1999年2月
The effect of prenatal methylmercury exposure on the GSH level and lipid peroxidation in the fetal brain and placenta of mice
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- ,
- ,
- ,
- 巻
- 187
- 号
- 2
- 開始ページ
- 121
- 終了ページ
- 126
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1620/tjem.187.121
- 出版者・発行元
- TOHOKU UNIV MEDICAL PRESS
Effect of prenatal exposure to methylmercury (MeHg) on the glutathione (G-SH) levels and lipid peroxidation in the fetal brain was examined. Pregnant ICR mice mere injected with 3 mgHg/kg of:MeHg on gestational day 12, 13 and 14 (G12-14). On the G14 or G17, the fetal brains were removed and their GSH levels and thiobarbituric acid-reactive substances (TBARS) levels were determined. On the G17, GSH level of MeHg-treated fetal brain was significantly higher than that of the control brain; the TEARS level showed the similar trend but the difference was not significant. These results indicated that the prenatal MeHg treatment disturbed the normal GSH level in the fetal brain and warranted further investigation on the significance of this GSH perturbation.
- リンク情報
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- DOI
- https://doi.org/10.1620/tjem.187.121
- CiNii Articles
- http://ci.nii.ac.jp/naid/10013372661
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10228983
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000079530700004&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1620/tjem.187.121
- ISSN : 0040-8727
- eISSN : 1349-3329
- CiNii Articles ID : 10013372661
- PubMed ID : 10228983
- Web of Science ID : WOS:000079530700004