OKIMURA Keiko

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Name
OKIMURA Keiko
Affiliation
Hokuriku University
Section
Faculty of Pharmaceutical Sciences
Job title
Assistant instructor
Degree
Master of Pharmacy(Hokuriku University), Doctor of Philosophy in Pharmaceutical Sciences(Kanazawa University)

Research Areas

 
 

Education

 
 
 - 
1986
Graduate School, Division of Pharmaceutical Sciences, Hokuriku University
 
 
 - 
2008
Division of Life Sciences, Graduate School, Division of National Science and Technology, Kanazawa University
 
 
 - 
1984
Faculty of Pharmaceutical Science, Hokuriku University
 

Published Papers

 
Keiko Okimura*, Junya Yamada , Etsuko Miyamoto
Japanese Journal of Pharmaceutical Health Care and Sciences   43(5) 267-272   May 2017   [Refereed]

Misc

 
Investigation of Structure-Activity Relationships of Derivatives of the Antimicrobial Peptide Lacrain
Keiko Okimura, Keiko Matsubara, Yumi Iha, Yui Shimada
Peptide Science 2018, S. Futaki and K. Matsuzaki (Ed.), The Japanese Peptide Society   22-22   2019   [Refereed]
Development of Polymyxin B3 Analogs with Hydroxy Amino Acids Substituting for its Diaminobutyric Acid Residues.
Yuki Sato, Naoki Sakura, Tatsuo Takahashi, Keiko Okimura, Masakazu Miura, Keiichi Hatakeyama, Keiichi Ohshima and Tohru Mochizuki
Peptide Science 2018, S. Futaki and K. Matsuzaki (Ed.), The Japanese Peptide Society,   26-26   2019   [Refereed]
Naoko Katsuma, Yuki Sato, Kazuhiro Ohki, Keiko Okimura, Kuniharu Ohnishi, and Naoki Sakura
Chem. Pharm. Bull   57(4) 332-336   2009
Kazushi Kanazawa, Yuki Sato, Kazuhiro Ohki, Keiko Okimura, Yoshiki Uchida, Mitsuno Shindo, and Naoki Sakura
Chem. Pharm. Bull   57(3) 240-244   2009
Chem. Pharm. Bull
Antimicrobial Activity of Various Aminocyclohexylcarbonyl-polymyxin B (2-10) Derivatives
Keiko Okimura, Yuki Sato, Kazuhiro Ohki, Kuniharu Ohnishi, and Naoki Sakura
Peptide Science 2008   243-244   2009
Des-fatty acyl-polymyxin B decapeptide analogs with antimicrobial activity specifically against Pseudomonas aeruginosa
Yuki Sato, Naoko Katsuma, Kazuhiro Ohki, Keiko Okimura, Yoshiki Uchida, Kuniharu Ohnishi and Naoki Sakura
Peptide Science 2007   307-308   2008
Keiko Okimura, Kazuhiro Ohki, Yuki Sato, Kuniharu Ohnishi, and Naoki Sakura
Chem. Pharm. Bull   55(12) 1724-1730   2007
Keiko Okimura, Kazuhiro Ohki, Yuki Sato, Kuniharu Ohnishi, Yoshiki Uchida, and Naoki Sakura
Bull. Chem. Soc. Jpn.   80(3) 543-552   2007
Semi-Synthesis of Polymyxin B-(2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of 2,4-Diaminobutyric Acid Residues
Keiko Okimura, Kazuhiro Ohki, Yuki Sato, Kuniharu Ohnishi, and Naoki Sakura
Peptide Science 2006   190   2006
Junko Kobayashi, Kazuhiro Ohki, Keiko Okimura, Tadashi Hashimoto, and Naoki Sakura
Chem. Pharm. Bull.   54(6) 827-831   2006
Isolation and Structure Determination of [Ile7]- and [Ser2]-Polymyxin B1
