論文

査読有り
2014年11月

Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation

INTERNATIONAL JOURNAL OF HEMATOLOGY
  • Satoshi Ueda
  • ,
  • Naoki Sakata
  • ,
  • Hideki Muramatsu
  • ,
  • Hirotoshi Sakaguchi
  • ,
  • Xinan Wang
  • ,
  • Yinyan Xu
  • ,
  • Seiji Kojima
  • ,
  • Toshihiro Yamaguchi
  • ,
  • Takeshi Higa
  • ,
  • Tsukasa Takemura

100
5
開始ページ
502
終了ページ
506
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12185-014-1638-3
出版者・発行元
SPRINGER JAPAN KK

Juvenile myelomonocytic leukemia (JMML) is a mixed myeloproliferative and myelodysplastic disorder that occurs in early childhood. The clinical course of JMML is highly variable. A third of patients follow a relatively indolent course, although approximately 15 % cases are thought to develop acute myeloid leukemia, referred to as blast crisis. The etiology and clinical characteristics of blast crisis remain unclear. We document the case of a 27-month-old boy who presented with hepatosplenomegaly, skin rash, and lymphadenopathy. An initial diagnosis of acute erythroid leukemia was made according to the French-American-British classification. Following estimation of hypersensitivity to GM-CSF and genetic analysis of PTPN11, he was diagnosed with JMML in the blast crisis phase. Although he had several poor prognostic factors, including monosomy 7 and high HbF percentage, he achieved partial remission after treatment with acute myeloid leukemia-oriented chemotherapy followed by allogeneic hematopoietic stem cell transplantation.

リンク情報
DOI
https://doi.org/10.1007/s12185-014-1638-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25047104
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000345079600016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12185-014-1638-3
  • ISSN : 0925-5710
  • eISSN : 1865-3774
  • PubMed ID : 25047104
  • Web of Science ID : WOS:000345079600016

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