SUGIMOTO Naoki

J-GLOBAL         Last updated: May 21, 2019 at 09:21
 
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Name
SUGIMOTO Naoki
URL
http://www.konan-fiber.jp
Affiliation
Konan University
Section
Faculty of Frontiers of Innovative Research in Science and Technology, Department of Nanobiochemistry
Job title
Professor
Degree
Ph.D(Kyoto University), M.S.(Kyoto University)
Other affiliation
Konan University
Research funding number
60206430

Research Areas

 
 

Academic & Professional Experience

 
2003
 - 
2009
Konan University, Fontier Institute for Biomolecular Engineering Research (FIBER)
 
2009
   
 
- Konan University, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST)
 
2001
 - 
2003
Konan University, High-technology cener, Director
 
2001
   
 
- Konan University High Technology Research Center, Director
 
1991
 - 
1994
Konan University, Associate Professor
 
1994
   
 
- Konan University, Professor
 
1988
 - 
1991
Konan University, Assistant Professor
 
1985
 - 
1988
Rochester University, Research Associate
 

Education

 
 
 - 
1985
Graduate School, Division of Natural Science, Kyoto University
 
 
 - 
1979
Faculty of Science, Kyoto University
 

Awards & Honors

 
Sep 2018
The Imbach-Townsend Award, IS3NA(International Society for Nucleosides, Nucleotides, and Nucleic Acids)
 
Jun 2016
Keynote Lecture Award, European Chemistry Congress (Euro Chemistry2016)
 

Published Papers

 
RNA-Capturing Microsphere Particles (R-CAMPs) for Optimization of Functional Aptamers
T. Endoh, T. Ohyama, and N. Sugimoto
Small   in press    Apr 2019   [Refereed]
Lighting up of thiazole orange on G-quadruplex DNA by high pressure
S. Bhowmik, S. Takahashi, and N. Sugimoto
ACS Omega   4 1081-1093   2019   [Refereed]
Bisubstrate function of RNA polymerases triggered by molecular crowding conditions
S. Takahashi, H. Okura, and N. Sugimoto
Biochemistry   58 1081-1093   2019   [Refereed]
Validation of the Nearest-neighbor Model for Watson–Crick Self-complementary DNA Duplexes in Molecular Crowding Condition
S. Ghosh, S. Takahashi, T. Endoh, H. Tateishi-Karimata, S. Hazra, N. Sugimoto
Nucleic Acids Res.   47 3284-3294   2019   [Refereed]
Characterization of intracellular crowding environments with topology-based DNA quadruplex sensors
S. Takahashi, J. Yamamoto, A. Kitamura, M. Kinjo, and N. Sugimoto
Anal. Chem.   91(4) 2586-2590   Feb 2019   [Refereed]
Design and Properties of Ligand-Conjugated Guanine Oligonucleotides for Recovery of Mutated G-Quadruplexes
S. Takahashi, B. Chelobanov, K. T. Kim, B. H. Kim, D. Stetsenko, and N. Sugimoto
Molecules   23 3228   Dec 2018   [Refereed]
C-rich sequence in a non-template DNA strand regulates structure change of G-quadruplex in a template strand during transcription
Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
Bull. Chem. Soc. Jpn.   92(3) 572-577   2019   [Refereed]
An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
K. Kawauchi, W. Sugimoto, T. Yasui, K. Murata, K. Itoh, K. Takagi, T. Tsuruoka, K. Akamatsu, H. Tateishi-Karimata, N. Sugimoto, and D. Miyoshi
Nat. Commun.   9 2271   2018   [Refereed]
A Turn-On Detection of DNA Sequences by Means of Fluorescence of DNA-Templated Silver Nanoclusters via Unique Interactions of a Hydrated Ionic Liquid
Y. Teng, H. Tateishi-Karimata, T. Tsuruoka, and N. Sugimoto
Molecules   23 2889   2018   [Refereed]
Destabilization of DNA G-quadruplexes by chemical environment changes during tumor progression facilitates transcription
Y. Teng, S. Pramanik, H. Tateishi-Karimata, T. Ohyama, and N. Sugimoto
139    2018   [Refereed]
SUGIMOTO Naoki
Proc. Natl. Acad. Sci. U. S. A.   114 9605-9610   2017   [Refereed]

