Toshimasa Ishida - My portal - researchmap

Profile Information

Affiliation: professor, Faculty of Pharmaceutical Sciences, Faculty of Pharmaceutical science, Osaka University of Pharmaceutical Sciences

Degree: Ph.D(Osaka University)

J-GLOBAL ID: 200901031810632624
researchmap Member ID: 1000108329

External link: http://www.oups.ac.jp

Research Interests

6

Research Areas

7

Research History

3

1979 - 1980

アレキサシダーフォンフシホルト財団による奨学研究員
1979 - 1980

Fellowship of Alexander von Humboldt-Stifturg
(西ドイツへ留学)

Education

4

Committee Memberships

4

Awards

5

2008

日本薬学会学術貢献賞
2008

The PSJ Award for Divisional Scientific Promotions
1996

Twentieth Century Achievement Award
1988

日本薬学会奨励賞
1988

Promotion Award for Japan Pharmaceutical Society

Misc.

380

Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E

Atsuo Mizuno, Yasuko In, Yuki Fujita, Fumi Abiko, Hiroo Miyagawa, Kunihiro Kitamura, Koji Tomoo, Toshimasa Ishida

FEBS LETTERS, 582(23-24) 3439-3444, Oct, 2008
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain

Masaki Hattori, Etsuko Sugino, Katsuhiko Minoura, Yasuko In, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 374(1) 158-163, Sep, 2008
Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin

Koji Tomoo, Yasuhiro Mukai, Yasuko In, Hiroo Miyagawa, Kunihiro Kitamura, Akihito Yamano, Heisaburo Shindo, Toshimasa Ishida

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1784(7-8) 1059-1067, Jul, 2008
Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein

Kayoko Okuyama, Chisato Nishiura, Fumie Mizushima, Katsuhiko Minoura, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishida

FEBS JOURNAL, 275(7) 1529-1539, Apr, 2008
Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution

Fumie Mizushima, Katsuhiko Minoura, Koji Tomoo, Aliho Sumida, Taizo Taniguchi, Toshimasa Ishida

JOURNAL OF BIOCHEMISTRY, 142(1) 49-54, Jul, 2007
Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis

Fumi Abiko, Koji Tomoo, Atsuo Mizuno, Shigenobu Morino, Hiroaki Imataka, Toshimasa Ishida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 355(3) 667-672, Apr, 2007
Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes

Daiya Watanabe, Atsushi Yamamoto, Koji Tomoo, Keita Matsumoto, Mitsuo Murata, Kunihiro Kitamura, Toshimasa Ishida

JOURNAL OF MOLECULAR BIOLOGY, 362(5) 979-993, Oct, 2006
Effect of N-terminal Region of eIF4E and Ser65-phosphorylation of 4E-BP1 on interaction between eIF4E and 4E-BP1 fragment peptide

Koji Tomoo, Fumi Abiko, Hiroo Miyagawa, Kunihiro Kitamura, Toshimasa Ishida

JOURNAL OF BIOCHEMISTRY, 140(2) 237-246, Aug, 2006
Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study

M Kamigauchi, Y Noda, J Nishijo, K Iwasaki, K Tobetto, Y In, K Tomoo, T Ishida

BIOORGANIC & MEDICINAL CHEMISTRY, 13(5) 1867-1872, Mar, 2005
Conformational transition state is responsible for assembly of microtubule-binding domain of tau protein

S Hiraoka, TM Yao, K Minoura, K Tomoo, M Sumida, T Taniguchi, T Ishida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 315(3) 659-663, Mar, 2004
Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain

K Minoura, TM Yao, K Tomoo, M Sumida, M Sasaki, T Taniguchi, T Ishida

EUROPEAN JOURNAL OF BIOCHEMISTRY, 271(3) 545-552, Feb, 2004
Function of AGCA tetrads in (CAG)n repeats

Nucleic Acid Res Supp., No. 2, 291-292, 2004
Structural scaffold of 18-crown-6 tetracarboxylic acid for optical resolution of chiral amino acid: X-ray crystal analyses and energy calculations of complexes of D- and L-isomers of tyrosine, isoleucine, methionine and phenylglycine

H Nagata, H Nishi, M Kamigauchi, T Ishida

ORGANIC & BIOMOLECULAR CHEMISTRY, 2(23) 3470-3475, 2004
Conformational analysis of four repeat fragments in tau microtubule binding domain

Peptide Science, 2002, 371-374, 2004
Analysis of aggrebation mechanism of microtubule binding domain in tau protein

Peptide Science, 2003, 303-306, 2004
Novel 1-D water nanowires in crystal of an organic host

Chem. Lett., 33, 354-355, 2004
Berberine Inclusion Structure of g-Cyclodextrin, Studied by 1H-NMR Spectroscopy and Molecular Dynamics Calculation

Helv. Chim. Acta, 87, 264-271, 2004
Berberine Inclusion Structure of g-Cyclodextrin, Studied by 1H-NMR Spectroscopy and Molecular Dynamics Calculation

Helv. Chim. Acta, 87, 264-271, 2004
Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods

TM Yao, K Tomoo, T Ishida, H Hasegawa, M Sasaki, T Taniguchi

JOURNAL OF BIOCHEMISTRY, 134(1) 91-99, Jul, 2003
Difference between enzymatic and chemical N-methylations of protoberberine-type alkaloid, dependent on the stereoisomer of (-)-N-methyl-7,8,13,13a-tetrahydroberberinium salt

M Kamigauchi, M Yoshida, Y Noda, J Nishijo, Y In, K Tomoo, H Ohishi, T Ishida

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 76(3) 587-593, Mar, 2003

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Books and Other Publications

6

ベーシック薬学教科書シリーズ物理化学

化学同人, 2007
物理系薬学 I.物質の物理的性質

東京化学同人, 2004
タンパク質と核酸の分離精製

廣川書店, 2001
プロテアーゼインヒビターの基礎と応用 4 システインプロテアーゼインヒビター-構造化学的な見地から-

治療学, 1998
製剤物理化学

廣川書店, 1992
薬学のための物理化学

化学同人

Professional Memberships

10

Works

6

Research Projects

14

ＡＴＰ依存性等輸送タンパク質ＢｘＩＤの構造ー機能解析

ライフサイエンス基礎科学研究, 2002
Structure-function analysis of ATP-dependent transporter protein BxID

Basic Science Research on Life Science, 2002
タウタンパク質の立体構造解析に基づくタングル形成機構の解明

ライフサイエンス基礎科学研究, 2000
Analysis of Tangle Formation Mechanism baced on Three-dimensional Structure of Tau

Global Environment Research Fund, 2000
酵素阻害剤の分子設計

ライフサイエンス基礎科学研究, 1990
Molecular Design of Enzyme Inhibitor

The Other Research Programs, 1990
生理活性ペプチドの構造−活性相関

ライフサイエンス基礎科学研究, 1980
タンパク質生合成開始因子の構造機能解析

官民交流共同研究, 1980
Structure-Activity Relationship of Bioactive Peptides

Improvement of Technical Infrastructure SCF Promotion System for Intellectual Infrastructure of Research and Development, 1980
Analysis of Structural Function of Protein Synthesis Intiation Factor

0106 (Japanese Only), 1980
医薬品のX線結晶構造解析
生体機能分子の立体構造解析
X-ray arsstal structure analysis of drug
Three-dimensional structure analysis of bioactive molecular