2007年11月
Expression level of sterol regulatory element-binding proteins in a novel rat model of metabolic syndrome
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
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- 巻
- 34
- 号
- 1
- 開始ページ
- S17
- 終了ページ
- S19
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1111/j.1440-1681.2007.04763.x
- 出版者・発行元
- WILEY-BLACKWELL
1. In the present study, the expression of sterol regulatory element-binding proteins (SREBPs) in livers of a novel rat model of metabolic syndrome, namely SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF), as well as its lean littermates (SHRSP.lean), was examined.
2. The expression of SREBP-1c was significantly elevated in SHRSP.ZF rats, whereas expression of SREBP-2 was significantly decreased.
3. Serum cholesterol levels in SHRSP.ZF rats were significantly higher than those in SHRSP.lean rats.
4. Elevation of cholesterol levels by cholesterol loading significantly elevated SREBP-1c levels and significantly decreased SREBP-2 levels in SHRSP.lean rats, suggesting that serum cholesterol levels may be closely related to the expression SREBPs.
5. These results suggest that the expression of SREBP-1c and -2 is modified in the metabolic syndrome rats as a result of the high cholesterol level in these rats.
2. The expression of SREBP-1c was significantly elevated in SHRSP.ZF rats, whereas expression of SREBP-2 was significantly decreased.
3. Serum cholesterol levels in SHRSP.ZF rats were significantly higher than those in SHRSP.lean rats.
4. Elevation of cholesterol levels by cholesterol loading significantly elevated SREBP-1c levels and significantly decreased SREBP-2 levels in SHRSP.lean rats, suggesting that serum cholesterol levels may be closely related to the expression SREBPs.
5. These results suggest that the expression of SREBP-1c and -2 is modified in the metabolic syndrome rats as a result of the high cholesterol level in these rats.
- リンク情報
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- DOI
- https://doi.org/10.1111/j.1440-1681.2007.04763.x
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002242970122539
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000250780400007&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1111/j.1440-1681.2007.04763.x
- ISSN : 0305-1870
- J-Global ID : 201002242970122539
- Web of Science ID : WOS:000250780400007