Misc

 
平成の化学キーワード 核酸の多様性を生みだすもう一つの塩基対相互作用 フーグスティーン塩基対
高橋俊太郎、杉本直己
化学同人   74(5) 24-25   Apr 2019   [Invited]
Effect of LNA modification on the thermal stability of non-canonical DNA structures
Nucleic Acids Symp. Ser. (Oxf).   54 172-173   2010
Roles of Anionic Functional Groups in G-quadruplex-ligands for Efficient Telomerase Inhibition
Nucleic Acids Symp. Ser. (Oxf).   54 148-149   2010
Unpaired region affecting hydration state of duplex
Nucleic Acids Symp. Ser. (Oxf).   54 210-211   2010
Construction of detection system for amyloid beta peptide localization and aggregation using fluorescent and luminescent fusion proteins
Peptide Science   2009 111-112   2010
DNA junction structure stabilized by molecular crowding conditions
Nucleic Acids Symp,Ser (Oxf)   53 59-60   2009
Naoki Sugimoto
Bull. Chem. Coc. Jpn.   82(1) 1-10   2009
Thermal stability and hydration state of DNA G-quadruplex regulated by loop regions
Nucleic Acids Symp,Ser (Oxf)   53 237-238   2009
Thermodynamics of DNA structures under molecular crowding conditions with neutral and positive charged cosolutes
Nucleic Acids Symp. Ser.   (52) 41-414   2009
Applied Biochem. Biotech.   160(8) 2458-2466   2009
Investigations of the cation binding to nucleotides by monitoring the hairpin-duplex equilibrium of a self-complementary sequence
Nucleic Acids Symp,Ser.   53 229-230   2009
Enhanced amplification of polymerase chain reaction by addition of cosolutes derived from a cellular compatible solute
Nucleic Acids Symp. Ser.   52(52) 257-258   2008
Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme
Nucleic Acids Symp. Ser.   52(52) 519-520   2008
Biochimie   90(7) 1040-1051   2008
Angew. Chem. Int. Ed.   (47) 9034-9038   2008
Nucleosides, Nucleotides, and Nucleic Acids   (27) 292-308   2008
Kazuya Koumoto, Hirofumi Ochiai, Naoki Sugimoto
Chem. Lett.   37(8) 864-865   2008
Effects of cosolutes on the thermodynamic stability of parallel DNA duplex and triplex.
Nucleic Acids Symp. Ser.   51(51) 167-168   2007
Conformational switch of a functional nanowire based on the DNA G-quadruplex.
Nucleic Acids Symp. Ser.   51(51) 251-252   2007
Functionalization of DNA by the base pair-mimic nucleosides.
Nucleic Acids Symp. Ser.   51(51) 151-152   2007
The base-pairing ability of the base pair-mimic nucleosides.
Nucleic Acids Symp. Ser.   51(51) 71-72   2007
Nucleic Acids Res.   35(12) 4086-4093   2007
Nucleosides, Nucleotides and Nucleic Acids   in press    2007

Books etc

 
Effect of ionic liquid and liposomes on the structure, stability, and function of nucleic acids
Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications (Springer)   May 2014   
Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowing: beyond the Watson-Crick double helix
SUGIMOTO Naoki
2014   
Thermodynamics and kinetics of Base-pairing of DNA and RNA Self-assembly and Helix-coil Transition
Nucleic Acids(Springer-Verlag)   1990   
RNA Structure Prediction.
Annual Review of Biophysics and Biophysical Chemistry.   1988   
Improved parameters for prediction of RNA secondary structure and insights into why RNA forms double helixes.
Structure and Dynamics of RNA(P.H.van Knippenbergand C.W.Hibers, Eds) Plenum Press   1986   