Kazuhiro Ohki, Keiko Okimura, Kuniharu Ohnishi, and Naoki Sakura
Peptide Science 2005   187-188   2006
Antimicrobial Activity of Des-Fatty Acyl-Polymyxin B Decapeptide N-Terminal Analogs
Naoko Katsuma, Yuki Sato, Kazuhiro Ohki, Keiko Okimura, Yoshiki Uchida, Mitsuno Shindo and Naoki Sakura
Peptide Science 2004   549-550   2005
Naoki Sakura, Tatsuya Itoh, Yoshiki Uchida, Kazuhiro Ohki, Keiko Okimura, Kenzo Chiba, Yuki Sato and Hiroyuki Sawanishi
Bull. Chem. Soc Jpn.   77(10) 1915-1924   2004
Antimicrobial Activity of Polymyxin B3 Analogs Modified at the Hydrophobic Amino Acids
Kazushi Kanazawa, Kazuhiro Ohki, Keiko Okimura, Yuki Sato, Yoshiki Uchida and Naoki Sakura
Peptide Science 2003   255-256   2004
Keiko Okimura, Kazuhiro Ohki, Sotoo Nagai and Naoki Sakura
Biol. Pharm. Bull.   26(8) 1166-1169   2003
Chemical Conversion of Natural Polymyxin B to Polymyxin B Nonapeptide Derivatives
Keiko Okimura, Kazuhiro Ohki, Sotoo Nagai, Yoshiki Uchida and Naoki Sakura
Peptide Science 2002   161-162   2003
Synthesis and Antimicrobial Activity of Polymyxin B Component Peptides
Kazuhiro Ohki, Hiroyuki Sawanishi, Sotoo Nagai, Keiko Okimura, Yoshiki Uchida and Naoki Sakura
Peptide Science 2001   189-192   2002
HPLC Analysis of Fatty Acylglycine in the Hydrolysates of N-Terminally Blocked Peptides by Fatty Acids
Keiko Okimura, Kazuhiro Ohki, Sotoo Nagai and Naoki Sakura
Peptide Science 2000   413-416   2001
Keiko Okimura, Kaori Sugimoto, Kazuhiro Ohki, Naoki Sakura and Tadashi Hashimoto
Chemical & Pharmaceutical Bulletin   47(9) 1249-1255   1999
Regioselective cleavage of N-terminal myristoyl-peptide and the identification of the blocking group
Keiko Okimura, Kaori Sugimoto, Kazuhiro Ohki, Naoki Sakura and Tadashi Hashimoto
Peptides 1998, ed. by S. Bajusz and F. Hudecz, Akadémiai Kiadó, Budapest   442-443   1999
A simple deblocking method of acetyl-peptide by aqueous methanesulfonic acid
Kazuhiro Ohki, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptides 1998, ed. by S. Bajusz and F. Hudecz, Akadémiai Kiadó, Budapest   440-441   1999
Regioselective Hydrolysis of Formyl-peptide in Aqueous Methanesulfonic Acid
Kumiko Hayashi, Kazuhiro Ohki, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptide Science 1998   141-144   1999
Regioselective hydrolytic cleavage of N-terminal myristoyl-peptide
Kaori Sugimoto, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptide Science—Present and Future, ed. by Y. Shimonishi, Kluwer Academic Pubrishers (UK)   158-160   1998
Regioselective Cleavage of Myristoyl-Peptide in Acidic Solution
Keiko Okimura, Kaori Sugimoto, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1996   89-92   1997
Sotoo Nagai, Keiko Okimura, Naohito Kaizawa, Kazuhiro Ohki and Shôichi Kanatomo
Chemical & Pharmaceutical Bulletin   44(1) 5-10   1996
Synthesis of surfactin B2 produced by Bacillus natto KMD 2311
Sotoo Nagai, Keiko Okimura, Naohito Kaizawa, Kazuhiro Ohki and Shoichi Kanatomo
