HAYASHI Hideyuki

J-GLOBAL         Last updated: Dec 14, 2019 at 23:08
 
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Name
HAYASHI Hideyuki
Affiliation
Osaka Medical College
Section
Department of Chemistry
Job title
Professor
Degree
Doctor of Medical Science(Osaka University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2004
 - 
Today
Professor, Osaka Medical College
 
Apr 1994
 - 
Mar 2004
Senior Associate Professor, Osaka Medical College
 
Feb 1988
 - 
Mar 1994
Associate Professor, Osaka Medical College
 
Apr 1987
 - 
Feb 1988
Assistant Professor, Osaka University
 
Apr 1986
 - 
Mar 1987
Postdoctoral Fellow, JSPS
 

Education

 
 
 - 
1986
Physiology, Graduate School of Medicine, Osaka University
 
 
 - 
1986
Graduate School, Division of Medicine, Osaka University
 
 
 - 
1982
Division of Medicine, Faculty of Medicine, Osaka University
 

Awards & Honors

 
1998
Award for Young Scientist from the Japan Society of Vitaminology
 

Published Papers

 
Machida Y, Murakawa T, Sakai A, Shoji M, Shigeta Y, Hayashi H
Journal of biochemistry      Nov 2019   [Refereed]
Kulikova VV, Revtovich SV, Bazhulina NP, Anufrieva NV, Kotlov MI, Koval VS, Morozova EA, Hayashi H, Belyi YF, Demidkina TV
IUBMB life   71(11) 1815-1823   Nov 2019   [Refereed]
Murakawa T, Baba S, Kawano Y, Hayashi H, Yano T, Kumasaka T, Yamamoto M, Tanizawa K, Okajima T
Proc. Natl. Acad. Sci. U.S.A.   116    Jan 2019   [Refereed]
Ujiie Y, Tanaka W, Hanaoka K, Harada R, Kayanuma M, Shoji M, Murakawa T, Ishida T, Shigeta Y, Hayashi H
J. Phys. Chem. B   121(22) 5536-5543   Jun 2017   [Refereed]
Kobayashi J, Yoshida H, Yagi T, Kamitori S, Hayashi H, Mizutani K, Takahashi N, Mikami B
J. Biosci. Bioeng.   123(2) 154-162   Apr 2017   [Refereed]
Murakawa T, Hamaguchi A, Nakanishi S, Kataoka M, Nakai T, Kawano Y, Yamaguchi H, Hayashi H, Tanizawa K, Okajima T
J. Biol. Chem.   290(38) 23094-23109   Sep 2015   [Refereed]
Uchida Y, Hayashi H, Washio T, Yamasaki R, Kato S, Oikawa T
Extremophiles   18(3) 589-602   May 2014   [Refereed]
Edogawa S, Sakai A, Inoue T, Harada S, Takeuchi T, Umegaki E, Hayashi H, Higuchi K
J. Proteomics   103 35-46   May 2014   [Refereed]
Shoji M, Hanaoka K, Ujiie Y, Tanaka W, Kondo D, Umeda H, Kamoshida Y, Kayanuma M, Kamiya K, Shiraishi K, Machida Y, Murakawa T, Hayashi H
J. Am. Chem. Soc.   136(12) 4525-4533   Mar 2014   [Refereed]
Murakawa T, Hayashi H, Sunami T, Kurihara K, Tamada T, Kuroki R, Suzuki M, Tanizawa K, Okajima T
Acta Crystallogr. D. Biol. Crystallogr.   69(Pt12) 2483-2494   Dec 2013   [Refereed]
Ishii S, Yano T, Okamoto A, Murakawa T, Hayashi H
Biochemistry   52(15) 2545-2555   Apr 2013   [Refereed]
Nakai Y, Harada A, Hashiguchi Y, Nakai M, Hayashi H
J. Biol. Chem.   287(36) 30874-30884   Aug 2012   [Refereed]
Murakawa T, Hayashi H, Taki M, Yamamoto Y, Kawano Y, Tanizawa K, Okajima T
J. Biochem.   151(2) 167-178   Feb 2012   [Refereed]
Lowther J, Charmier G, Raman MC, Ikushiro H, Hayashi H, Campopiano DJ
FEBS Lett.   585(12) 1729-1734   Jun 2011   [Refereed]
Moya-Garcia AA, Rodriguez-Agudo D, Hayashi H, Medina MA, Urdiales JL, Sanchez-Jimenez F
J. Chem. Theory Comput.   7(6) 1935-1942   May 2011   [Refereed]
Murakawa T, Machida Y, Hayashi H
J. Biol. Chem.   286(4) 2774-2784   Jan 2011   [Refereed]
