Akiko Sakai

Profile Information

Affiliation: Chemistry, Osaka Medical and Pharmaceutical University

Degree: Ph.D(Nagasaki University)

J-GLOBAL ID: 200901065718689565
researchmap Member ID: 1000106947

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Chemistry, Osaka Medical and Pharmaceutical University
2015 - Present

講師, 化学教室, 大阪医科大学
2007

講師（准）, 化学教室, 大阪医科大学
1995

学内講師, 化学教室, 大阪医科大学
1990

助手, 化学教室, 大阪医科大学

Papers

Reaction of threonine synthase with the substrate analogue 2-amino-5-phosphonopentanoate: implications into the proton transfer at the active site

Yasuhiro Machida, Takeshi Murakawa, Akiko Sakai, Mitsuo Shoji, Yasuteru Shigeta, Hideyuki Hayashi

The Journal of Biochemistry, 167(4) 357-364, Apr 1, 2020 Peer-reviewed
Comparative proteomic analysis of paclitaxel resistance-related proteins in human breast cancer cell lines

Hiroya Fujioka, Akiko Sakai, Satoru Tanaka, Kosei Kimura, Akiko Miyamoto, Mitsuhiko Iwamoto, Kazuhisa Uchiyama

ONCOLOGY LETTERS, 13(1) 289-295, Jan, 2017 Peer-reviewedCorresponding author
Comparative Proteome Analysis of Indomethacin-Treated Intestinal Cells Reveals Down-Regulation of Collagen I in NSAID-Induced Intestinal Injury

Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi

DIGESTION, 91(1) 90-90, 2015 Peer-reviewed
Down-Regulation of Collagen I Biosynthesis in Intestinal Epithelial Cells Exposed to Indomethacin: A Comparative Proteome Analysis

Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi

DIGESTIVE DISEASES AND SCIENCES, 59(9) 2016-2016, Sep, 2014 Peer-reviewed
Down-regulation of collagen I biosynthesis in intestinal epithelial cells exposed to indomethacin: A comparative proteome analysis

Shoko Edogawa, Akiko Sakai, Takuya Inoue, Satoshi Harada, Toshihisa Takeuchi, Eiji Umegaki, Hideyuki Hayashi, Kazuhide Higuchi

JOURNAL OF PROTEOMICS, 103 35-46, May, 2014 Peer-reviewed
YqjD Is an Inner Membrane Protein Associated with Stationary-Phase Ribosomes in Escherichia coli

Hideji Yoshida, Yasushi Maki, Shou Furuike, Akiko Sakai, Masami Ueta, Akira Wada

JOURNAL OF BACTERIOLOGY, 194(16) 4178-4183, Aug, 2012 Peer-reviewed
Identification of DNA mismatch recognition proteins in the thermophilic bacterium Geobacillus stearothermophilus

Matsunaga F, Sakai A, Mochizuki S, Minami K, Inatsu S

Bulletin of Toyo College of Food Technology, 1(1) 9-15, Mar, 2012
Identification of phosphorylated serine-15 and-82 residues of HSPB1 in 5-fluorouracil-resistant colorectal cancer cells by proteomics

Akiko Sakai, Mieko Otani, Akiko Miyamoto, Hideji Yoshida, Eisuke Furuya, Nobuhiko Tanigawa

JOURNAL OF PROTEOMICS, 75(3) 806-818, Jan, 2012 Peer-reviewedLead authorCorresponding author
The regulation of ciliary beat frequency by ovarian steroids in the guinea pig Fallopian tube: interactions between oestradiol and progesterone

Takashi Nakahari, Ayumi Nishimura, Chikao Shimamoto, Akiko Sakai, Hiroko Kuwabara, Takashi Nakano, Saori Tanaka, Yuka Kohda, Hitoshi Matsumura, Hiroshi Mori