Peptide Chemistry 1995   137-140   1996
Enzymatic degradation of rabbit neuromedin U-25 related peptides
Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1995   97-100   1996
Degradation of Rat neuromedin U-23 by Rat Serum Enzymes and Contractile Activity of Its Metabolites
Keiko Okimura and Tadashi Hashimoto
Peptide Chemistry 1994   321-324   1995
Structure-Activity Relationships of Neuromedin U-8 Analogs Modified at the N-Terminal Portions
Katsuro Kurosawa, Kazuhiro Ohki, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1993   237-240   1994
Keiko Okimura, Naoki Sakura, Satoru Ohta, Katsuro Kurosawa and Tadashi Hashimoto
Chem. Pharm. Bull.   40(6) 1500-1503   1992
Contractile Activity of Neuromedin U-8 Analogs Substituted at the Position 1
Katsuro Kurosawa, Akira Shibata, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1991   241   1992
Naoki Sakura, Satoru Ohta, Yoshiki Uchida, Katsuro Kurosawa, Keiko Okimura and Tadashi Hashimoto
Chem. Pharm. Bull.   39(8) 2016-2020   1991
Tadashi Hashimoto, Hiroko Masui, Yoshiki Uchida, Naoki Sakura and Keiko Okimura
Chem. Pharm. Bull.   39(9) 2319-2322   1991
Chain Length-contractile Activity Relationships of Neuromedin Us on Isolated Chick Crop Smooth Muscle
Keiko Okimura, Satoru Ohta, Katsuro Kurosawa, Akira Shibata, Yoshiki Uchida, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1990   235   1991
Contractile Activity of Rat Neuromedin U and Its Fragments on Isolated Smooth Muscle Preparations
Naoki Sakura, Satoru Ohta, Yoshiki Uchida, Keiko Okimura and Tadashi Hashimoto
Peptides 1990   655   1991
Antagonistic activities of neuromedin U-8 analogs on isolated smooth muscles
Yoshiki Uchida, Keiko Okimura, Hiroko masui, Naoki Sakura and Tadashi Hashimoto
Peptide Chemistry 1989   181   1990
Tissue Selectivity of Novel Specific and Competitive Antagonists of Neurokinin B on Isolated Smooth Muscles
Shigeru Naminohira, Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Takeshi Sakai, Naoki Sakura and Tadashi Hashimoto
Advances in Experimental Medicine and Biology   247B 401-406   1989
Tissue Selectivity of Novel Specific and Competitive Antagonists of Neurokinin B on Isolated Smooth Muscles
Shigeru Naminohira, Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Takeshi Sakai, Naoki Sakura and Tadashi Hashimoto
Advances in Experimental Medicine and Biology 247B   401-406   1989
Specific Antagonists of neurokininB analogs against Tachykinin Receptors
Naoki Sakura, Shigeru Naminohira, Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Takeshi Sakai and Tadashi Hashimoto
Peptide Chemistry 1987   557-560   1988
Tadashi Hashimoto, Yoshiki Uchida, Keiko Okimura, and Katsuro Kurosawa
Chem. Pharm. Bull.   35(8) 3442-3446   1987
Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Naoki Sakura, Kyoko Hirose and Tadashi Hashimoto
Bull. Chem. Soc. Jpn.   60(4) 1561-1563   1987