Omi R, Kurokawa S, Mihara H, Hayashi H, Goto M, Miyahara I, Kurihara T, Hirotsu K, Esaki N
J. Biol. Chem.   285(14) 12133-12139   Apr 2010   [Refereed]
Ishii S, Yano T, Ebihara A, Okamoto A, Manzoku M, Hayashi H
J. Biol. Chem.   285(14) 10777-10785   Apr 2010
Ikushiro H, Islam MM, Okamoto A, Hoseki J, Murakawa T, Fujii S, Miyahara I, Hayashi H
J. Biochem.   146(4) 549-562   Oct 2009   [Refereed]
Shiraiwa Y, Ikushiro H, Hayashi H
J. Biol. Chem.   284(23) 15487-15495   Jun 2009   [Refereed]
Nakai Y, Nakai M, Hayashi H
J. Biol. Chem.   283(41) 27469-27476   Oct 2008   [Refereed]
Taki M, Murakawa T, Nakamoto T, Uchida M, Hayashi H, Tanizawa K, Yamamoto Y, Okajima T
Biochemistry   47(29) 7726-7733   Jun 2008
Ikushiro H, Fujii S, Shiraiwa Y, Hayashi H
J. Biol. Chem.   283(12) 7542-7553   Mar 2008
Kotake Y, Ishii S, Yano T, Katsuoka Y, Hayashi H
Biochemistry   47(8) 2531-2538   Feb 2008   [Refereed]
Yoshikane, Y, Yokochi, N, Yamasaki, M, Mizutani, K, Ohnishi, K, Mikami, B, Hayashi, H, Yagi, T
J. Biol. Chem.   283(2) 1120-1127   Jan 2008
Ikushiro H, Islam MM, Tojo H, Hayashi H
J. Bacteriol.   189(15) 5749-5761   Aug 2007   [Refereed]
Nakai Y, Nakai M, Lill R, Suzuki T, Hayashi H
Mol. Cell. Biol.   27(8) 2841-2847   Apr 2007   [Refereed]
Tsukiyama F, Nakai Y, Yoshida M, Tokuhara T, Hirota K, Sakai A, Hayashi H, Katsumata T
Biochem. Biophys. Res. Commun.   351(1) 234-239   Dec 2006   [Refereed]
Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T
J. Biol. Chem.   281(45) 34365-34373   Nov 2006   [Refereed]
Yoshikane Y, Yokochi N, Ohnishi K, Hayashi H, Yagi T
Biochem. J.   396(3) 499-507   Jun 2006
Murakawa T, Okajima T, Kuroda S, Nakamoto T, Taki M, Yamamoto Y, Hayashi H, Tanizawa K
Biochem. Biophys. Res. Commun.   342(2) 414-423   Apr 2006
Chiu YC, Okajima T, Murakawa T, Uchida M, Taki M, Hirota S, Kim M, Yamaguchi H, Kawano Y, Kamiya N, Kuroda S, Hayashi H, Yamamoto Y, Tanizawa K
Biochemistry   45(13) 4105-4120   Apr 2006
Islam MM, Goto M, Miyahara I, Ikushiro H, Hirotsu K, Hayashi H
Biochemistry   44(23) 8218-8229   Jun 2005   [Refereed]
Katsura Y, Shirouzu M, Yamaguchi H, Ishitani R, Nureki O, Kuramitsu S, Hayashi H, Yokoyama S
Proteins   55(3) 487-492   May 2004
Goto M, Omi R, Miyahara I, Hosono A, Mizuguchi H, Hayashi H, Kagamiyama H, Hirotsu K
J. Biol. Chem.   279(13) 16518-16525   Apr 2004   [Refereed]
Nakai Y, Umeda N, Suzuki T, Nakai M, Hayashi H, Watanabe K, Kagamiyama H
J. Biol. Chem.   279(13) 12363-12368   Mar 2004   [Refereed]
Ikushiro H, Hayashi H, Kagamiyama H
Biochemistry   43(4) 1082-1092   Feb 2004   [Refereed]
Matsuda N, Hayashi H, Miyatake S, Kuroiwa T, Kagamiyama H
J. Biochem.   135(1) 33-42   Jan 2004   [Refereed]
Hosono A, Mizuguchi H, Hayashi H, Goto M, Miyahara I, Hirotsu K, Kagamiyama H
J. Biochem.   134(6) 843-851   Dec 2003   [Refereed]
Omi R, Goto M, Miyahara I, Mizuguchi H, Hayashi H, Kagamiyama H, Hirotsu K
J. Biol. Chem.   278(46) 46035-46045   Nov 2003   [Refereed]
Islam MM, Hayashi H, Kagamiyama H
J. Biochem.   134(2) 277-285   Aug 2003   [Refereed]
Mizuguchi H, Hayashi H, Miyahara I, Hirotsu K, Kagamiyama H
Biochim. Biophys. Acta   1647(1,2) 321-324   Apr 2003   [Refereed]
Goto M, Miyahara I, Hayashi H, Kagamiyama H, Hirotsu K
Biochemistry   42(13) 3725-3733   Apr 2003   [Refereed]
