1996年1月
Longitudinal distribution of pulmonary vascular compliance in dogs
JOURNAL OF VETERINARY MEDICAL SCIENCE
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- 巻
- 58
- 号
- 1
- 開始ページ
- 41
- 終了ページ
- 46
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1292/jvms.58.41
- 出版者・発行元
- JAPAN SOC VET SCI
The longitudinal distribution of pulmonary vascular compliance was evaluated in isolated canine lung lobes using arterial(AO), venous-(VO), and double-occlusion (DO) techniques. Total vascular compliance (C-T) was separated into pulmonary arterial (Ca) and venous compliance (C-V) in lumped model of pulmonary circulation. Under constant pulmonary venous pressure (Pv) at 5 mmHg, blood inflow to the lobe (Q) was gradually increased by changing pulmonary arterial pressure (Pa) from 10 to 22 mmHg at 4 mmHg ranges. Changes in vascular blood volume (Delta V) with each increment in Q were determined by decreased reservoir blood volume of perfusion system. DO was performed at each level of Q and allowing all vascular pressures to equilibrate at the same static pressure (Ps), which was equal to the compliance-weighted average pressure in the circulation. C-T was obtained from the slope of the relationship between Pa and Delta V. When Pa and Pv were 14 and 5 mmHg, AO, VO, and DO were performed to measure pressures at Ca (Pea) and Cv (Pcv) and Ps. The arterial-to-venous compliance ratio (Ca/Cv) was evaluated using Pea, Pcv, and Ps measurements. C-T was 0.113 +/- 0.012 ml/kg/mmHg. Ca/Cv was 0.30. Ca and Cv were 0.026 +/- 0.013 and 0.087 +/- 0.007 ml/kg/mmHg, respectively. These data demonstrated the usefulness of AO, VO, and DO techniques in evaluating the longitudinal distribution of compliance in canine pulmonary vasculature.
- リンク情報
- ID情報
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- DOI : 10.1292/jvms.58.41
- ISSN : 0916-7250
- PubMed ID : 8645755
- Web of Science ID : WOS:A1996TT09600007