SEKIGUCHI Fumiko

J-GLOBAL         Last updated: Sep 20, 2018 at 18:32
 
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Name
SEKIGUCHI Fumiko
Affiliation
Kindai University
Section
Faculty of Pharmacy, Department of Pharmacy
Job title
Associate Professor
Degree
Ph.D.(Kinki University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2008
 - 
Today
Associate Professor, Pharmacology and Pathophysiology, Kinki University School of Pharmacy
 
Apr 2007
 - 
Mar 2008
lecturer, Pharmacology and Pathophysiology, Kinki University School of Pharmacy
 
2002
 - 
2003
Assistant Professor, Dept. Anat. and Physiol.,
 
2003
   
 
- Assistant Professor, Div. Phisio. and Pathophysiol.,
 
1991
 - 
2002
Instructor, Dept. Anat. and Physiol.,
 

Education

 
 
 - 
1991
School of Pharmaceutical Sciences, The University of Tokushima
 

Published Papers

 
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
SEKIGUCHI Fumiko, DOMOTO Risa, NAKASHIMA Kana, YAMASOBA Daichi, YAMANISHI Hiroki, TSUBOTA Maho, WAKE Hidenori, NISHIBORI Masahiro, KAWABATA Atsufumi
Neuropharmacology   141 201-213   Sep 2018   [Refereed]
Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice.
Sekiguchi Fumiko, Fujita Tomoyo, Deguchi Takahiro, Yamaoka Sakura, Tomochika Ken, Tsubota Maho, Ono Sumire, Horaguchi Yamato, Ichii Maki, Ichikawa Mio, Ueno Yumiko, Koike Nene, Tanino Tadatoshi, Nguyen Huy Du, Okada Takuya, Nishikawa Hiroyuki, Yoshida Shigeru, Ohkubo Tsuyako, Toyooka Naoki, Murata Kazuya, Matsuda Hideaki, Kawabata Atsufumi.
Neuropharmacology   138 232-244   Aug 2018   [Refereed]
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
Du Nguyen Huy, Okada Takuya, Kitamura Shum, Yamaoka Sakura, Horaguchi Yamato, Kasanami Yoshihito, Sekiguchi Fumiko, Tsubota Maho, Yoshida Shigeru, Nishikawa Hiroki, Kawabata Atsufumi, Toyooka Naoki
Bioorg Med Chem.   19 4410-4427   Jul 2018   [Refereed]
Hayashi Y, Tsujita R, Tsubota M, Saeki H, Sekiguchi F, Honda G, Kawabata A.
Biochem Biophys Res Commun.   495(1) 634-638   Jun 2018   [Refereed]
Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice.
Tsujita R, Tsubota M, Hayashi Y, Saeki H, Sekiguchi F, Kawabata A. Role of Thrombin in Soluble Thrombomodulin-Induced Suppressio
J Neuroimmune Pharmacol.   13(2) 179-188   Jun 2018   [Refereed]
Tsubota M, Okawa Y, Irie Y, Maeda M, Ozaki T, Sekiguchi F, Ishikura H, Kawabata A.
Neuropharmacology   133 254-263   May 2018   [Refereed]
Ozaki T, Tsubota M, Sekiguchi F, Kawabata A.
Clin Exp Pharmacol Physiol.   45(4) 355-361   Apr 2018   [Refereed]
Ozaki T, Matsuoka J, Tsubota M, Tomita S, Sekiguchi F, Minami T, Kawabata A.
Toxicology   393 102-112   Jan 2018   [Refereed]
Tsubota M, Ozaki T, Hayashi Y, Okawa Y, Fujimura A, Sekiguchi F, Nishikawa H, Kawabata A.
J Pharmacol Sci.   136(1) 46-49   Jan 2018   [Refereed]
Involvement of Voltage-Gated Calcium Channels in Inflammation and Inflammatory Pain.
Sekiguchi F, Tsubota M, Kawabata A.
Biol Pharm Bull.   41(8) 1127-1134   2018   [Invited]
Functional regulation of ion channels by H2S and its pathological impact
SEKIGUCHI Fumiko, KAWABATA Atsufumi
70(5) 61-70   May 2017   [Invited]
Repeated cold stress reduces cyclophosphamide-induced cystitis/bladder pain and macrophage activity in mice.
Tsubota, M., Miyamoto, T., Hiruma, S., Saeki, H., Miyazaki, T., Sekiguchi, F., Funakami, Y., Kawabata, A.
Pharmacology   99(5-6) 286-290   Mar 2017   [Refereed]