Hayashi H, Mizuguchi H, Miyahara I, Nakajima Y, Hirotsu K, Kagamiyama H
J. Biol. Chem.   278(11) 9481-9488   Mar 2003   [Refereed]
Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling.
Omi R, Mizuguchi H, Goto M, Miyahara I, Hayashi H, Kagamiyama H, Hirotsu K
J. Biochem.   132(5) 759-765   Nov 2002   [Refereed]
Spectroscopic analysis of recombinant rat histidine decarboxylase.
Olmo MT, Sanchez-Jimenez F, Medina MA, Hayashi H
J. Biochem.   132(3) 433-439   Sep 2002   [Refereed]
Watanabe A, Yoshimura T, Mikami B, Hayashi H, Kagamiyama H, Esaki N
J. Biol. Chem.   277(21) 19166-19172   May 2002   [Refereed]
Nakayama, T, Sato, T, Fukui, Y, Yonekura-Sakakibara, K, Hayashi, H, Tanaka, Y, Kusumi, T, Nishino, T
FEBS Lett.   499(1,2) 107-111   Jun 2001   [Refereed]
Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, Kagamiyama H
Biochemistry   40(15) 4633-4644   Apr 2001   [Refereed]
Nakai Y, Nakai M, Hayashi H, Kagamiyama H
J. Biol. Chem.   276(11) 314-320   Mar 2001   [Refereed]
Matharu A, Hayashi H, Kagamiyama H, Maras B, John RA
Eur. J. Biochem.   268(6) 1640-1645   Mar 2001   [Refereed]
Mizuguchi H, Hayashi H, Okada K, Miyahara I, Hirotsu K, Kagamiyama H
Biochemistry   40(2) 353-360   Jan 2001   [Refereed]
Islam MM, Hayashi H, Mizuguchi H, Kagamiyama H.
Biochemistry   39(50) 15418-15428   Dec 2000
Kurita, M, Matsumoto, M, Tsuji, S, Kawakami, M, Suzuki, Y, Hayashi, H, Toyoshima, K, Seya, T
Clin. Exp. Immunol.   116(3) 547-553   Jun 1999   [Refereed]
Nakai Y, Yoshihara Y, Hayashi H, Kagamiyama H.
FEBS Lett.   433(1,2) 143-148   Aug 1998   [Refereed]
Ishii S, Hayashi H, Okamoto A, Kagamiyama H.
Protein Sci.   7(8) 1802-1810   Aug 1998   [Refereed]
Okamoto A, Nakai Y, Hayashi H, Hirotsu K, Kagamiyama H.
J. Mol. Biol.   280(3) 443-461   Jul 1998   [Refereed]
Usui, H, Inoue, R, Tanabe, O, Nishito, Y, Shimizu, M, Hayashi, H, Kagamiyama, H, Takeda, M
FEBS Lett.   430(3) 312-316   Jul 1998   [Refereed]
Kishikawa, M. Nakanishi, T. Miyazaki, A. Hatanaka, M. Shimizu, A. Tamoto, S. Ohsawa, N. Hayashi, H. Kanai, M.
Human mutation   12(5) 363-363   May 1998   [Refereed]
Ikushiro H, Hayashi H, Kawata Y, Kagamiyama H.
Biochemistry   37(9) 3043-3052   Mar 1998   [Refereed]
OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons.
Yoshihara Y, Kawasaki M, Tamada A, Fujita H, Hayashi H, Kagamiyama H, Mori K
J. Neurosci.   17(15) 5830-5842   Aug 1997
Three-dimensional structure of Escherichia coli branched-chain amino acid aminotransferase at 2.5 angstrom resolution.
Okada K, Hirotsu K, Sato M, Hayashi H, Kagamiyama H
J. Biochem.   121(4) 637-641   May 1997
An anomalous side reaction of the Lys303 mutant aromatic L-amino acid decarboxylase unravels the role of the residue in catalysis.
Nishino J, Hayashi H, Ishii S, Kagamiyama H.
J. Biochem.   121(3) 604-611   Mar 1997
Mollova, E T, Metzler, D E, Kintanar, A, Kagamiyama, H, Hayashi, H, Hirotsu, K, Miyahara, I
Biochemistry   36(2) 615-625   Jan 1997   [Refereed]
Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes.
Ariki M, Tanabe O, Usui H, Hayashi H, Inoue R, Nishito Y, Kagamiyama H, Takeda M
J. Biochem.   121(1) 104-111   Jan 1997
Paracoccus denitrificans aromatic amino acid aminotransferase: A model enzyme for the study of dual substrate recognition mechanism.
