Motoyasu Ohsawa - My portal - researchmap

Profile Information

Affiliation: Research Adviser, Food and Drug Safety Center, Hatano Research Institute
: Professor Emeritus of Teikyo University, Faculty of Pharmaceutical Sciences, Department of Chemistry and Physics, Department of Health Sciences, Teikyo University

Degree: Ph.D.(The University of Tokyo)
M.Pharm.Sci(The University of Tokyo)

J-GLOBAL ID: 200901070459201978
researchmap Member ID: 1000093194

Research Interests

7

Research Areas

4

Research History

16

1988 - 2008

Faculty of Pharma-Science, Teikyo University
1988 - 2008

Teikyo University, Faculty of
2008

-
2008

- 帝京大学名誉教授
2008

Scientific Advisor, Food and Drug Safety Center Japan, Hatano Research Institute
2008

- Teikyo University, Professor Emeritus
1979 - 1988

Faculty of Pharma-Science, Teikyo University
1979 - 1988

Teikyo University, Faculty of Pharmaceutical
1977 - 1979

労働省産業医学総合研究所,主任研究員
1977 - 1979

National Institute of Industrial Health,
1971 - 1977

労働省産業医学総合研究所,研究員
1971 - 1977

National Institute of Industrial Health,
Pharmaceutical Sciences, Professor
Sciences, Associate Professor
Senior Research Fellow
Research Fellow

Education

4

Committee Memberships

10

Awards

1

Sep, 2014

The Japanese Society of Immunotoxicology Award, Immunotoxicity of environmental substances with special reference to heavy metals: Toxicological properties and evaluation, The Japanese Society of Immunotoxicology

OHSAWA Motoyasu

Papers

31

Emerging issues in immunotoxicology evaluation of newly developed pharmaceutical products

OHSAWA Motoyasu

Annual Report of Hatano Research Institute, 39 16-24, Dec, 2016 Peer-reviewed
Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate

Tomoko Shindo, Yukiko Kanazawa, Yoshiaki Saito, Kohichi Kojima, Motoyasu Ohsawa, Reiko Teshima

JOURNAL OF TOXICOLOGICAL SCIENCES, 37(2) 307-315, Apr, 2012 Peer-reviewed
重金属による免疫毒性とその発現機序

大沢基保

YAKUGAKU ZASSHI, 129(3) 305-319, 2009
Analysis of human proteins that have an affinity to heavy metals by metal-chelating column chromatography

Fuminori Otsuka, Miho Komatsu-Okugaito, Shinji Koizumi, Motoyasu Ohsawa

INDUSTRIAL HEALTH, 44(4) 674-678, Oct, 2006
Survey of food and airborne allergen-specific IgE levels in a general population of 3-year-old Japanese children

Kayoko Takagi, Reiko Teshima, Haruyo Okunuki, Akiko Hachisuka, Jun-Ichi Sawada, Kohichi Kojima, Kazuko Takahashi, Motoyasu Ohsawa, Takahiko Yoshida

Allergology International, 54(4) 581-587, 2005
中国製ダイエット用健康食品中のN-nitrosofenfluramineの光学純度の決定

中台亜里, 稲垣弘文, 南正康, 高橋秀依, 南目梨江, 大沢基保, 池上四郎

YAKUGAKU ZASSHI, 123(9) 805-809, 2003
A simple Bioassay for evaluating immunotoxic properties of chemicals by use of in vitro antibody production system

K Takahashi, M Ohsawa, H Utsumi

JOURNAL OF HEALTH SCIENCE, 48(2) 161-167, Apr, 2002
Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals

F Otsuka, Okugaito, I, M Ohsawa, A Iwamatsu, K Suzuki, S Koizumi

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1492(2-3) 330-340, Jul, 2000
Bacterial lipopolysaccharide acts as an adjuvant to induce autoimmune arthritisin mice

S Yoshino, E Sasatomi, M Ohsawa

IMMUNOLOGY, 99(4) 607-614, Apr, 2000
The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice.

YOSHINO S, OHSAWA M

British Journal of Pharmacology, 129(7) 1309-1314, 2000
Successful induction of adjuvant arthritis in mice by treatment with a monoclonal antibody against IL-4

S Yoshino, Y Murata, M Ohsawa

JOURNAL OF IMMUNOLOGY, 161(12) 6904-6908, Dec, 1998
Diesel exhaust particles block induction of oral tolerance in mice

S Yoshino, M Ohsawa, M Sagai

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 287(2) 679-683, Nov, 1998
Effect of a monoclonal antibody against interleukin-4 on the induction of oral tolerance in mice

S Yoshino, M Ohsawa

EUROPEAN JOURNAL OF PHARMACOLOGY, 336(2-3) 203-209, Oct, 1997
Biomarkers for responses to heavy metals

M Ohsawa

CANCER CAUSES & CONTROL, 8(3) 514-517, May, 1997
Topoisomerase II inhibitors fail to induce chromosome-type aberrations in etoposide-resistant cells: Evidence for essential contribution of the cleavable complex formation to the induction of chromosome-type aberrations

H Suzuki, Y Tarumoto, M Ohsawa

MUTAGENESIS, 12(1) 29-33, Jan, 1997
Immunotoxic effect of low dose cisplatin in mice

Yasuhide Kouchi, Yasuhiro Maeda, Akinobu Ohuchida, Motoyasu Ohsawa

Journal of Toxicological Sciences, 21(4) 227-233, 1996
ORAL TOLERANCE TO OVALBUMIN IN MICE AS A MODEL FOR DETECTING MODULATORS OF THE IMMUNOLOGICAL-TOLERANCE TO A SPECIFIC ANTIGEN

JH KIM, M OHSAWA

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 18(6) 854-858, Jun, 1995
ENHANCING EFFECTS OF DIPHENYL DIMETHYL DICARBOXYLATE ON SERUM ANTIBODY-PRODUCTION IN BALB/C MICE

JH KIM, YK AHN, M OHSAWA

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 18(1) 24-27, Jan, 1995
Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells

SUZUKI H, IKEDA T, YAMAGISHI T, NAKAIKE S, NAKANE S, OHSAWA M

Mutation Research, 328(2) 151-161, 1995
Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein II-A gene

Journal of Biological Chemistry, 23 23700-23707, 1994

More

Misc.