Tacrolimus triggers TRPV1-dependent relapse of pancreatitis-related pain in mice
Terada Y, Tsubota M, Sugo H, Wakitani K, Sekiguchi F, Wada K, Takada M, Oita A, Kawabata A.
Pharmacology   99 281-285   Mar 2017   [Refereed]
Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis.
Irie Y, Tsubota M, Ishikura H, Sekiguchi F, Terada Y, Tsujiuchi T, Liu K, Nishibori M, Kawabata A.
J Neuroimmune Pharmacol.   in press    2017   [Refereed]
Fukami K, Sekiguchi F, Kawabata A
Pharmacology   99 107-114   2017   [Refereed]
Sekiguchi F, Kawara Y, Tsubota M, Kawakami E, Ozaki T, Kawaishi Y, Tomita S, Kanaoka D, Yoshida S, Ohkubo T, Kawabata A.
Pain   157(8) 1655-1665   Aug 2016   [Refereed]
Nishida T, Tsubota M, Kawaishi Y, Yamanishi H, Kamitani N, Sekiguchi F, Ishikura H, Liu K, Nishibori M, Kawabata A.
Toxicology   365 48-58   Jul 2016   [Refereed]
Mitani K, Sekiguchi F, Maeda T, Tanaka Y, Yoshida S, Kawabata A.
J Pharmacol Sci.   130(3) 177-180   Mar 2016   [Refereed]
Yamasoba D, Tsubota M, Domoto R, Sekiguchi F, Nishikawa H, Liu K, Nishibori M, Ishikura H, Yamamoto T, Taga A, Kawabata A.
J Pharmacol Sci.   130(2) 139-142   Feb 2016   [Refereed]
Aoki Y, Tsubota M, Nishimoto Y, Maeda Y, Sekiguchi F, Kawabata A.
J Pharmacol Sci.   130(2) 38-41   Jan 2016   [Refereed]
Sekiguchi F, Sekimoto T, Ogura A, Kawabata A.
Biol. Pharm. Bull.   39(5) 887-890   2016   [Refereed]
Fukami, K., Sekiguchi, F., Yasukawa, M., Asano, E., Kasamatsu, R., Ueda, M., Yoshida, S., Kawabata, A.
Biochem. Pharmacol.   97 300-309   2015   [Refereed]
Terada, Y., Fujimura, M., Nishimura, S., Tsubota, M., Sekiguchi, F., Kawabata, A.
J. Neurosci. Res.   93 361-369   2015   [Refereed]
Murakami-Nakayama, M., Tsubota, M., Hiruma, S., Sekiguchi, F., Matsuyama, K., Kimura, T., Moriyama, M., Kawabata, A.
J. Pharmacol. Sci.   127 223-228   2015   [Refereed]
Maeda Y, Sekiguchi F, Yamanaka R, Sugimoto R, Yamasoba D, Tomita S, Nishikawa H, Kawabata A
Biological Chemistry   396 153-162   2015   [Refereed]
Tanaka J, Yamaguchi K, Ishikura H, Tsubota M, Sekiguchi F, Seki Y, Tsujiuchi T, Murai A, Umemura T, Kawabata A.
Neuropharmacology   79 112-118   Apr 2014   [Refereed]
Sekiguchi, F., Miyamoto, Y., Kanaoka, D., Ide, H., Yoshida, S., Ohkubo, T., Kawabata, A.
Biochem. Biophys. Res. Commun.   445 225-229   Feb 2014   [Refereed]
Tanaka J, Seki Y, Ishikura H, Tsubota M, Sekiguchi F, Yamaguchi K, Murai A, Umemura T, Kawabata A.
Br J Pharmacol.   170 1233-1241   Nov 2013   [Refereed]
Terada, Y., Fujimura, M., Nishimura, S., Tsubota, M., Sekiguchi, F., Nishikawa, H. and Kawabata, A.
J. Pharmacol. Sci.   123 284-287   Oct 2013   [Refereed]
SEKIGUCHI Fumiko, KAWABATA Atsufumi
J Pharmacol Sci.   122 244-250   Aug 2013   [Refereed][Invited]
Nishikawa H, Hayashi H, Kubo S, Tsubota-Matsunami M, Sekiguchi F, Kawabata A.
Biol Pharm Bull.   36(8) 1278-1282   Aug 2013   [Refereed]
Takahashi T, Okubo K, Kojima S, Nishikawa H, Takemura M, Tsubota-Matsunami M, Sekiguchi F, Kawabata A.
J Pharmacol Sci.   122(1) 51-54   Apr 2013   [Refereed]
Sekiguchi F, Aoki Y, Nakagawa M, Kanaoka D, Nishimoto Y, Tsubota-Matsunami M, Yamanaka R, Yoshida S, Kawabata A.
Br J Pharmacol.   168 734-745   Feb 2013   [Refereed]
Biochemcal and biophysical research communications   377(2) 622-626   Dec 2008
Kawabata A, Matsunami M, Sekiguchi F.
Br J Pharmacol   153 S230-S240   Aug 2008   [Invited]
British Journal of Pharmacology   153 S230-S240   Mar 2008
Sekiguchi F, Takaoka K, Kawabata A.