Conference Activities & Talks

 
Investigation of Antibacterial Activity of Short Linear or Cyclic Derivatives of Myticalin A6
OKIMURA Keiko
25 Oct 2019   
Implementation of a questionnaire survey aimed at promoting home healthcare (Survey at insurance pharmacies)
OKIMURA Keiko
23 Mar 2019   
Study on structure-activity relationship of antimicrobial peptide Myticalin A6 and its short chain derivatives
OKIMURA Keiko, MATSUBARA Keiko, ENDOH Yuriko, SATOH Ayumi
21 Mar 2019   
Development of Polymysin B3 Analogs with Hydroxy Amino Acids Substituting for its Diamino Butyric Acid Residues
uki Sato, Naoki Sakura, Tatsuo Takahashi, Keiko Okimura, Masakazu Miura, Keiichi Hatakeyama, Keiichi Ohshima, Toru Mochizuki
10th International Peptide Symposium   Dec 2018   
Investigation of Structure Activity Relationship of Derivatives of Antimicrobial Peptide Lacrain
Keiko Okimura, Keiko Matsubara, Yumi Iha and Yui Shimada
10th International Peptide Symposium   Dec 2018   
Synthesis of highly active derivative of an antimicrobial peptide Lacrain
OKIMURA Keiko
Mar 2018   
Study on the influence of temperature on the stability of insulin glargine in insulin glargine devices
OKIMURA Keiko
Mar 2017   
Build the Highly-Advanced Medical technology Pharmacist Education Program
Yoko Kubota, Osamu Oyama, Masaaki Nomura, Masanori Ohmoto, Tomomi Sugiyama, Keiko OKimura, Chieko Maida, Masakazu Miura
7th Asian Association of Schools of Pharmacy (AASP)   Oct 2015   
The support system of a hospital pharmacist training by a lot of students in Hokuriku University
OKIMURA Keiko
Mar 2013   
Investigation on the degree of understanding of biomedicals (2): Investigation for insulin
OKIMURA Keiko
Mar 2013   
The examination of the simple suspension method using the loxoprofen containing tablet
OKIMURA Keiko
Mar 2012   
Study on the Quality evaluation of the Drug Products
OKIMURA Keiko
Mar 2011   
Communication skills training for 3rd grade students of the 6-year undergraduate program in the Faculty of Pharmaceutical Sciences at Hokuriku University
OKIMURA Keiko
Mar 2009   
Development of polymyxin B (3-10) analogs with specific antimicrobial activity against Pseudomonas aeruginosa
OKIMURA Keiko
Mar 2009   
he semi-synthesis of polymyxin B (2-10) analogs employing the 9-fluorenylmethoxycarbonyl (Fmoc) group for side chain protection
OKIMURA Keiko
Mar 2009   
Antimicrobial Activity of Various Aminocyclohexylcarbonyl-polymyxin B (2-10) Derivatives
OKIMURA Keiko
Oct 2008   
Synthesis of cyclic neuromedin U analogs and their smooth muscle contractile activity
OKIMURA Keiko
Mar 2008   
Des-fatty acyl-polymyxin B decapeptide analogs with antimicrobial activity specifically against Pseudomonas aeruginosa
OKIMURA Keiko
Nov 2007   
LPS-binding Activity of Dancylated Polymyxin B Derivatives
OKIMURA Keiko
Mar 2007   
Semi-synthesis of colistin (2-10) analogs employing the trichloroethoxycarbonyl group for side chain protection
OKIMURA Keiko
Mar 2007   
Semi-Synthesis of Polymyxin B-(2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of 2,4-Diaminobutyric Acid Residues
Keiko Okimura, Kazuhiro Ohki, Yuki Sato, Kuniharu Ohnishi and Naoki Sakura
International Conference of 43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting   Nov 2006   
Synthesis and Antimicrobial Activity of Des-Fatty Acylated Polymyxin B Decapeptide N-Terminal Analogs
OKIMURA Keiko
Mar 2006   
Identification of [Nva7]-Polymyxin B1
OKIMURA Keiko
Mar 2006   
Semi-Synthesis of Acetyl- and Myristoyl-Polymyxin Nonapeptides from Natural Polymyxins
OKIMURA Keiko
Mar 2006   
Isolation and Structure Determination of [Ile7]- and [Ser2]-Polymyxin B1
OKIMURA Keiko
Oct 2005   
Structural analysis of partial acid hydrolysates of polymyxin B peptides
OKIMURA Keiko
Mar 2005   