BIOMEDICAL RESEARCH-TOKYO, 32(5) 321-328, Oct, 2011 Peer-reviewed
Phosphoproteome Profiling Using a Fluorescent Phosphosensor Dye in Two-Dimensional Polyacrylamide Gel Electrophoresis

Mieko Otani, Taizo Taniguchi, Akiko Sakai, Jouji Seta, Keiichi Kadoyama, Tooru Nakamura-Hirota, Shogo Matsuyama, Keiji Sano, Masaoki Takano

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 164(6) 804-818, Jul, 2011 Peer-reviewed
Proteomic analysis regarding resistance to anticancer drugs using a 5-fluorouracil-resistant human gastric cancer cell line and the radical-free and highly reducing method of two-dimensional electrophoresis

Ogata A, Wada A, Ueta M, Fushitani S, Tanaka S, Kimura K, Sakai A, Yoshida H, Miyamoto A, Fujita Y …

Bull Osaka Med Coll, 57(1) 31-38, Jan, 2011 Peer-reviewed
Differential display of the basic protein in 5-fluorouracil resistance of human colon cancer cell line using the radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis

Fushitani H, Wada A, Tanaka S, Kimura K, Ogata A, Miyamoto A, Sakai A, Tanigawa N

Bull Osaka Med Coll, 57(1) 39-48, Jan, 2011 Peer-reviewed
Comparative proteomic analysis of the ribosomes in 5-fluorouracil resistance of a human colon cancer cell line using the radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis

Kosei Kimura, Akira Wada, Masami Ueta, Akihiko Ogata, Satoru Tanaka, Akiko Sakai, Hideji Yoshida, Hideo Fushitani, Akiko Miyamoto, Masakazu Fukushima …

INTERNATIONAL JOURNAL OF ONCOLOGY, 37(5) 1271-1278, Nov, 2010 Peer-reviewed
Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells

Yukinori Sawabe, Chikao Shimamoto, Akiko Sakai, Hiroko Kuwabara, Adel H. Saad, Takashi Nakano, Kimitaka Takitani, Hiroshi Tamai, Hiroshi Mori, Yoshinori Marunaka …

EXPERIMENTAL PHYSIOLOGY, 95(8) 858-868, Aug, 2010 Peer-reviewed
11. Use of a phosphosensor dye in proteomic analysis of human mutant tau transgenic mice

Takano M, Otani M, Sakai A, Kadoyama K, Matsuyama S, Matsumoto A, Takenokuchi M, Sumida M, Taniguchi T

Neuroreport, 20(18) 1648-1653, Dec, 2009 Peer-reviewed
Activities of Escherichia coli ribosomes in IF3 and RMF change to prepare 100S ribosome formation on entering the stationary growth phase

Hideji Yoshida, Masami Ueta, Yasushi Maki, Akiko Sakai, Akira Wada

GENES TO CELLS, 14(2) 271-280, Feb, 2009 Peer-reviewed
Proteomic analysis of the basic proteins in 5-fluorouracil resistance of human colon cancer cell line using the radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis

Satoru Tanaka, Akiko Saka, Kousei Kimura, Hideji Yoshida, Hideo Fushitani, Akihito Ogata, Akiko Miyamoto, Masakazu Fukushima, Akira Wada, Nobuhiko Tanigawa

INTERNATIONAL JOURNAL OF ONCOLOGY, 33(2) 361-370, Aug, 2008 Peer-reviewed
プロテオミクスを用いた癌細胞株における抗癌剤耐性に対する研究

田中覚, 境晶子, 吉田秀司, 野原丈裕, 岩本充彦, 住吉一浩, 原田知明, 木村光誠, 和田明, 谷川允彦

日本乳癌学会総会プログラム抄録集, 15回 276-276, Jun, 2007
Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase

Fuyo Tsukiyama, Yumi Nakai, Masataka Yoshida, Takahiro Tokuhara, Kiichi Hirota, Akiko Sakai, Hideyuki Hayashi, Takahiro Katsumata

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351(1) 234-239, Dec, 2006 Peer-reviewed
Angiotensin-II receptor blocker exerts cardioprotection in diabetic rats exposed to hypoxia

S Inamoto, T Hayashi, N Tazawa, T Mori, C Yamashita, D Nakano, Y Matsumura, N Okuda, K Sohmiya, A Sakai …

CIRCULATION JOURNAL, 70(6) 787-792, Jun, 2006 Peer-reviewed

Misc.