Oue S, Okamoto A, Nakai Y, Nakahira M, Shibatani T, Hayashi H, Kagamiyama H
J. Biochem.   121(1) 161-171   Jan 1997
Nakai Y, Hayashi H, Kagamiyama H
Biochim. Biophys. Acta   1308(3) 189-192   Sep 1996
Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis.
Ishii S, Mizuguchi H, Nishino J, Hayashi H, Kagamiyama H
J. Biochem.   120(2) 369-376   Aug 1996
Gekko K, Tamura Y, Ohmae E, Hayashi H, Kagamiyama H, Ueno H
Protein Sci.   5(3) 542-545   Mar 1996   [Refereed]
Tanabe O, Nagase T, Murakami T, Nozaki H, Usui H, Nishito Y, Hayashi H, Kagamiyama H, Takeda M
FEBS Lett.   379(1) 107-111   Jan 1996
Purification and characterization of [3H]-mepyramine (histamine H1 antagonist)-binding protein from rat liver: A highly homologous protein with cytochrome P450 2D.
Fukui H, Mizuguchi H, Liu YQ, Wang NP, Hayashi H, Kangawa K, Wakamiya T, Leurs R, Shiba T, Matsuo H
J. Biochem.   117(5) 993-998   May 1995
NMR studies of 1H resonances in the 10-18-ppm range for aspartate aminotransferase from Escherichia coli.
Metzler DE, Metzler CM, Scott RD, Mollova ET, Kagamiyama H, Yano T, Kuramitsu S, Hayashi H, Hirotsu K, Miyahara I
J. Biol. Chem.   269(45) 28027-28033   Nov 1994
X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferase from Escherichia coli in three forms.
Miyahara I, Hirotsu K, Hayashi H, Kagamiyama H
J. Biochem.   116(5) 1001-1012   Nov 1994
Ohta K, Hayashi H, Mizuguchi H, Kagamiyama H, Fujimoto K, Fukui H
Biochem. Biophys. Res. Commun.   203(2) 1096-1101   Sep 1994
Aspartate aminotransferase from a thermophilic formate-utilizing methanogen, Methanobacterium thermoformicicum strain SF-4: Relation to serine and phosphoserine aminotransferases but not to aspartate aminotransferase family.
Tanaka T, Yamamoto S, Moriya T, Taniguchi M, Hayashi H, Kagamiyama H, Oi S
J. Biochem.   115(2) 309-317   Feb 1994
Hayashi H, Inoue K, Nagata T, Kuramitsu S, Kagamiyama H
Biochemistry   32(45) 12229-12239   Nov 1993   [Refereed]
Hayashi H, Mizuguchi H, Kagamiyama H
Biochemistry   32(3) 812-818   Jan 1993   [Refereed]
Tanaka T, Yamamoto S, Taniguchi M, Hayashi H, Kuramitsu S, Kagamiyama H, Oi S
J. Biochem.   112(6) 811-815   Dec 1992
Kawasaki Y, Hayashi H, Hatakeyama K, Kagamiyama H
Biochem. Biophys. Res. Commun.   186(3) 1242-1248   Aug 1992
Kuramitsu S, Hiromi K, Hayashi H, Morino Y, Kagamiyama H
Biochemistry   29(23) 5469-5476   Jun 1990
Hayashi H, Inoue Y, Kuramitsu S, Morino Y, Kagamiyama H
Biochem. Biophys. Res. Commun.   167(2) 407-412   May 1990
Hayashi H, Kuramitsu S, Inoue Y, Morino Y, Kagamiyama H
Biochem. Biophys. Res. Commun.   159(1) 337-342   Feb 1989
Ando-Yamamoto, M., Kiyama, H., Hayashi, H., Fukui, H., Tohyama, M., Watanabe, T., & Wada, H.
Brain Res.   410(2) 269-274   May 1987
Masuda T, Sakamoto M, Nishizaki I, Hayashi H, Yamamoto M, Wada H
J. Biochem.   101(3) 643-652   Mar 1987
Ando-Yamamoto, M., Hayashi, H., Sugiyama, T., Fukui, H., Watanabe, T., & Wada, H.
J. Biochem.   101(2) 405-414   Feb 1987
Ando-Yamamoto, M., Hayashi, H., Taguchi, Y., Fukui, H., Watanabe, T., & Wada, H.
Biochem. Biophys. Res. Commun.   141(1) 306-312   Nov 1986
Sakamoto Y, Watanabe T, Hayashi H, Taguchi Y, Wada H
Agents Actions   17(1) 32-37   Oct 1985
Hayashi H, Takagi H, Takeda N, Kubota Y, Tohyama M, Watanabe T, Wada H
J. Comp. Neurol.   229(2) 233-241   Oct 1984

