論文

査読有り
2014年4月

Synergistic Antitumor Effect of a Combination of Paclitaxel and Carboplatin with Nobiletin from Citrus depressa on Non-Small-Cell Lung Cancer Cell Lines

PLANTA MEDICA
  • Shinichi Uesato
  • Hirofumi Yamashita
  • Ryu Maeda
  • Yoshiyuki Hirata
  • Maho Yamamoto
  • Saki Matsue
  • Yasuo Nagaoka
  • Makio Shibano
  • Masahiko Taniguchi
  • Kimiye Baba
  • Motoharu Ju-ichi
  • 全て表示

80
6
開始ページ
452
終了ページ
457
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1055/s-0034-1368321
出版者・発行元
GEORG THIEME VERLAG KG

Non-small-cell lung carcinomas do not sufficiently respond to cancer chemotherapeutic drugs. Combination effects of cancer chemotherapy drugs (paclitaxel and carboplatin) with nobiletin or powdered Shiikuwasha extract from Citrus depressa were examined by isobologram and combination index analyses. It was demonstrated that the combination generated a synergistic inhibitory effect against the proliferation of the human non-small-cell lung carcinoma cell lines A549 and H460 and that of the two chemotherapy drugs, paclitaxel was responsible for this synergistic effect. Furthermore, the percentage of apoptotic cells was decreased with increasing rates of nobiletin to paclitaxel and carboplatin. These findings were considered to be attributed to the ability of nobiletin to regulate cells in the G(1) phase, which escaped cell death initiated by paclitaxel and carboplatin. An antitumor activity assay showed that this combination significantly suppressed the growth of subcutaneous A549 tumor xenografts in nude mice.

リンク情報
DOI
https://doi.org/10.1055/s-0034-1368321
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24687742
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000334856900002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1055/s-0034-1368321
  • ISSN : 0032-0943
  • eISSN : 1439-0221
  • PubMed ID : 24687742
  • Web of Science ID : WOS:000334856900002

エクスポート
BibTeX RIS