Antimicrobial Activity of Des-Fatty Acyl-polymyxin B Decapeptide N-Terminal Analogs
Naoko Katsuma, Yuki Sato, Kazuhiro Ohki, Keiko Okimura, Yoshiki Uchida* Mitsuno Shindo* and Naoki Sakura
Asia-Pacific International Peptide Symposium/The 41st Japanese Peptide Symposium   Oct 2004   
Semi-synthesis of colistin nonapeptide derivatives from natural colistin
OKIMURA Keiko
Mar 2004   
Configrational examination of 3-hydroxy-6-methyloctanoic acid, polymyxin B6 component fatty acid
OKIMURA Keiko
Mar 2004   
Antimicrobial Activity of Polymyxin B3 Analogs Modified at the Hydrophobic Amino Acids
Kazushi Kanazawa, Kazuhiro Ohki, Keiko Okimura, Yuki Sato, Yoshiki Uchida* and Naoki Sakura
Oct 2003   
Chemical Conversion of Natural Polymyxin B to Polymyxin B Nonapeptide Derivatives
Keiko Okimura, Kazuhiro Ohki, Sotoo Nagai, Yoshiki Uchida* and Naoki Sakura
Oct 2003   
Synthesis and Antimicrobial Activity of Polymyxin B Component Peptides
Kazuhiro Ohki, Hiroyuki Sawanishi, Sotoo Nagai, Keiko Okimura, Yoshiki Uchida* and Naoki Sakura,
Oct 2001   
HPLC Analysis of Fatty Acylglycine in the Hydrolysates of N-Terminally Blocked Peptides by Fatty Acids
Keiko Okimura, Kazuhiro Ohki, Sotoo Nagai and Naoki Sakura
Oct 2000   
Regioselective hydrolysis of formyl-peptide in aqueous methanesulfonic acid
Kumiko hayashi, Kazuhiro Ohki, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
Oct 1998   
A simple deblocking method of acetyl-peptide by aqueous methanesulfonic acid
Kazuhiro Ohki, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
25th European Peptide Symposium   Aug 1998   
Regioselective cleavage of N-terminal myristoyl-peptide and the identification of the blocking group
Keiko Okimura, Kaori Sugimoto, Kazuhiro Ohki, Naoki Sakura and Tadashi Hashimoto
25th European Peptide Symposium   Aug 1998   
Regioselective Hydrolytic Cleavage of N-Terminal Myristoyl-Peptide
Kaori Sugimoto, Keiko Okimura, Naoki Sakura and Tadashi Hashimoto
1st International Peptide Symposium   Dec 1997   
Regioselective Cleavage of Myristoyl-Peptide in Acidic Solution
Keiko Okimura, Kaori Sugimoto, Naoki Sakura and Tadashi Hashimoto
Oct 1996   
Degradation of Rat neuromedin U-23 by Rat Serum Enzymes and Contractile Activity of its Metabolites
Keiko Okimura and Tadashi Hashimoto
Sep 1994   
Contractile activity of rat neuromedin U and its fragments on isolated smooth muscle preparations
Naoki Sakura, Satoru Ohta, Yoshiki Uchida, Keiko Okimura and Tadashi Hashimoto
The 21st European Peptide Symposium   Sep 1990   
Agonistic and Antagonistic Activities of Neuromedin U-8 Analogs on Isolated Smooth Muscles
Tadashi Hashimoto, Hiroko Masui, Naoki Sakura, Keiko Okimura, and Yoshiki Uchida
11th American Peptide Symposium   Jul 1989   
Specific Antagonists of Neurokinin B Analogs Against Tachykinin Receptors
Naoki Sakura, Sigeru Naminohira, Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Takeshi Sakai and Tadashi Hashimoto
Sep 1987   
Tissue Selectivity of Novel Specific and Competitive Antagonists of Neurokinin B on Isolated Smooth Muscles
Sigeru Naminohira, Yoshiki Uchida, Keiko Okimura, Katsuro Kurosawa, Takeshi Sakai, Naoki Sakura and Tadashi Hashimoto
5th International Congress on Kinin   Nov 1987   

Research Grants & Projects

 
Regioselective cleavage of myristoyl-peptide in acidic solution
Cooperative Research
Project Year: 1996 - 2003
Synthesis and antimicrobial activity of polymyxin B component peptides
Cooperative Research
Project Year: 2001   
Chemical Conversion of Natural Polymyxin B to Polymyxin B Nonapeptide Derivatives
Cooperative Research
Project Year: 2001   
Chemical Conversion of Natural Colisotin to Colistin Nonapeptide Derivatives
Cooperative Research
Project Year: 2003   
Semi-Synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of 2,4-Diaminobutyric Acid Residues
Project Year: 2005