Misc

 
Ikushiro H, Hayashi H
Biochim. Biophys. Acta   1814(11) 1474-1480   Nov 2011   [Refereed]
Hayashi H, Tanase S, Yagi T
J. Biochem.   147 451-457   Apr 2010   [Refereed]
Ikushiro H, Hayashi H, Kagamiyama H
Biochim. Biophys. Acta   1647(1,2) 116-120   Apr 2003   [Refereed]
Hayashi H, Mizuguchi H, Miyahara I, Islam MM, Ikushiro H, Nakajima Y, Hirotsu K, Kagamiyama H
Biochim. Biophys. Acta   1647(1,2) 103-109   Apr 2003   [Refereed]
Pyridoxal enzymes : Mechanistic diversity and uniformity.
Hayashi H
J.Biochem.   118(3) 463-473   Sep 1995

Books etc

 
Branched-chain amino-acid aminotransferase of Escherichia coli
Methods. Enzymol.   2000   
Recent topics in pyridoxal 5'-phosphate enzyme studies
Annu. Rev. Biochem.   1990   

Research Grants & Projects

 
Mechanism of Enzyme Functions
Grants and Funding
Project Year: 2004 - 2005
Kinetic analysis of enzyme catalysis
Grants and Funding
Project Year: 2006 - 2006
Theoretical analysis of enzyme catalysis
Grants and Funding
Project Year: 2006 - 2006