Yukihiro B Hiraoka - My portal - researchmap

Profile Information

Affiliation: Professor, Graduate School of Oral Medicine, Graduate School of Oral Medicine, Matsumoto Dental University

Degree: Dr. of Science(Rikkyo University)

J-GLOBAL ID: 200901032677801139
researchmap Member ID: 1000098949

Research Interests

4

Research Areas

3

Research History

10

2002

- 松本歯科大学教授
2002

- Matsumoto Dental University, Professor
1986 - 2001

Matsumoto Dental University
1986 - 2001

Matsumoto Dental University, Assistant Professor
2001

- 松本歯科大学助教授
2001

- Matsumoto Dental University, Assosiate Professor
1986 - 1988

米国国立環境衛生研究所奨学研究員
1986 - 1988

NIEHS, NIH, Visiting Fellow
1975 - 1985

Matsumoto Dental University
1975 - 1985

Matsumoto Dental University, Research Associate

Education

2

- 1975

Department of Chemistry, College of Science, Rikkyo University
- 1975

Faculty of Science, Rikkyo University

Papers

4

Porphyromonas gingivalis SODにおける活性中心近傍に局在するアミノ酸残基の金属特異的活性における関与 Leu72 TrpおよびLeu76 Pheの2残基変異による検討(Contribution of the amino acid residues located near the active site metal to the metal-specific activity of Porphyromonas gingivalis SOD induced by a double mutation of Leu 72 Trp and Leu 76 Phe)

三原正志, 小町谷美帆, 溝上真也, 大澤雅樹, 上松節子, 菊池有一郎, 大久保裕一郎, 平井要, 黒岩昭弘, 山田一尋 …

松本歯学, 40(1) 26-34, Jun, 2014 Peer-reviewed
Effect of substituting Trp for Leu at position 72 on the structure of Porphyromonas gingivalis superoxide dismutase.

Miho Komachiya, Shinya Mizoue, Masashi Mihara, Masaki Osawa, Yuichiro Kikuchi, Setsuko Uematsu, Kaname Hirai, Yuichiro Okubo, Akihiro Kuroiwa, Kazuhiro Yamada …

40 19-25, 2014 Peer-reviewed
治療抵抗性歯周炎患者のアジスロマイシン投与における臨床的・細菌学的評価

佐藤哲夫, 藤波義明, 平岡行博, 荒敏昭, 窪川恵太, 海瀬聖仁, 武藤昭紀, 三木学, 岩井由紀子, 王宝禮 …

日歯保存誌, 56 239-251, 2013 Peer-reviewed
Aberrant TRPV1 expression in heat hyperalgesia associated with trigeminal neuropathic pain.

Urano H, Ara T, Fujinami Y, Hiraoka BY

Int J Med Sci., 9 690-697, 2012 Peer-reviewed

Misc.

29

Conversion of the metal-specific activity of Escherichia coli Mn-SOD by site-directed mutagenesis of Gly165Thr

Masaki Osawa, Fumiyuki Yamakura, Masashi Mihara, Yuichiro Okubo, Kazuhiro Yamada, B. Yukihiro Hiraoka

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804(9) 1775-1779, Sep, 2010
Immunoassay based on a polyclonal antibody for the quantification of Porphyromanas gingivalis SOD ： a preliminary report.

Masaki Osawa, Masashi Mihara, Yuichiro Kikuchi, Yuichiro Okubo, Kazuhiro Yamada, Kaname Hirai, B.Yukihiro Hiraoka

松本歯学, 36(1) 1-6, 2010
Detection of 6-nitrotryptophan in proteins by Western blot analysis and its application for peroxynitrite-treated PC12 cells.

Keiichi Ikeda, B. Yukihiro Hiraoka, Hideaki Iwai, Takashi Matsumoto, Reiko Mineki, Hikari Taka, Kenji Takamori, Hideoki Ogawa, Fumiyuki Yamakura

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 16(1) 18-28, Feb, 2007
Effects of substrate analogues and pH on manganese superoxide dismutases

LC Tabares, N Cortez, BY Hiraoka, F Yamakura, S Un

BIOCHEMISTRY, 45(6) 1919-1929, Feb, 2006
歯周病原菌の酸化ストレスに対するサバイバル戦略

平岡行博

松本歯学, 32 117-127, 2006
Manganese(II) zero-field interaction in cambialistic and manganese superoxide dismutases and its relationship to the structure of the metal binding site

