Ohtani-Kaneko Ritsuko

J-GLOBAL         Last updated: Jun 20, 2017 at 12:05
Ohtani-Kaneko Ritsuko
Toyo University
Faculty of Life SciencesDepartment of Life Sciences
Job title

Research Areas


Academic & Professional Experience

St.Marianna University School of Medicine, lecturer
St.Marianna University School of Medicine, Assistant Professor
St.Marianna University School of Medicine, Research Assistant
Alberta University , Post doctoral Research Fellow
Yamagata University, Research Assistant


Graduate School, Division of Science, The University of Tokyo
Faculty of Science, The University of Tokyo

Published Papers

Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.
Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R.
Journal of Anatomy   228(5) 792-804   May 2016   [Refereed]
An Easy-to-Use Polystyrene Microchip-based Cell Culture System.
Tazawa H, Sunaoshi S, Tokeshi M, Kitamori T, Ohtani-Kaneko R.
Anal Sci.   32(3) 349-353   Apr 2016   [Refereed]
Mouse pups lacking collapsin response mediator protein 4 manifest impaired olfactory function and hyperactivity in the olfactory bulb.
Tsutiya A, Nishihara M, Goshima Y, Ohtani-Kaneko R.
Eur J Neurosci.   42(6) 2335-2345   Aug 2015   [Refereed]
A microfluidic cell culture system for monitoring of sequential changes in endothelial cells after heat stress.
Tazawa H, Sato K, Tsutiya A, Tokeshi M, Ohtani-Kaneko R.
Thromb Res   136(2) 328-334   2015   [Refereed]
Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells.
Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T.
Biosci Biotechnol Biochem.   July 25 1-9   Jul 2014   [Refereed]
Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice.
T.Iwakura M.Sakoh, A.Tsutiya, N.Yamashita, A.Ohtani, M.Tsuda, S.Ogawa, S.Tsukahara, M.Nishihara, T.Shiga, Y.Goshima, T.Kato, R.Ohtani-Kaneko.
Developmental Neurobiology   73(2) 502-517   Apr 2013   [Refereed]
Postnatal alteration of collapsin response mediator protein 4 mRNA expression in the mouse brain.
A. Tsutiya, R. Ohtani-Kaneko
J. Anatomy   221 341-351   Jul 2012   [Refereed]
17β-estradiol prevents reduction of retinal phosphorylated 14-3-3 zeta protein levels following a neurotoxic insult.
N. Koseki, Y.Kitaoka, Y.Munamasa, K. Kojima, S. Ueno, Ohtani-Kaneko R.
1433 145-152   Jan 2012   [Refereed]
Sexual dimorphism of gonadotropin-releasing hormone type-III (GnRH3) neurons and hormonal sex reversal of male reproductive behavior in Mozambique tilapia
Asami Kuramochi, Atsuhiro Tsutiya, Toyoji Kaneko, Ritsuko Ohtani-Kaneko
28 733-739   Oct 2011   [Refereed]
Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb
Yue Wu, Keiko Moriya-Ito, Takashi Iwakura, Atsuhiro Tsutiya, Masumi Ichikawa, Ritsuko Ohtani-Kaneko
500 77-81   Aug 2011   [Refereed]
Deletion of collapsin response mediator protein 4 results in abnormal layer thickness and elongation of mitral cell apical dendrites in the neonatal olfactory bulb.
Tsutiya A, Watanabe H, Nakano Y, Nishihara M, Goshima Y, Ohtani-Kaneko R.
J Anat.   doi: 10.1111/joa.12434. 1-13   Jan 2016   [Refereed]
Proteomic surveillance of autoantigens in patients with Behcet’s disease by a proteomic approach.
Ooka S., Nakano H., Matsuda T., Okamoto K, Suematsu N, Kurokawa S.,, Masuko K. Ozaki S., Kato T.
Microbiology & Immunology   54 354-361   Jul 2010   [Refereed]
In vitro effects of bisphenol A on developing hypothalamic neurons.
Iwakura T., Iwafuchi M., Muraoka D., Yokosuka M., Shiga T., Watanabe ch., Ohrnai-Kaneko R.
Toxicology   272(41642) 52-58   Jun 2010   [Refereed]
Effects of estrogen on synapsin I distribution in developing hypothalamic neurons.
Ohtani-Kaneko R., Iwafuchi, M. Iwakura1 T., Muraoka D., Yokosuka M.、Shiga T., Watanabe C. 
Neurosci. Res.   66 180-188   Feb 2010
Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells. 
Ohtani-Kaneko R, Tazawa H, Yokosuka M, Yoshida M, Satoh M, Watanabe C.