Conference Activities & Talks

 
Functions of Non-canonical Nucleic Acids (2) [Invited]
N. Sugimoto
International Workshop“Trends in Nucleic Acid (TINA) 2019”   12 Apr 2019   
Adventures of Nucleic Acids in Molecular Crowding World [Invited]
N. Sugimoto
The seminar of School of Pharmaceutical Sciences, The seminar of College of Chemistry   11 Apr 2019   Peking University
The seminar of School of Pharmaceutical Sciences
The seminar of College of Chemistry
Adventures of Nucleic Acids in Molecular Crowding World [Invited]
N. Sugimoto
The Department Seminar of City University of Hong Kong   25 Mar 2019   
RNAs in Molecular Crowding World [Invited]
N. Sugimoto
The Seminar of Hong Kong RNA Club   25 Mar 2019   
Adventures of Nucleic Acids in Molecular Crowding World [Invited]
N. Sugimoto
The Department Seminar of Sun Yat-sen University   23 Mar 2019   
Elucidation for mechanism of diseases caused by non-canonical structures of DNA and regulation for DNA function
H. Tateishi-Karimata
16 Mar 2019   
Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (48) :Imaging of crowding in cells by using guanine-quadruplex DNA
S.Takahashi, J. Yamamoto, A. Kitamura, M. Kinjo, and N. Sugimoto
16 Mar 2019   
Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (49): Validation of the nearest-neighbor model for self-complementary DNA duplex under molecular crowding
S. Ghosh, S.Takahashi, T. Endoh, H. Tateishi-Karimata, and N. Sugimoto
16 Mar 2019   
Nucleic Acids Chemistry beyond the Watson-Crick Double Helix(50):Phase separation of RNA/peptides in neurodegenerative diseases is promoted by chemical environment changes in cell
H. Tateishi-Karimata, Y. TENG, T.Ohyama, and N. Sugimoto
16 Mar 2019   
Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (52) : Optimization of RNA conformational switch using RNA-capturing microsphere particle (R-CAMP)
T. Endoh and N. Sugimoto,
16 Mar 2019   
Functions of Nucleic Acids under Molecular Crowding Conditions [Invited]
N. Sugimoto
The Lecture of Institute of Biophysics Czech Academy of Sciences   13 Mar 2019   
Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders
Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
Gordon Research Conference(RNA Nanotechnology)   13 Jan 2019   
Molecular Crowding Effect on Functions of Nucleic Acids: [Invited]
N. Sugimoto
The Department seminar, Sungkyunkwan University School of Medicine, The Department seminar, Sungkyunkwan University School of Medicine, Seoul National University, Korea Institute of Science and Technology (KIST)   19 Dec 2018   
THE WORLD OF NON-CANONICAL NUCLEIC ACIDS
N. Sugimoto
The 9th Asian Biological Inorganic Chemistry “AsBIC9”   13 Dec 2018   
Functions of Nucleic Acids with Non-canonical Structures:To B or not to B
N. Sugimoto
KONAN RESEARCH SUMMIT   4 Dec 2018   
Roles of Noncanonical Nucleic Acids on Gene Expressions [Invited]
N. Sugimoto
The 2nd International Symposium on “Functional Nucleic Acids: From Laboratory to Targeted Molecular Therapy"   22 Nov 2018   
Effects of molecular crowding on nearest-neighbor rules for Watson-Crick self-complementary DNA duplexes
S. Ghosh, S. Takahashi, T. Endoh, H. Tateishi-Karimata, S. Hazra, and N, Sugimoto
第45回国際核酸化学シンポジウム   Nov 2018   
Transformation of selective i-motif DNAs into hairpin-like structures induced by a flavonoid compound
S. Takahashi, S. Bhowmik, S. Ghosh, and N. Sugimoto
第45回国際核酸化学シンポジウム   Nov 2018   
