1993年7月
STRUCTURE, EXPRESSION AND CHROMOSOMAL LOCALIZATION OF THE GENE ENCODING HUMAN 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE
GENE
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- 巻
- 129
- 号
- 2
- 開始ページ
- 297
- 終了ページ
- 301
- 記述言語
- 英語
- 掲載種別
- 記事・総説・解説・論説等(学術雑誌)
- DOI
- 10.1016/0378-1119(93)90283-9
- 出版者・発行元
- ELSEVIER SCIENCE BV
Four human genomic DNA clones for 2', 3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) were isolated by screening a human genomic library with human CNP cDNA clones as probes. Restriction mapping and sequence analysis revealed that the human CNP gene is about 8.5 kb long and composed of four exons interrupted by three introns. There are two transcription start points and in human brain, two forms of CNP mRNA are produced from a single gene by alternative splicing, similar to mouse. A homology search of the 5'-flanking regions of exon 0 and exon 1 in the human CNP gene indicated the presence of oligodendroglia-specific elements and myelin basic protein transcription element (MBTE) motif, in addition to TATA-box-like sequences. Spot blot hybridization of flow-sorted human chromosomes with the 3'-noncoding region of the human CNP cDNA showed the localization of CNP to chromosome 17.
- リンク情報
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- DOI
- https://doi.org/10.1016/0378-1119(93)90283-9
- CiNii Articles
- http://ci.nii.ac.jp/naid/80007179559
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/8392017
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LP10400020&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/0378-1119(93)90283-9
- ISSN : 0378-1119
- CiNii Articles ID : 80007179559
- PubMed ID : 8392017
- Web of Science ID : WOS:A1993LP10400020