論文

査読有り
2009年

葉酸代謝関連遺伝子多型に基づくテーラーメイド栄養学 -さかど葉酸プロジェクト-

ビタミン
  • 平岡 真実
  • ,
  • 影山 光代
  • ,
  • 百合本 真弓
  • ,
  • 金胎 芳子
  • ,
  • 矢冨 裕
  • ,
  • 大川 龍之助
  • ,
  • 國枝 寛
  • ,
  • 堀江 修一
  • ,
  • 香川 靖雄

83
5
開始ページ
264
終了ページ
274
記述言語
日本語
掲載種別
DOI
10.20632/vso.83.5-6_264
出版者・発行元
公益社団法人 日本ビタミン学会

Elevated serum total homocysteine (tHcy) levels are associated with increased risk for cardiovascular disease and dementia, which can be influenced by folate status and polymorphisms in folate-metabolizing gene, especially methylenetetrahydrofolate reductase (MTHFR) C677T. This risk was successfully corrected by taking 400μg/d of folate. To prevent these diseases personalized health promotion through folate status was carried out with the genotype announcement in the "Sakado Folate Projects". The folate intake of 400μg/d above the current RDA (240μg/d) was recommended for the subjects with MTHFR TT. Serum folate levels were significantly increased and serum tHcy levels were significantly decreased during 4 months our nutritional intervention, particularly in the subjects with MTHFR TT. The frequency of intake of "green leaf vegetables" which were rich in folate and the fortification foods such as "Sakado folate bread" were increased. This nutritional intervention based on personalized nutrition by genotype announcement was effective on behavioral change in the clients and improvement of nutrition status.

リンク情報
DOI
https://doi.org/10.20632/vso.83.5-6_264
CiNii Articles
http://ci.nii.ac.jp/naid/110007338135
CiNii Books
http://ci.nii.ac.jp/ncid/AN00207833
URL
http://id.ndl.go.jp/bib/10356824
URL
http://search.jamas.or.jp/link/ui/2009260377
ID情報
  • DOI : 10.20632/vso.83.5-6_264
  • ISSN : 0006-386X
  • CiNii Articles ID : 110007338135
  • CiNii Books ID : AN00207833

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