論文

査読有り
2004年

Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes

THROMBOSIS RESEARCH
  • K Oishi
  • ,
  • N Ohkura
  • ,
  • M Kasamatsu
  • ,
  • N Fukushima
  • ,
  • H Shirai
  • ,
  • J Matsuda
  • ,
  • S Horie
  • ,
  • N Ishida

114
2
開始ページ
129
終了ページ
135
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.thromres.2004.05.011
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Diabetes is associated with an excess risk of cardiac events, and the risk for infarction is partly determined by plasminogen activator inhibitor-1 (PAI-1). We found that plasma total and active PAI-1 levels increased in a circadian manner in mice with streptozotocin (STZ)-induced diabetes. Circadian expression of PAI-1 mRNA in the lung, heart, liver, and kidney increased in a tissue-specific manner. Peak to peak comparisons revealed that the mRNA expression levels increased by 1.7, 1.7, 1.2, and 1.6-fold in the heart, lung, liver, and kidney, respectively. In contrast, the circadian expression of the clock gene, mPer2, was preserved in the diabetic mice, suggesting that the altered expression of PAI-1 mRNA did not arise due to impaired circadian clocks. Our results suggest that impairment of the coagulation and fibrinolytic systems induced by diabetes is partly due to impaired circadian PAI-1 fluctuation at the level of mRNA expression. (C) 2004 Elsevier Ltd. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/j.thromres.2004.05.011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223576200008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.thromres.2004.05.011
  • ISSN : 0049-3848
  • Web of Science ID : WOS:000223576200008

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