プロテオーム解析を用いた,インドメタシン起因性小腸粘膜傷害における発現蛋白の検討

江戸川祥子, 梅垣英次, 原田智, 楢林賢, 藤原薫, 小嶋融一, 太田和寛, 竹内利寿, 井上拓也, 樋口和秀 …

日本潰瘍学会プログラム・抄録集, 41st 80, 2013
内膜およびリボソームに結合する大腸菌蛋白質YqjDの特性

吉田秀司, 牧泰史, 古池晶, 境晶子, 上田雅美, 和田明

日本分子生物学会年会プログラム・要旨集(Web), 34th, 2011
HP-031-1 RFHR2次元電気泳動法を用いた,大腸癌細胞株における5-FU体制に関連する塩基性蛋白の解析(大腸がん(基礎研究1),ハイブリッドポスター,第109回日本外科学会定期学術集会)

田中覚, 境晶子, 木村光誠, 吉田秀司, 尾方章人, 福島正和, 和田明, 谷川允彦

日本外科学会雑誌, 110(2) 447-447, Feb 25, 2009
GraFix法により安定化した100SリボソームのcryoEMによる構造解析

加藤貴之, 吉田秀司, 牧泰史, 古池晶, 上田雅美, 境晶子, 和田明, 難波啓一

日本RNA学会年会要旨集, 11th, 2009

Teaching Experience

Professional Memberships

Research Projects

抗癌剤耐性関連タンパク質HSPB1の構造機能相関の解明とその臨床応用

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2017 - Mar, 2022

境晶子, 田中覚
Elucidation of structure-function relationship of HSPB1 in anticancer drug resistance mechanism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

SAKAI AKIKO
Proteomic analysis of chemotherapy resistance related proteins in human breast cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Tanaka Satoru, Sakai Akiko
Elucidation and application of the 5FU resistant mechanism of breast cancer using proteomic analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KIMURA Kosei, SAKAI Akiko, TANAKA Satoru, FUJIOKA Hiroya
Studies on the molecular mechanism of 5-fluorouracil response proteins using a proteomic approach

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

SAKAI Akiko, TANAKA Satoru
Proteomic analysis of oxidative stress-responsive proteins in metabolic syndrome

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

SAKAI Akiko, HAYASHI Tetsuya, YOSHIDA Hideji
Elucidation of E.coli 100S ribosome structure and formation mechanisms

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

YOSHIDA Hideji, MAKI Yasushi, SAKAI Akiko
Human proteomics by the high-powered RFHR 2D PAGE for detection of protein changes resistant to anticancer agents

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

WADA Akira, WADA Chieko, UETA Masami, SAKAI Akiko, YOSHIDA Hideji, MAKI Yasushi, TANIGAWA Nobuhiko, FURUYA Eisuke
塩基性蛋白質に着目した抗癌剤5-フルオロウラシル耐性マーカーの同定と診断法の予備的検討

JST地域イノベーション創出総合支援事業, 2007

境晶子
One protein/cell proteomics by the high power RFHR-2D-PAGE

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2005

WADA Akira, YOSHIDA Hideji, SAKAI Akiko
フルクトース2.6二燐酸合成酵素に起因する脳と腎臓の臓器特異的な糖代謝調節

科学研究費助成事業一般研究(C), 一般研究(C), 日本学術振興会, 1992 - 1992

古谷栄助, 境晶子
Proteome analysis of 5-fluorouracil-resistance-associated proteins

Cooperative Research

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

Menu

Coauthors