MISC

1995年4月

EFFECT OF T-CELL DEFICIENCY ON THE FORMATION OF PERIAPICAL LESIONS IN MICE - HISTOLOGICAL COMPARISON BETWEEN PERIAPICAL LESION FORMATION IN BALB/C AND BALB/C NU/NU MICE

JOURNAL OF ENDODONTICS
  • N TANIISHII
  • ,
  • K KUCHIBA
  • ,
  • T OSADA
  • ,
  • Y WATANABE
  • ,
  • T UMEMOTO

21
4
開始ページ
195
終了ページ
199
記述言語
英語
掲載種別
出版者・発行元
WILLIAMS & WILKINS

The role of T-cells in the development of periapical lesions was investigated immunohistochemically using 16 normal (BALB/c) mice and 16 nude (BALB/c nu/nu) mice (congenitally T-cell-deficient mice). The pulp chambers of maxillar first molars of all mice were opened, and the infiltrated immunocytes (anti-Thy1.2, -Lyt-1, -Lyt-2, -L3T4, -I-A(d), -IgG, and -IgM positive cells) were determined immunohistochemically at 2, 4, 6, and 8 wk after operation. Periapical lesions appeared at 2 wk in both mouse groups. Numerous anti-I-A(d) positive-stained cells appeared at 2 wk, anti-I-A(d), -Thy1.2 (-Lyt-1, -L3T4), -IgG positive-stained cells appeared between 4 and 8 wk, and periapical lesions with bone resorption rapidly increased until 4 wk in normal mice. On the other hand in nude mice, only anti-I-A(d) and -IgG positive cells were present from 4 to 6 wk, and the progress of periapical lesions with inflammatory cells stopped at 6 wk. Furthermore, numerous fibroblasts were found instead of inflammatory cells at 8 wk. These findings suggest that the progression of periapical lesions with bone resorption required helper T-cells and numerous immunoglobulin-producing cells.

Web of Science ® 被引用回数 : 21

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995QP94500007&DestApp=WOS_CPL

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