高野達哉 (Tatsuya Takano) - マイポータル - researchmap

基本情報

所属: 旧所属帝京大学薬学部薬学科教授

学位: 薬学博士(東京大学)
薬学修士

J-GLOBAL ID: 200901087429831403
researchmap会員ID: 1000093170

研究キーワード

2

研究分野

2

経歴

6

1973年 - 1978年

広島大学医学部薬学科生理化学教室助教授
1978年

- 帝京大学薬学部微生物・病態生化学教室教授
1978年

-
1971年 - 1972年

The Rockefellor University, New York, N. Y. Research Associate
1970年 - 1971年

Baylor College of Medicine, Houston, Texas Research Associate
1965年 - 1969年

東京大学薬学部微生物薬品化学教室助手

学歴

4

委員歴

4

MISC

76

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7

Y Fujimoto, H Itabe, J Sakai, M Makita, J Noda, M Mori, Y Higashi, S Kojima, T Takano

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1644(1) 47-59 2004年2月
Oxidized phosphol lipids in oxidized low density lipoprotein reduce the activity of tissue factor pathway inhibitor through association with its carboxy terminal region.

Antioxidants & Redox Signaling 6(. 705-712) 2004年
Serum high-density lipoprotein-cholesterol levels modify the association between plasma levels of oxidatively modified low-density lipoprotein and coronary artery disease in men

Metabolism 53(. 423-429) 2004年
Minimally modified LDL is an oxidized LDL enriched with oxidized phosphatidylcholines

H Itabe, M Mori, Y Fujimoto, Y Higashi, T Takano

JOURNAL OF BIOCHEMISTRY 134(3) 459-465 2003年9月
Transmembrane lipid transfer is crucial for providing neutral lipids during very low density lipoprotein assembly in endoplasmic reticulum

Y Higashi, H Itabe, H Fukase, M Mori, Y Fujimoto, T Takano

JOURNAL OF BIOLOGICAL CHEMISTRY 278(24) 21450-21458 2003年6月
Distribution of microsomal triglyceride transfer protein within sub-endoplasmic reticulum regions in human hepatoma cells

Biochimica at Biophysica Acta 1581; 127-136 2002年
Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis

Noriyuki Sakata, Noriko Uesugi, Shigeo Takebayashi, Ryoji Nagai, Tadashi Jono, Seikoh Horiuchi, Motohiro Takeya, Hiroyuki Itabe, Tatsuya Takano, Theingi Myint …

Cardiovascular Research 49(2) 466-475 2001年2月1日
リポ蛋白代謝の分子機構

日本臨床 2(. 29 36) 2001年
Phosholipids

Nippon Rinsho Feb; 59 Suppl 2;29-36 2001年
Elevated Levels of Oxiclied low Density Lipoprotein Show a Positive Relationship with the Severity of Acute Coronary Syndromes

Circulation 103; 1955-60 2001年
Foam Cell Formation Containing Lipid Clroplets Enriched with free Cholesterol by Hyperliperlipidemic Serum.

J.Lipid Res. Nov; 42(11); 1771-81 2001年
Circulating oxidized low density lipoprotein levels - A biochemical risk marker for coronary heart disease

S Toshima, A Hasegawa, M Kurabayashi, H Itabe, T Takano, J Sugano, K Shimamura, J Kimura, Michishita, I, T Suzuki …

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 20(10) 2243-2247 2000年10月
Preparation of radioactive aldehyde-containing phosphatidylcholine

H Itabe, K Suzuki, R Hosoya, M Mori, Y Higashi, Y Fujimoto, T Takano

ANALYTICAL BIOCHEMISTRY 285(1) 151-155 2000年10月
Lysosomal accumulation of oxidized phosphatidylcholine-apolipoprotein B complex in macrophages: intracellular fate of oxidized low density lipoprotein

H Itabe, K Suzuki, Y Tsukamoto, R Komatsu, M Ueda, M Mori, Y Higashi, T Takano

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1487(2-3) 233-245 2000年9月
Simple and practical sandwich-type enzyme immunoassay for human oxidatively modified low density lipoprotein using antioxidized phosphatidylcholine monoclonal antibody and antihuman apolipoprotein-B antibody

H Kohno, N Sueshige, K Oguri, H Izumidate, T Masunari, M Kawamura, H Itabe, T Takano, A Hasegawa, R Nagai

CLINICAL BIOCHEMISTRY 33(4) 243-253 2000年6月
In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques

Y Imanaga, N Sakata, S Takebayashi, A Matsunaga, J Sasaki, K Arakawa, R Nagai, S Horiuchi, H Itabe, T Takano

ATHEROSCLEROSIS 150(2) 343-355 2000年6月
Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins

Cell Struct. Funct. 25(. 309-315) 2000年
Reduction of sphingomyelin level without accumulation of ceramide in chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-β-cyclodextrin

Journal of Biological chemistry 275(44) 34028-34034 2000年
Oxidized low density lipoprotein : The occurrence and metabolism in circulation and in form cells

Journal of Atherosclerosis and Thrombosis 7(3) 123-131 2000年
Presence of phospholipid-neutral lipid complex structures in atherosclerotic lesions as detected by a novel monoclonal antibody

M Mori, H Itabe, K Takatoku, K Shima, J Inoue, M Nishiura, H Takahashi, H Ohtake, R Sato, Y Higashi …

JOURNAL OF BIOLOGICAL CHEMISTRY 274(35) 24828-24837 1999年8月

もっとみる

書籍等出版物

1

Detection of Oxidized Phosphatidylcholines in Human Atherosclerotic Lesions and in Plasma LDL Fractions.

Pathophysiology of Lipid Peroxides and Related Free Radicals(Yagi, K. , ed. )Japan Sci. Soc. Press 1998年

所属学協会

13

共同研究・競争的資金等の研究課題

2

産業財産権

3