022357001773724
- CiNii Articles
- http://ci.nii.ac.jp/naid/80011559586
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10714953
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000085638200012&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1211/0022357001773724
- ISSN : 0022-3573
- CiNii Articles ID : 80011559586
- PubMed ID : 10714953
- Web of Science ID : WOS:000085638200012