Inflammopharmacology   15(6) 246-251   Dec 2007   [Refereed][Invited]
Pain   132(1-2) 74-81   Nov 2007
Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues
Ann N Y Acad Sci   1091 115-459   Dec 2006
Endothelium-derived relaxing factor - nitric oxide and hypertension.
SUNANO Satoru, SEKIGUCHI Fumiko
Yakugaku Zasshi   123(7) 495-515   Jun 2003   [Invited]
Gastric relaxation by inhibitory neurotransmitters in hypertensive rats
SHIMAMURA Keiichi, KIMURA S., SEKIGUCHI Fumiko, SUNANO Satoru, SAITO H.
Biomed. Res.   14(1) 62-69   Apr 2003   [Refereed]
Caffeine-induced relaxation is unimpaired in the aorta of stroke-prone spontaneously hypertensive rats(SHRSP)
11 131-142   Mar 2003
Effects of drugs which act on the sarcoplasmic reticulum in the esophageal striated muscles from normotensive and spontaneously hypertensive rats
23(4・5) 131-144   Dec 2002
Hypertension and impairment of endothelium dependent relaxation of arteries from spontaneously hypertensive and L NAME treated Wistar rats
(10) 33-45   Mar 2002
Arterial smooth muscle tone and its modification by endothelium in spontaneously hypertensive rats.
SUNANO Satoru, SEKIGUCHI Fumiko, SHIMAMURA Keiichi
Biomed. Res.   11 137-147   2000   [Refereed][Invited]
SHIMAMURA Keiichi, SEKIGUCHI Fumiko, SUNANO Satoru
Clin. Exper. Pharmacol. Physiol.   26 275-284   1999   [Invited]
Abnormality of the endothelium-dependent and -independent tension oscillation in the artery of spontaneously hypertensive rats.
SHIMAMURA Keiichi, SEKIGUCHI Fumiko, SUNANO Satoru
J. Smooth Muscle Res. (Japanese Section),   2 J-99-J116   1999   [Invited]
SUNANO Satoru, SEKIGUCHI Fumiko, MATSUDA Kyoko, SHIMAMURA Keiichi
J. Smooth Muscle Res. (Japanese Section),   1 J-101-J-116   1997   [Invited]
Shimamura, K., Matsuda, K., Sekiguchi, F. and Sunano, S.
J. Smooth Muscle Res.   32 145-154   Aug 1996   [Refereed]
Spontaneous and agonist-induced contractions and endothelium-dependent relaxation in aortae from SHRSP and WKY rats under various levels of passive force.
SEKIGUCHI FumikoSekiguchi, F., Adachi, T., Matsubara, H., Matsuda, K., Kita, K., Shimamura, K. & Sunano, S.
Clin. Exp. Pharmacol. Physiol.   23 483-489   Jun 1996   [Refereed]
Sekiguchi, F., Shimamura, K., Akashi, M. and Sunano, S.
Br J Pharmacol.   118(4) 857-864   Jun 1996   [Refereed]
Sunano, S., Zou, L.-B., Matsuda, K., Sekiguchi, F., Watanabe, H. and Shimamura, K.
J. Cardiovasc. Pharmacol.   27 733-739   May 1996   [Refereed]
Neural responses of rat abdominal skin artery.
Shimamura, K., Akagi, K., Yamamoto, K., Sekiguchi, F. and Sunano, S.
J. Smooth Muscle Res.   31 397-399   Dec 1995   [Refereed]
Sunano, S., Sasaki, F. (now SEKIGUCHI Fumiko), Osugi, S., Shimamura, K.
J. Smooth Muscle Res.   30 135-145   Aug 1995   [Refereed]
Matsuda, K., Sekiguchi, F. (now SEKIGUCHI Fumiko), Tojo, M., Shimamura, K., Sunano, S.
J. Smooth Muscle Res.   31 51-60   Apr 1995   [Refereed]
Shibata, H., Odahara, Y., Sasaki, F. (now SEKIGUCHI Fumiko), Hirata, O., Nishida, M., Tani, I.
Microbiol. Immunol.   38(7) 519-525   1994   [Refereed]
Effect of treatment on the enhanced spontaneous tonus in the arterial smooth muscle of spontaneously hypertensive rats.
SUNANO Satoru, SASAKI Fumiko (now SEKIGUCHI Fumiko)
J. Smooth Muscle Res. (Japanese Section),   29 111-130   1993   [Invited]
Sasaki, F. (now SEKIGUCHI Fumiko), Osugi, S., Shimamura, K and Sunano, S.
J. Smooth Muscle Res.   29 69-79   1993   [Refereed]