S Un, LC Tabares, N Cortez, BY Hiraoka, F Yamakura

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(9) 2720-2726, Mar, 2004
Manganese(II) zero-field interaction in cambialistic and manganese superoxide dismutases and its relationship to the structure of the metal binding site

S Un, LC Tabares, N Cortez, BY Hiraoka, F Yamakura

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(9) 2720-2726, Mar, 2004
Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption

M Nakamura, N Udagawa, S Matsuura, M Mogi, H Nakamura, H Horiuchi, N Saito, BY Hiraoka, Y Kobayashi, K Takaoka …

ENDOCRINOLOGY, 144(12) 5441-5449, Dec, 2003
Pronounced conversion of the metal-specific activity of superoxide dismutase from Porphyromonas gingivalis by the mutation of a single amino acid (Gly155Thr) located apart from the active site

F Yamakura, S Sugio, BY Hiraoka, D Ohmori, T Yokota

BIOCHEMISTRY, 42(36) 10790-10799, Sep, 2003
Pronounced conversion of the metal-specific activity of superoxide dismutase from Porphyromonas gingivalis by the mutation of a single amino acid (Gly155Thr) located apart from the active site

F Yamakura, S Sugio, BY Hiraoka, D Ohmori, T Yokota

BIOCHEMISTRY, 42(36) 10790-10799, Sep, 2003
Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carsinomas.

Uematsu, T, Hasegawa, T, Hiraoka, B.Y, Komatsu, F, Matsuura, T, Yamada, A.-S, Yamaoka, M

Int. J. Cancer, 92(2) 187-194, 2001
Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carsinomas.

Int. J. Cancer., 92(2) 187-194, 2001
Crystal structure of cambialistic superoxide dismutase from Porphyromonas gingivalis

S Sugio, BY Hiraoka, F Yamakura

EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(12) 3487-3495, Jun, 2000
A change of the metal-specific activity of a cambialistic superoxide dismutase from Porphyromonas gingivalis by a double mutation of Gln-70 to Gly and Ala-142 to Gln.

Hiraoka, B.Y, Yamakura, F, Sugio, S, Nakayama, K

Biochem. J., 345(2) 345-350, 2000
Crystal structure of ambialistic superoxide dismutase from Porphyromonas gingivalis.

Sugio, S, Hiraoka, B.Y, Yamakura, F

Eur. J. Biochem., 267(12) 3487-3495, 2000
A double mutation of glutamine 70 to glycine and alanine 142 to glutamine partially changes metal-specific activity of a cambialistic superoxide dismutase from Porphyromonas gingivalis

Biochemical Journal, 345 345-350, 2000
Expression of transforming growth factor-beta peptide and its mRNA in chondrocytes in the early phase of BMP-induced heterotopic 'transchondroid bone formation'

T Kawakami, BY Hiraoka, T Kawai, N Takei, H Hasegawa, S Eda

MEDICAL SCIENCE RESEARCH, 27(6) 419-421, Jun, 1999
Inactivation and destruction of conserved Trp159 of Fe-superoxide dismutase from Porphyromonas gingivalis by hydrogen peroxide

F Yamakura, RL Rardin, GA Petsko, D Ringe, BY Hiraoka, K Nakayama, T Fujimura, H Taka, K Murayama

EUROPEAN JOURNAL OF BIOCHEMISTRY, 253(1) 49-56, Apr, 1998
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PROLYLCARBOXYPEPTIDASE ACTIVITY IN MONKEY KIDNEY

Y SUZAWA, BY HIRAOKA, M HARADA, T DEGUCHI

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 670(1) 152-156, Aug, 1995
Purification and characterization of tripeptide aminopeptidase from bovine dental follicles

Molecular and Callular Biochemistry, 129,87-92, 1993

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Books and Other Publications

3

Handbook of Proteolytic Enzymes, 2nd ed. Membrane Pro-X carboxypeptidase.

Elsevier Ltd, 2004
Handbook of Proteolytic Enzymes, 2nd ed. Membrane Pro-X carboxypeptidase.

Elsevier Ltd, 2004
Membrane Pro-X carboxypeptidase(共著)

Handbook of Proteolytic Enzymes, 1998

Professional Memberships

2

Research Projects

4