Structural Perspectives of the DNA binding properties of Ruthenium Polypyridyl Complexes
K. McQuaid, J. Hall, H. Abell1, S. Takahashi, N. Sugimoto, D. Allan, D. Cardin, J. Brazier, and C. Cardin
第45回国際核酸化学シンポジウム   Nov 2018   
Effect of G-quadruplex stability and structure in the template DNA on transcript mutations in normal and cancer cells
H. Tateishi-Karimata, N. Sugimoto
第45回国際核酸化学シンポジウム   Nov 2018   
Phase separation of repeated RNA with amyloid-like protein in neurodegenerative diseases is promoted by RNA G-quadruplexes
Y. Teng, H. Tateishi-Karimata, and N. Sugimoto
第45回国際核酸化学シンポジウム   Nov 2018   
Investigation for effects of polyethylene glycols on DNA structure and stability using molecular dynamics simulations
T. Ohyama, H.Tateishi-Karimata, S. Tanaka, and N. Sugimoto,
第45回国際核酸化学シンポジウム   Nov 2018   
Effect of noncanonical DNA structures on transcription
N. Sugimoto
The Third A3 Roundtable Meeting on Chemical Probe Research Hub   Nov 2018   
Optimization of junction sequence between two aptamers for constructing signaling aptamer by using RNA library on microspheres
T.Endoh, N.Sugimoto
第45回国際核酸化学シンポジウム   Nov 2018   
“To B or not to B” in Nucleic Acids Chemistry (2)
N. Sugimoto
Advances in Noncanonical Nucleic Acids "ANNA2018"   25 Oct 2018   
Noncanonical world of nucleic acids under molecular crowding
N. Sugimoto
The seminar of the department f Pharmacy University of Naples "Federico II"   21 Oct 2018   
Effects of molecular crowding on nearest-neighbor rules for Watson-Crick self-complementary DNA duplexes
S. Ghosh, S. Takahashi, T. Endoh, H. Tateishi-Karimata, S. Hazra, and N, Sugimoto
第45回国際核酸化学シンポジウム   Oct 2018   
Beyond the Watson-Crick Double Helix:Make New History of Nucleic Acids (6) [Invited]
N. Sugimoto
Asia 3 Roundtable on Nucleic Acids 2018 (A3RONA2018)   4 Sep 2018   
Analysis of structural dynamics of RNA aptamer using high pressure
S. Takahashi, T. Endoh, A. B. Rode, N. Sugimoto
The 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)   Sep 2018   
Noncanonical world of nucleic acids under molecular crowding and high pressure [Invited]
N. Sugimoto
The 10th International Conference on High Pressure Bioscience and Biotechnology (HPBB2018)   Sep 2018   
Nucleic Acids World under Molecular Crowding
N. Sugimoto
The 5th Asian Chemical Biology Conference (ACBC-5)   Aug 2018   
Noncanonical world of nucleic acids under molecular crowding:To B or not to B [Invited]
N. Sugimoto
XXIII International Roundtable of Nucleosides,Nucleotides and Nucleic Acids (IRT2018)   Aug 2018   
Stability and Function of Noncanonical Nucleic Acids [Invited]
N. Sugimoto
The seminar of Institute of Chemical Biology and Fundamental Medicine   19 Jul 2018   
Improved Efficiency of mRNA Sensing System by a Hydrated Ionic Liquid
Hisae Tateishi-Karimata, N. Sugimoto
Gordon Research Conference(Bioanalytical Sensors)   24 Jun 2018   
Nucleic Acids Chemistry Beyond the Watson-Crick Double Helix:“To B or not to B” [Invited]
N. Sugimoto
The Department seminar, Sungkyunkwan University school of medicine   8 Jun 2018   
Nucleic Acids Chemistry Beyond the Watson-Crick Double Helix:“To B or not to B” [Invited]
N. Sugimoto
The Departmental seminar of College of Pharmacy, Ewha Womans University   7 Jun 2018   
Functions of Non-canonical Nucleic Acid [Invited]
N. Sugimoto
International workshop“Trends in Nucleic Acid (TINA) 2018”   14 Apr 2018   
Topological impact of non-canonical DNA structures on the replication