Misc

 
Effects of endothelium- and smooth muscle-derived nitric oxide and arachidonic acid metabolites on norepinephrine-induced contraction of rat aorta (共著)
Alpha-Adrenoceptor   254-257    1992
Fumiko SASAKI, S. OSUGI, K. SHIMAMURA, S. SUNANO
J. Smooth Muscle Research   29(3) 69-79   1993
Ca2+-dependent active tone and blood pressure in various spontaneously hypertensive rats (共著)
Journal of Muscle Research and Cell Motility   15(3) 362   1994
Roles of extra- and intracellular Ca in aortic smooth muscle tone of spontaneously hypertensive rats (共著)
Journal of Muscle Research and Cell Motility   14(3) 373   1994

Books etc

 
Inhibitory role of nitric oxide in the contraction of circular muscle of rat portal vein(共著)
The Bioloby of Nitric Oxide Part 6 Portland Press Ltd, London   1998   

Conference Activities & Talks

 
Pulmonary arterial pressure of WKY and SHRSP
Jul 2000   
Mechanisms underlying contraction/relaxation caused by activation of protease-activated receptors 1 and 2 in rat superior mesenteric artery.
XVIIth International Congress on Fibrinolysis and Proteolysis   Mar 2004   XVIIth International Congress on Fibrinolysis and Proteolysis
Roles of protease-activated receptor-1 and -2 in modulation of mouse gastrointestinal motility.
XVIIth International Congress on Fibrinolysis and Proteolysis   Mar 2004   XVIIth International Congress on Fibrinolysis and Proteolysis
Signal transduction mechanisms for prostanoid formation caused by protease-activated receptor-2 activation in human lung epithelial cells.
XVIIth International Congress on Fibrinolysis and Proteolysis   Mar 2004   XVIIth International Congress on Fibrinolysis and Proteolysis
Protease-activated receptor-2 activation induces delayed facilitation of capsaicin-evoked visceral pain in mice: involvement of endogenous bradykinin.
11th International Pain Clinic World Society of Pain Clinicians   Jul 2004   11th International Pain Clinic World Society of Pain Clinicians

Association Memberships

 
 

Research Grants & Projects

 
Study on the role of nuclear protein HMGB1 in the process of neurite regeneration after nerve injury
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): SEKIGUCHI Fumiko
Study on the physiological role of endogenous hydrogen sulfide in the stomach with mucosal injury
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): SEKIGUCHI Fumiko
Involvement of T-type calcium channels and calcineurin in the inflammatory and neuropathic pain
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2011 - Mar 2014    Investigator(s): SEKIGUCHI Fumiko
Effects of Helicobacter pylori on expression levels and function of proteinase-activated receptors in the gastric mucosal epithelial cells
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2008 - Mar 2011    Investigator(s): SEKIGUCHI Fumiko
Study on mechanisms for modulation of gastrointestinal motility by G-protein-coupled proteinase-activated receptors
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2004 - Mar 2006    Investigator(s): SEKIGUCHI Fumiko