Toxicology   253(41642) 110-116   Apr 2008   [Refereed]
Involvement of post-translational modification of neuronal plasticity-related proteins in hyperalgesia revealed by a proteomic analysis. Proteomics
Fujisawa H, Ohtani-Kaneko R, Naiki M, Okada T, Masuko K, Yudoh K, Suematsu N, Okamoto K, Nishioka K, Kato T.
Proteomics.   8(8) 1706-1719   Apr 2008   [Refereed]
Effects of unoprostone on phosphorylated extracellular signal-regulated kinase expression in endothelin-1-induced retinal and optic nerve damage.
Munemasa Y, Kitaoka Y, Hayashi Y, Takeda H, Fujino H, Hirata K, Ueno S.(St.Marianna University School of Medicine)
Vis Neurosci.   25(2) 197-208   Mar 2008   [Refereed]
Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias.
Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y, Watanabe C.
Toxicolgy In Vitro.   22 1-9   Jan 2008   [Refereed]
Neuroprotective effect of 17β-estradiol against NMDA-induced retinal neurotoxicity via p-ERK induction
Hayashi Y, Kitaoka Y, Munemasa Y, Ohtani-Kaneko R, Kikusui T, Uematsu A, Takeda H, Hirata K, Mori Y, Ueno S.
Journal of Neuroscience Research   85 386-494   Jan 2007   [Refereed]
Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development.
Kato T, Ohtani-Kaneko R, Shiga T.
Neurosci Research.   58 402-405   Jan 2007   [Refereed]
Pro-apoptotic role of c-Jun in NMDA-induced neurotoxicity in the rat retina.
Munemasa Y, Ohtani-Kaneko R, Kitaoka Y, Kumai T, Kitaoka Y, Hayashi Y, Watanabe M, Takeda H, Hirata K, Ueno S.
J Neurosci Res   83 907-918   Apr 2006   [Refereed]
Mechanisms underlying estrogen-induced sexual differentiation in the hypothalamus.
Ritsuko Ohtani-Kaneko
Histol Histopathol   21 317-324   Mar 2006   [Refereed]
Liver-type Fatty Acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction.
Kamijo-Ikemori A, Sugaya T, Obama A, Hiroi J, Miura H, Watanabe M, Kumai T, Ohtani-Kaneko R, Hirata K, Kimura K.
American Journal of Pathology   169 1107-1117   Jan 2006   [Refereed]
Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis.
Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K.
Eur. J. Endocrinol   153 1-11   Oct 2005   [Refereed]
Chloride turnover and ion-transporting activities of yolk-sac preparations (yolk balls) separated from Mozambique tilapia embryos and incubated in freshwater and seawater. 
Hiroi J, Miyazaki H, Katoh F, Ohtani-Kaneko R, Kaneko T.
J Exp Biol   208 3851-3858   Oct 2005   [Refereed]
Functional classification of mitochondrion-rich cells in euryhaline Mozambique tilapia (Oreochromis mossambicus) embryos, by means of triple immunofluorescence staining for Na+/K+-ATPase, Na+/K+/2Cl- cotransporter and CFTR anion channel.
Hiroi J, McCormick SD, Ohtani-Kaneko R, Kaneko T.
J. Exp. Biol   208 2023-2036   Jun 2005   [Refereed]
Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat.
Munemasa Y, Ohtani-Kaneko R, Kitaoka Y, Kuribayashi K, Isenoumi K, Kogo J, Yamashita K, Kumai T, Kobayashi S, Hirata K, Ueno S.
Brain Res   1044 227-240   Apr 2005   [Refereed]
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T.
Cancer Res   65 6-10   Jan 2005   [Refereed]
Developmental Regulation of Activated ERK Expression in the Spinal Cord and Dorsal Root Ganglion of the Chick Embryo.
Kato T, Ohtani-Kaneko R, Ono K, Okado N, Shiga T.
Neurosci. Res   52 11-19   Jan 2005   [Refereed]
Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules
Kamijo-Ikemori A, Sugaya T, Obama A, Hiroi J, Miura H, Watanabe M, Kumai T, Ohtani-Kaneko R, Hirata K, Kimura K.
American Journal of Pathology   165(1243-1255) 1243-1255   Oct 2004   [Refereed]
Structure and developmental expression of hatching enzyme genes of the Japanese eel Anguilla japonica : an aspect ofthe evolution of fish hatching enzyme gene.
Hiroi J, Maruyama K, Kawazu K, Kaneko T, Ohtani-Kaneko R, Yasumasu S.
Development genes and evolution   214(176-184) 176-184   Mar 2004   [Refereed]
