FUJII Shinobu

J-GLOBAL         Last updated: Nov 6, 2018 at 17:25
 
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Name
FUJII Shinobu
Affiliation
Osaka University of Pharmaceutical Sciences
Section
Faculty of Pharmaceutical Sciences, Department of Biochemistry
Job title
Associate Professor
Degree
Master of Pharmaceutical Sciences(Osaka University of Pharmaceutical Sciences), Doctor of Pharmaceutical Sciences(Kyoto University)

Research Areas

 
 

Academic & Professional Experience

 
1989
 - 
1992
Setsunan University, Research Worker
 

Education

 
 
 - 
1989
Graduate School, Division of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
 
 
 - 
1987
Faculty of Pharmaceutical Science, Setsunan University
 

Published Papers

 
Reiko Ueoka, Yoichi Nakao, Yoichi Nakao, Shinobu Fujii, Rob W M Van Soest, Shigeki Matsunaga
Journal of Natural Products   71 1089-1091   Jun 2008
Three sesterterpenoids, aplysinoplides A-C (1-3), were isolated from the marine sponge Aplysinopsis digitata. Their structures were determined on the basis of spectroscopic data. They exhibited cytotoxic activity against P388 mouse leukemia cells....
Atsushi Furukawa, Kouzou Kita, Misao Toyomoto, Shinobu Fujii, Seiji Inoue, Kyozo Hayashi, Kiyoshi Ikeda
Molecular and Cellular Biochemistry   305 27-34   Nov 2007
The NGF secretion from cultured mouse astrocytes was enhanced by sublethal concentrations of phosphatidic acid (PA), ceramide, or sphingosine (Sph), and concentration dependently by lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC), o...
Toshikazu Hakogi, Tetsuya Yamamoto, Shinobu Fujii, Kiyoshi Ikeda, Shigeo Katsumura
Tetrahedron Letters   47 2627-2630   Apr 2006
As a new sphingomyelinase inhibitor, a novel sphingomyelin CF2 analogue was designed and synthesized. One key step of this synthesis is the very mild hydrolysis of the oxazolidinone ring, a suitable intermediate for the introduction of a diethyl d...
Fujii S, Itoh H, Yoshida A, Higashi S, Ikezawa H, Ikeda K
Archives of biochemistry and biophysics   436(2) 227-236   Apr 2005   [Refereed]
Hakogi T, Fujii S, Morita M, Ikeda K, Katsumura S
Bioorganic & medicinal chemistry letters   15(8) 2141-2144   Apr 2005   [Refereed]
Shinobu Fujii, Ayumi Yoshida, Saori Sakurai, Michio Morita, Kikuo Tsukamoto, Hiroho Ikezawa, Kiyoshi Ikeda
Biol. Pharm. Bull.   27(11) 1725-1729   Nov 2004
We developed a convenient chromogenic assay method for the activity of sphingomyelinase (SMase) from Bacillus cereus. SMase reaction was quenched by Zn2+, and the released phosphocholine was converted into a choline by the action of alkaline phosp...
Fujii S, Nagata M, Morita M, Minoura K, Tsukamoto K, Ikezawa H, Ikeda K
Archives of biochemistry and biophysics   424(2) 201-209   Apr 2004   [Refereed]
Takashi Obama, Shinobu Fujii, Hiroh Ikezawa, Kiyoshi Ikeda, Masayoshi Imagawa, Kikuo Tsukamoto
Biol. Pharm. Bull.   26(7) 920-926   Jul 2003
Bacillus cereus sphingomyelinase belongs to the Mg2+-dependent neutral sphingomyelinase, which hydrolyses sphingomyelin to phosphocholine and ceramide, and acts as an extracellular hemolysin. The triplet residues, His151-Asp195-His296, of the enzy...
スフィンゴミエリナーゼ:セラミド産生に関わる酵素
Foods & Food Ingredients Journal of Japan   203, 17-26    2002
HAKOGI T, MONDEN Y, TAICHI M, IWAMA S, FUJII S, IKEDA K, KATSUMURA S
Journal of Organic Chemistry   67(14) 4839-4846   2002

Misc

 
Roles of Asp126 and Asp156 in the Enzyme Function of Sphingomyelinase from Bacillus cereus
J. Biochem.   126(1) 90-97   1999
Chemical Modification and Inactivation of Phospholipases A2 by a Manoalide Analogue
Biochem. J.   308(1) 297-304   1995
Binding Mode of Phospholipase A2 with a New Type of Phospholipid Analog having on Oxazolidinone Ring.
J, Biochem,   117(1) 176-182   1995
Role of CA2+in the Binding of Phospholipase A2 with a Monomeric Substrate and with Its' Amide-Type Analog
J, Biochem   116(4) 870-876   1994

Works

 
Elcidation of the Catalytic Mechanism of Phosphalipases
1993

Research Grants & Projects

 
Elucidation of the Catalytic Mechanism of Phospholipases