Mikihiro Tsutsumi - My portal

Profile Information

Affiliation: Professor, School of Medicine, Kanazawa Medical University

Degree: Ph.D in Medicine

J-GLOBAL ID: 200901084231249289
researchmap Member ID: 1000098021

Research Interests

Education

Faculty of Medicine, Kanazawa Medical University

Committee Memberships

Awards

1996

Chager in laminin content in liver of patients with alcoholic liver disease
1994

Genetic Polymorphisms of Cytochrome P4502E1 Related to the Development of Alcoholic Liver Disease

Papers

110

Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats

28: 143 s10020-022-00566-6, Nov, 2022 Peer-reviewed
Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis

Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George

British Journal of Pharmacology, 177(22) 5195-5207, Nov, 2020 Peer-reviewed
Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Journal of Molecular Medicine, 98(9) 1203-1213, Sep, 2020 Peer-reviewed
Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats

Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro

European Journal of Pharmacology, 863 172681, Dec, 2019 Peer-reviewed
The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Turkish Journal ofMedical Scences, 49 1350-1357, Oct, 2019 Peer-reviewed
Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi

Cell Death & Disease, 10 18, Jan, 2019 Peer-reviewed
Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis

Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima

Scientific Reports, 9 708, Jan, 2019 Peer-reviewed
Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD

Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi

The journal of Japan Mibyo System Association, 24(1) 19-25, Mar, 2018 Peer-reviewed
MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice

Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(12) 3821-3835, Dec, 2017 Peer-reviewed
An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma

Nobuyuki Toshikuni, Yasuhiro Matsue, Kazuaki Ozaki, Kaho Yamada, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi

RADIOLOGY AND ONCOLOGY, 51(3) 263-269, Sep, 2017 Peer-reviewed
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD

Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi

NUTRIENTS, 9(6) 634, Jun, 2017 Peer-reviewed
Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis

Nobuyuki Toshikuni, Mutsumi Tsuchishima, Atsushi Fukumura, Tomiyasu Arisawa, Mikihiro Tsutsumi

GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017 9127847, 2017 Peer-reviewed
Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease.

Shigeo Sueyoshi, Setsu Sawai, Mamoru Satoh, Masanori Seimiya, Kazuyuki Sogawa, Atsushi Fukumura, Mikihiro Tsutsumi, Fumio Nomura

World journal of hepatology, 8(36) 1610-1616, Dec 28, 2016 Peer-reviewed
GGsTop, a novel and specific gamma-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats

Kaneto Tamura, Nobuhiko Hayashi, Joseph George, Nobuyuki Toshikuni, Tomiyasu Arisawa, Jun Hiratake, Mutsumi Tsuchishima, Mikihiro Tsutsumi

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 311(2) G305-G312, Aug, 2016 Peer-reviewed
Management of gastroesophageal varices in cirrhotic patients: current status and future directions

Nobuyuki Toshikuni, Yoshitaka Takuma, Mikihiro Tsutsumi

ANNALS OF HEPATOLOGY, 15(3) 314-325, May, 2016 Peer-reviewed
Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations

Natsuko Kawada, Hiroyuki Uehara, Shigenori Nagata, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Yasuhiko Tomita

PANCREATOLOGY, 16(3) 441-448, May, 2016
Association between transforming growth factor-beta 1-509 C > T variants and hepatocellular carcinoma susceptibility: a meta-analysis

N. Toshikuni, Y. Matsue, T. Minato, N. Hayashi, M. Tsutsumi

NEOPLASMA, 63(6) 961-966, 2016 Peer-reviewed
Serum endocan as a survival predictor for patients with liver cirrhosis

Nobuyuki Toshikuni, Kazuaki Ozaki, Joseph George, Mikihiro Tsutsumi

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29(8) 427-430, Nov, 2015
Serum endocan as a survival predictor for patients with liver cirrhosis

Nobuyuki Toshikuni, Kazuaki Ozaki, Joseph George, Mikihiro Tsutsumi

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29(8) 427-430, Nov, 2015
Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma

Natsuko Kawada, Hiroyuki Uehara, Shigenori Nagata, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Yasuhiko Tomita

PANCREATOLOGY, 15(6) 654-660, Nov, 2015

Misc.