Circadian rhythm of melatonin release from the photoreceptive pineal organ of a teleost, Ayu (plecoglossus altivelis )in flow.. Thorough culture.
Iigo M, Fujimoto Y, Gunji-Suzuki M, Yokosuka M, Hara M, Ohtani-Kaneko R, Tabata M, Aida K, Hirata K.
Journal of Neuroendocrinology   16 45-51   Jan 2004   [Refereed]
Low-dose perinatal diethylstilbestrol exposure affected behaviors and hypothalamic estrogen receptor-a-positive cell in the mouse.
Tanaka M, Ohtani-Kaneko R, Yokosuka M, Watanabe C.
Neurotoxicology and Teratology   26(261-269)    2004   [Refereed]
Gene expression study of thyrotopin releasing hormone (TRH) receptor using RT-PCR: Relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas
Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K.
Endocrine Journal   50(459-467)    2003   [Refereed]
Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats.
Hara M, Yoshida M, Nishijima H, Yokosuka M, Iigo M, Ohtani-Kaneko R, Shimada A, Hasegawa T, Akama Y, Hirata K.
Journal of Pineal Research   30 129-138   Apr 2001   [Refereed]
Accumulation of phosphorylated neurofilaments and increase in apoptotic specific protein (ASP) and phosphorylated c-Jun induced by proteasome inhibitors.
Masaki R, Saito T, Yamada K, Ohtani-Kaneko R.
Journal of Neuroscience Research   62(1) 75-83   Oct 2000   [Refereed]
Developmental changes in the localization of activated C-jun N-terminal kinase (JNK/SAPK) in the chick spinal cord.
Ohtani-Kaneko R, Shiga T, Yamashita K, Masaki R, Hirata K.
Journal of Comparative Neurology   426 622-631   2000   [Refereed]
Proteins recognized by antibodies against isolated cytological heterochromatin from rat liver cells change their localization between cell species and between stages of mitosis (interphase vs metaphase).
Hara M, Igarashi J, Yamashita K, Iigo M, Yokosuka M, Hirata K, Herbert CD.
Tissue & Cell   31(5) 505-513   1999   [Refereed]
Female-soiled bedding induced Fos immunoreactivity in the ventral part of the premammillary nucleus (PMv) of the male mouse.
Yokosuka M, Matsuoka M, Ohtani-Kaneko R, Iigo M, Hara M, Hirata K, Ichikawa M.
Physiology & Behavior   68(41641) 257-261   Dec 1999   [Refereed]
Ohtani-Kaneko R, Takada K, Iigo M, Hara M, Yokosawa H, Kawashima S, Ohkawa K, Hirata K.
Neurochemical Research   23(11) 1435-1443   Nov 1998   [Refereed]
Regulation by light and darkness of melatonin secretion from the superfused masu salmon (Oncorhynehus masou) pineal organ
Iigo M, Kitamura S, Ikuta K, Sanchez-Vazquez FJ, Ohtani-Kaneko R, Hara M, Suzuki T, Tabata M, Aida K.
Biological Rhythm Research   29(1) 86-97   1998   [Refereed]
Effects of low-protein diet on prolactin-and growth hormone-producing cells in the rat pituitary gland.
Hara M, Herbert DC, Taniguchi T, Hattori A, Ohtani-Kaneko R, Iigo M, Kato Y, Hirata K.
The Anatomical Record   251 37-43   1998   [Refereed]
Photic and circadian regulations of melatonin rhythms in fishes.
Iigo M, Hara M, Ohtani-Kaneko R, Hirata K, Tabata M, Aida K.
Biological Signals   6(225) 232-232   Jul 1997   [Refereed]
Characterization, Guanosine 5'-O-(3-thiotriphosphate) modulation, daily variation, and localization of melatonin-binding sites in the catfish (Silurus a sotus) Brain (共著)
Iigo M, Hattori A, Ohtani-Kaneko R., Aida K
General and Comparative Endocrinology   108 45-55   1997   [Refereed]
Administration of melatonin and related indoles prevents exercise-induced cellular oxidative changes in rats.
Hara M, Iigo M, Ohtani-Kaneko R, Nakamura N, Suzuki T, Reiter RJ, Hirata K.
Biological Signals   6(2) 90-100   Mar 1997   [Refereed]
Melatonin binding sites in the Goldfish Retina.
Iigo M, Ohtani-Kaneko R, Hara M, Hirata K, Aida K.
Zoological Science   14 601-607   Apr 1997   [Refereed]
Regulation by guanine nucleotides and cations of melatonin binding sites in the goldfish brain.