S. Takahashi, N. Sugimoto
ordon Research Conference, DNA Damage, Mutation and Cancer   25 Mar 2018   
Molecular Crowding Effect on Nucleic Acids Chemistry:“To B or not to B”
N. Sugimoto
First International Symposium on Chemistry for Multimolecular Crowding Biosystem   12 Dec 2017   
Effect of noncanonical DNA structures on DNA polymerase
N. Sugimoto
The Second A3 Roundtable Meeting on Asia Chemical Probe Research Hub   25 Nov 2017   
“To B or not to B” in Nucleic Acids Chemistry [Invited]
N. Sugimoto
Advances in Noncanonical Nucleic Acids 2017 “ ANNA2017”   27 Oct 2017   
Transcriptional regulation by DNA structural changes responsive chemical environments in cells during tumor progression [Invited]
H. Tateishi-Kartimata, N. Sugimoto
dvances in Noncanonical Nucleic Acids 2017 “ ANNA2017”   27 Oct 2017   
Non-canonical DNA and RNA in Gene Expressions
N. Sugimoto
Mini-Symposium on Nucleic Acid Chemistry, Pohang University of Science and Technology   13 Oct 2017   
Function of Non-canonical Nucleic Acids
N. Sugimoto
2017 SKKU International Symposium on Molecular Medicine Current Progress in Nucleic Acid Research and Application   12 Oct 2017   
Dynamic Aptamers as New Pharmaceutical Targets
A. B. Rode, T. Endoh, and N. Sugimoto
APTAMERS2017   22 Sep 2017   
Beyond the Watson-Crick Double Helix:Make New History of Nucleic Acids (5)
N. Sugimoto
A3RONA2017   16 Sep 2017   
Nanobioengineering of Non-canonical DNA and RNA [Invited]
N. Sugimoto
The 6th International Conference on DNA Nanotechnology   28 Aug 2017   
Non-canonical Nucleic Acids [Invited]
N. Sugimoto
DNA assembly and nanotechnology   25 Aug 2017   
Regulation of Gene Expressions by Non-canonical DNA and RNA
N. Sugimoto
First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications   17 Aug 2017   
Replication control by topologies of non-canonical DNA structures
S. Takahashi, N. Sugimoto
FIBER国際核酸サミット2017(FISNA 2017)   20 Jul 2017   
The role of non-canonical DNA structures in the replication
S. Takahashi, N. Sugimoto
ordon Research Conference Nucleosides, Nucleotides & Oligonucleotides (NNO)   25 Jun 2017   
Non-canonical World of Nucleic Acids under Molecular Crowding [Invited]
N. Sugimoto
XVIIth Symposium on Chemistry of Nucleic Acid Components "SCNAC2107   5 Jun 2017   
New Targets of Pharmaceutical Drugs: Non-canonical DNA and RNA
N. Sugimoto
6th International Meeting on Quadruplex Nucleic Acids "G4thering   1 Jun 2017   
Nucleic Acids Chemistry beyond the Watson-Crick Double Helix(28): A non-coding tRNA regulates functionaly important G-quadruplex-hairpin conformational equilibria in RNA
A. B. Rode, T. Endoh, N. Sugimoto
日本化学会第97回春季年会   Mar 2017   
Non-canonical Nucleic Acids [Invited]
N. Sugimoto
International workshop“Trends in Nucleic Acid (TINA)”   Mar 2017   
tRNA enhances the oncogene expression through modulation of Hairpin-G-quadruplex conformational equilibrium in RNA
N. Sugimoto
International workshop “Trends in Nucleic Acid (TINA)”   Mar 2017   
Topology of non-canonical DNA structures: the role for replication
N.Sugimoto
Gordon Research Conference RNA Nanotechnology   Jan 2017   

Research Grants & Projects

 
Ribozyme
Stability and Structure Prediction of Nucleic Acids
Interaction of Nucleic Acids with Proteins(Peptides)and Drugs
Characterization of lifemolecules(nucleic acid and protein)
Database construction of lifemolecular interactions
Structural analysis of lifemolecules(nucleic acid, protein)