Clinical significance of hepatitis GB virus C infection in alcoholic liver disease

M Tsutsumi, M Sawada, S Takase, WB Chen, Y Ueshima, M Tsuchishima, K Shimanaka, T Itoh, H Kawahara

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 21(9) 1722-1725, Dec, 1997
Characteristics of serum hyaluronate concentrations in patients with alcoholic liver disease

M Tsutsumi, S Urashima, S Takase, Y Ueshima, T Tsuchishima, K Shimanaka, H Kawahara

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 21(9) 1716-1721, Dec, 1997
Serum markers for hepatic fibrosis in alcoholic liver disease: Which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?

M Tsutsumi, S Takase, S Urashima, Y Ueshima, H Kawahara, A Takada

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 20(9) 1512-1517, Dec, 1996
Relative risk for the development of hepatocellular carcinoma in alcoholic patients with cirrhosis: A multiple logistic-regression coefficient analysis

M Tsutsumi, M Ishizaki, A Takada

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 20(4) 758-762, Jun, 1996
Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: A new candidate for early diagnosis of hepatocellular carcinoma

M Tsutsumi, D Sakamuro, A Takada, SC Zang, T Furukawa, N Taniguchi

HEPATOLOGY, 23(5) 1093-1097, May, 1996
GENETIC POLYMORPHISMS OF CYTOCHROME P4502E1 RELATED TO THE DEVELOPMENT OF ALCOHOLIC LIVER-DISEASE

M TSUTSUMI, A TAKADA, JS WANG

GASTROENTEROLOGY, 107(5) 1430-1435, Nov, 1994
DETECTION OF ANTIGENS RELATED TO HEPATITIS-C VIRUS-RNA ENCODING THE NS5 REGION IN THE LIVERS OF PATIENTS WITH CHRONIC TYPE-C HEPATITIS

M TSUTSUMI, S URASHIMA, A TAKADA, T DATE, Y TANAKA

HEPATOLOGY, 19(2) 265-272, Feb, 1994
ROLE OF ETHANOL-INDUCIBLE CYTOCHROME-P-450 2E1 IN THE DEVELOPMENT OF HEPATOCELLULAR-CARCINOMA BY THE CHEMICAL CARCINOGEN, N-NITROSODIMETHYLAMINE

M TSUTSUMI, Y MATSUDA, A TAKADA

HEPATOLOGY, 18(6) 1483-1489, Dec, 1993
IN-VIVO INDUCTION OF HEPATIC P4502E1 BY ETHANOL - ROLE OF INCREASED ENZYME-SYNTHESIS

M TSUTSUMI, JM LASKER, T TAKAHASHI, CS LIEBER

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 304(1) 209-218, Jul, 1993
CHANGES IN TYPE-IV COLLAGEN CONTENT IN LIVERS OF PATIENTS WITH ALCOHOLIC LIVER-DISEASE

M TSUTSUMI, S URASHIMA, Y MATSUDA, S TAKASE, A TAKADA

HEPATOLOGY, 17(5) 820-827, May, 1993
CHARACTERISTIC FEATURES OF ALCOHOLIC LIVER-DISEASE IN JAPAN - A REVIEW

A TAKADA, S TAKASE, M TSUTSUMI

GASTROENTEROLOGIA JAPONICA, 28(1) 137-148, Feb, 1993
Effects of azidothymidine on type C hepatitis

International Hepatology Communications, 1,209-214, 1993
THE ALCOHOL-ALTERED LIVER MEMBRANE ANTIBODY AND HEPATITIS-C VIRUS-INFECTION IN THE PROGRESSION OF ALCOHOLIC LIVER-DISEASE

S TAKASE, M TSUTSUMI, H KAWAHARA, N TAKADA, A TAKADA

HEPATOLOGY, 17(1) 9-13, Jan, 1993
Immunohistochemical localization of ethanol-inducible P450 II E1 in the Rat alimentary tract.