Iigo M, Ohtani-Kaneko R, Hara M, Hattori A, Takahashi H, Tabata M, Suzuki T, Aida K.
Biological Signals   6(1) 29-39   Jan 1997   [Refereed]
Ocular melatonin rhythms in the Goldfish, Carassius auratus.
Iigo M, Sánchez-Vázquez FJ, Hara M, Ohtani-Kaneko R, Hirata K, Shinohara H, Tabata M, Aida K.
Journal of Biological Phythms   12(1) 182-192   Oct 1997   [Refereed]
Ohtani-Kaneko R, Asahara M, Takada K, Kanda T, Iigo M, Hara M, Yokosawa H, Ohkawa K, Hirata K.
Neuroscience Research   26(4) 349-355   Dec 1996   [Refereed]
Iigo M, Furukawa K, Hattori A, Hara M, Ohtani-Kaneko R, Suzuki T, Tabata M, Aida K.
Neurosclence Letters   197(1) 61-64   Sep 1995   [Refereed]
Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates
Hattori A, Migitaka H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kaneko R, Hara M, Suzuki T, Reiter RJ.
Biochemistry and molecular biology international   35(3) 627-634   Mar 1995   [Refereed]
Iigo M, Kobayashi M, Ohtani-Kaneko R, Hara M, Hattori A, Suzuki T, Aida K.
Brain Research   644(2) 213-220   May 1994   [Refereed]
Effects of testosterone and luteinizing hormone- releasing hormone on occurrence of ubiquitin in the nucleus of rat LH cells in vitro.
Ohtani-Kaneko R, Wada Y, Hattori A, Takada K, Hara M, Iigo M, Imai K, Suzuki T.
Endocrine Journal   2(1) 69-73   1994   [Refereed]
Location of forelimb motoneurons in the Japanese and toad (Bufo japonicus); A horseradish peroxidase study.
Oka Y, Ohtani R, Satou M, Ueda K.
Journal of Comparative Neurology   286 376-383   1989   [Refereed]
Localization of calcitonin gene-related peptide in the small intestine of various vertebrate species.
Ohtani R, Kaneko T, Kline LW, Labedz T, Tang Y, Pang PK.
Cell and Tissue Research   258(1) 35-42   Oct 1989   [Refereed]
A novel cell type in the parathyroid glands of spontaneously hypertensive rats.
Kaneko T, Ohtani R, Lewanczuk RZ, Pang KTP.
Americal Journal of Hypertension   2(7) 549-552   Jul 1989   [Refereed]
The development of corticospinal tract (CST) neurons.
R.Ohtani, T Shirai
Proceeding of 6th Meeting of Singer Symposium.   6 473-483   Oct 1988   [Refereed][Invited]
Sexually dimorphic muscle in the forelimb muscle of Japanese toad, Bufo japonicus.
Oka Y, Ohtani R, Satou M, Ueda K.
Journal of Morphology   180 297-308   1985   [Refereed]
Reduction of lipofuscin by centrophenoxine and chlorpromazine in the neurons of rat cerebral hemisphere in primary culture.
Ohtani R, Kawashima S.
Experimental Gerontology   18 105-112   Apr 1983   [Refereed]


A rotary slicer for brain research
R.Ohtani, H. Kato
J Yamagata School of Med      1986   [Refereed]
The effects of estradiol 17β on the nerite elongation
R. Ohtani, S. Kawashima
Annotationes Zoological Japoneses   56    1983   [Refereed]

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2007 - 2008
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2007
It has become increasingly clear that estrogens, one of steroids hormones, play an important role in learning and memory across the lifespan. Estrogens also play critical roles in the sexual differentiation of the developing rat hypothalamus to fo...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C), 基盤研究(C))
Project Year: 1995 - 1996    Investigator(s): Ritsuko OHTANI
Changes in ubiquitin-immunoreactivity after nerve growth factor (NGF) treatment were investigated in PC12h cells. Ubiquitin-immunoreactivity was increased in the nucleus of NGF-treated cells. The quantitiy analysis revealed that, after 7days of NG...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1991 - 1992    Investigator(s): Ritsuko KANEKO
Collateral elimination (CE) has been known to occur in corticospinal tract (CST) neurons during the postnatal development in rodents. However. how collterals eliminate remains unclear. Although some proteolytic processes might be involved in CE, f...