9

A note for preclinical safety evaluation of bioproducts: future challenges

Annual report of Hatano Research Institute., 32 28-32, 2009
食の安全を求めてー化学物質について・食中毒の動向

渡辺卓穂, 大沢基保

臨床と微生物, 35(増刊) 119-125, 2008
環境汚染物質の免疫毒性

組織培養工学, 24(7) 260-263, 1998
Immunotoxicity of environmental chemicals.

The Tissue Culture Engineering, 24(7) 260-263, 1998
中毒研究における免疫毒性

中毒研究, 10 339-344, 1997
Immunotoxicity in clinical toxicology

10 339-344, 1997
化学物質・薬物の免疫毒性とその発現機構

大沢基保

The Journal of Texicological Sciences, 20(4) 87-93, 1995
微量元素代謝の異常と免疫変化

栄養-評価と治療, 10(3) 237-244, 1993
Immune alterations in abnormality of trace element metabolism.

Japanese Journal of Nutritional Assessment, 10(3) 237-244, 1993

Books and Other Publications

17

Bioassay and Bio-informatics -forEnvironmental Assessment and Medical Sciences-

OHSAWA Motoyasu (Role: Contributor, 6.Immune Toxicity: 6.1 Concept, 6.4 In vitro IgM Production Test)

Kougaku-Tosho, Publishers, Ltd., Nov, 2011
病態発現と副作用ー3.免疫異常（医薬品トキシコロジー改訂4版：佐藤哲男他編）

南江堂, 2010 (ISBN: 9784524402595)
環境衛生科学（大沢基保，内海英雄編）

南江堂, 2006 (ISBN: 4524401962)
Environmental Health Criteria 236: Principles and Methods for Assessing Autoimmunity Associated with Exposure to Chemicals

WHO Press, World Health Organization, 2006
Environmental Health Criteria 236: Principles and Methods for Assessing Autoimmunity Associated with Exposure to Chemicals

WHO Press, World Health Organization, 2006
トキシコロジー用語事典（日本トキシコロジー学会編）

（株）じほう, 2003
医薬バイオテクノロジー事典（医薬バイオテクノロジー事典編集委員会編）

広川書店, 2003
免疫毒性(トキシコロジー：日本トキシコロジー学会教育委員会編）

朝倉書店, 2002
免疫毒性(医薬品トキシコロジー:佐藤哲男他編)改訂第2版

南江堂, 2000
健康と疾病(衛生化学・公衆衛生学:早津彦哉,菊川清見,大沢基保編)

南江堂, 1998
Health and Disease (In : Pharmaceutical Science for Health and Environment ; Ed. by Hikoya Hayatsu, Kiyomi Kikugawa and Motoyasu Ohsawa)

Nankodo Co., 1998
免疫毒性(医薬品トキシコロジー:佐藤哲男他編)

南江堂, 1996
栄養薬理からみた栄養素の免疫機能への影響:4 ビタミンと微量元素(栄養免疫学:渡辺明治編)

医歯薬出版, 1996
免疫毒性概論(現代病理学大系補遺1:飯島宗一他編)

中山書店, 1995
ミネラル・微量元素と免疫(ミネラル・微量元素の栄養学:鈴木継美,和田攻編)

第一出版, 1994
Nutritional and Toxicological Implication of Trace Elements in the Immune Response. In : Essential and Toxic Trace Elements in Human Health and Disease : An Update

John Wiley & Sons, Inc., 1993
Nutritional and Toxicological Implication of Trace Elements in the Immune Response. In : Essential and Toxic Trace Elements in Human Health and Disease : An Update

John Wiley & Sons, Inc., 1993

Professional Memberships

16

Works

6

Research Projects

10

環境物質の毒性と生体防御の機構

保健医療分野における基礎研究推進事業, 1996 - 2007
Toxicology of Environmental Substances and Defense Mechanisms

Basic Research Promotion Service for Health and Medical Field, 1995 - 2007
生活環境汚染物質による小児での毒性評価のための免疫指標の開発

厚生労働科学研究費補助金, 2001 - 2004
Immunological Evaluation for Toxic Effect of Environmental Pollutants on Cildren

Health and Labour Sciences Research Grants, 2001 - 2004
環境リスク対策における予見的アプローチとしての免疫影響

科学技術振興調整費による省際基礎研究, 1998 - 2001
Immunological Study for Predictive Evaluation of Environmental Risk

SCF Interministerial Basic Research, 1998 - 2001
重金属の免疫毒性学

科学研究費補助金, 1988 - 1997
Immunotoxicology of Heavy Metals

Grant-in-Aid for Scientific Research, 1988 - 1997
サイトカインバランスの生物学的調節法の開発

保健医療分野における基礎研究推進事業
Development of Biological Modulation Methods of Cytokine Balance

Basic Research Promotion Service for Health and Medical Field