Gastroenterology, 99(4), 1990
Interaction of ethanol with enflurane metabolism and toxicity : Role of P450 II E1

Alcoholism : clinical and Experimental Research, 14(2), 1990
The intralobular distribution of ethanol-inducible P450 II E1 in Rat and human liver.

Hepatology, 10(4), 1989
Effects of ethanol and its metabolites on collagen synthesis by cultured Rat liver cells.

Journal of Gastroenterology and Hepatology., 4(3), 1989
Hepatic aldehyde dehydrogenase activity in liver disease, with particular emphasis on alcoholic liver disease

Hepatology, 9(5), 1989
Subcellular localization of aldehyde dehydrogenase isozymes in human liver.

Gastroenterologia Japonica, 24(1), 1989
Connective tissue components in cultured parenchymal cells of rat liver : Immunohistochemical studies.

Laboratory Investigation, 58(1), 1988

Books and Other Publications

アルコール性肝障害の診断基準と重症度

Jan, 2018
アルコール性肝障害の実態と発生機序

Dec, 2015
再生医療にむけて

Jul, 2015
アルコール性肝疾患の進展と改善

May, 2014
アルコール性肝障害の病態

May, 2014
4.1.6.3下部消化管

Apr, 2013
8 アルコール性肝障害

Feb, 2013
【アルコール性肝障害編】Ⅲ．治療編 C薬物療法＋減酒薬

Jan, 2013
アルコール性肝障害

2011
アルコール依存と生活習慣病

2011
病態生理と動物モデルアルコール性肝障害第3章アルコール性肝障害の病理・病態生理

2010

Presentations

219

高血糖とアルコール大量摂取は肝臓でのアルドース還元酵素発現の誘導を介してGA-AGEsの蓄積を促進する

橋爪智恵子、福村敦、齋藤隆、尾﨑一晶、竹内正義、堤幹宏、土島睦

第58回日本肝臓学会総会, Jun 2, 2022
SUPPRESSION OF OXIDATIVE STRESS INHIBITED OSTEOPONTIN EXPRESSION AND PREVENTED EXPRIMENTALLY INDUCED LIVER INJURY IN RATS

Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima

Nov 12, 2021
非アルコール性脂肪性肝疾患の肝線維化進展度と動脈硬化進行度の関連性

利國信行, 堤幹宏, 土島睦

日本消化器関連学会週間 (JDDW2021), Nov 5, 2021
硬変肝に対するヒト脂肪組織由来幹細胞シート貼付後の動態とその有用性の検討

橋爪智恵子, 堤幹宏, 土島睦

日本消化器関連学会週間 (JDDW2021), Nov 5, 2021
飲酒者における肝脂肪化および肝線維化と粥状動脈硬化の関連性

利國信行, 土島睦, 堤幹宏

第57回日本肝臓学会総会, Jun 18, 2021
アルコール性および非アルコール性脂肪肝に及ぼす終末糖化産物（AGEs）の影響

福村敦, 竹内正義, 齊藤隆, 林伸彦, 津村崇, 楠野颯樹, 山形光慶, 野村匡晃, 久保田龍一, 平川祐希, 松江泰弘, 湊貴浩, 尾﨑一晶, 利國信行, 堤幹宏, 土島睦

第57回日本肝臓学会総会, Jun 18, 2021
アルコール性及び非アルコール性脂肪肝に及ぼす終末糖化産物（AGEs)の影響

福村敦、竹内正義、齊藤隆、林伸彦、津村崇、楠野颯樹、山形光慶、野村匡晃、久保田龍一、平川祐希、松江泰弘、湊貴浩、尾﨑一晶、利國信行、堤幹宏、土島睦

第57回日本肝臓学会総会, Jun 17, 2021
The use of contrast-enhanced ultrasonography and fusion imaging improve the treatment process of radiofrequency ablation for hepatocellular carcinoma

Nobuyuki Toshikuni, Ryuichi Kubota, Yasuhiro Matsue, Kazuaki Ozaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi

May 21, 2021
境界領域の飲酒量が肝障害に及ぼす影響

福村敦, 齊藤隆, 林伸彦, 津村崇, 楠野颯樹, 山形光慶, 野村匡晃, 久保田龍一, 平川祐希, 松江泰弘, 湊貴浩, 尾﨑一晶, 利國信行, 堤幹宏, 土島睦

第107回日本消化器病学会総会, Apr 16, 2021
境界領域の飲酒量が肝障害に及ぼす影響

福村敦, 林伸彦, 久保田龍一, 尾﨑一晶, 堤幹宏, 土島睦

第40回アルコール医学生物学研究会学術集会, Jan 30, 2021
アルコール性肝障害とNAFLDの判別における血清%CDT値の有用性

福村敦、堤幹宏、土島睦

第40回アルコール医学生物学研究会学術集会, Jan 30, 2021
臨床から見たアルコール性臓器障害における現状と課題

堤幹宏

第40回アルコール医学生物学研究会学術集会, Jan 29, 2021
肝疾患における診断用バイオマーカーアルコール性肝障害とNAFLDの判別における血清%CDT値の有効性

福村敦, 堤幹宏, 土島睦

第４０回アルコール医学生物学会, Jan 29, 2021
The utility of image fusion system-guided radiofrequency ablation for hepatocellular carcinoma: a meta-analysis

Toshikuni Nobuyuki, Matsue Yasuhiro, Ozaki Kazuaki, Kubota Ryuichi, Tsuchishima Mutsumi, Tsutsumi Mikihiro

Dec 1, 2020
血清%CDT（糖査欠損トランスフェリン）値がcut off値以下のアルコール性肝障害患者の特徴

福村敦, 齊藤隆, 林伸彦, 湊貴浩, 平川祐希, 久保田龍一, 野村匡晃, 山形光慶, 尾﨑一晶, 堤幹宏, 土島睦

第24回日本肝臓学会大会, Nov 5, 2020
臨床パラメータを活用したアルコール性肝障害の線維化マーカー

利國信行, 土島睦, 堤幹宏

第56回肝臓学会総会, Aug 28, 2020
Inhibition of g-glutamyl transpeptidase ameliorates hepatic ischemia/reperfusion injury in rats with fatty liiver.

Ryuichi Kubota, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George.

The Digital International Liver Congress (EASL-ILC 2020), Aug 27, 2020
Recombinant thrombomodulinprevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats.

Joseph George,Yuki Hirakawa, Atsushi Fukumura, Mutsumi Tsuchishima, Mikihiro Tsutsumi.

The Digestive Disease Week (DDW 2020), May 2, 2020
Serum miRNA-320 as a potent diagnostic biomarker for human hepatocellular carcinoma irrespective of etiology

Joseph George, Takashi Saito, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi.

The 29th Annual Convention of the Asian Pacific Association for the Study of the Liver, Mar 5, 2020
アルコール性脂肪肝炎および非アルコール性脂肪肝炎と高血圧症、2型糖尿病、脂質異常症との関連性

久保田龍一, 利國信行, 福村敦, 林伸彦, 堤幹宏, 土島睦

第39回アルコール医学生物学研究会学術集会, Jan 24, 2020

Professional Memberships

Research Projects

わが国における飲酒の実態把握およびアルコールに関連する生活習慣病とその対策に関する総合的研究

2011 - 2012
急性期入院医療試行診断群分類と活用した調査研究

2002 - 2002
消化管化学発癌に及ぼす長期ｱﾙｺｰﾙ投与の影響

1998 - 1999
Cytochrome P4502E1の遺伝子解析の臨床的有意義

1993 - 1994
C型肝炎の肝細胞障害発現におけるapoptosisの意義

1993 - 1993
化学発癌に対するｃｙｔｏｃｈｒｏｍe P450ⅡE1の意義（肝癌を中心に）

1990 - 1991
培養ラット伊東細胞の機能と分化について

1986 - 1986
肝アルデヒド脱水素酵素Ｓｏｚｙｍｅの細胞内局在についての研究

1984 - 1984