横井利夫 (Toshio Yokoi) - マイポータル - researchmap

基本情報

所属: 神戸学院大学薬学部薬学科教授

学位: 薬学博士(京都大学)

J-GLOBAL ID: 200901044686529270
researchmap会員ID: 1000111220

研究キーワード

4

研究分野

2

学歴

4

MISC

87

Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells

A Miyazaki, T Yokoi, Y Tachibana, R Enomoto, E Lee, G Bokonyi, G Keri, Y Tsuda, Y Okada

TETRAHEDRON LETTERS 45(33) 6323-6327 2004年8月
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties

Y Fujita, Y Tsuda, TY Li, T Motoyama, M Takahashi, Y Shimizu, T Yokoi, Y Sasaki, A Ambo, A Kita …

JOURNAL OF MEDICINAL CHEMISTRY 47(14) 3591-3599 2004年7月
Oral bioavailability of a new class of mu-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH2)(n)]2(1H)-pyrazinone with central-mediated analgesia

Y Jinsmaa, A Miyazaki, Y Fujita, TY Li, Y Fujisawa, K Shiotani, Y Tsuda, T Yokoi, A Ambo, Y Sasaki …

JOURNAL OF MEDICINAL CHEMISTRY 47(10) 2599-2610 2004年5月
Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98G human glioblastoma cells

K Kosaka, T Yokoi

BIOLOGICAL & PHARMACEUTICAL BULLETIN 26(11) 1620-1622 2003年11月
Carnosic acid, a component of rosemary (Rosmarinus officinalis L.), promotes synthesis of nerve growth factor in T98G human glioblastoma cells

K Kosaka, T Yokoi

BIOLOGICAL & PHARMACEUTICAL BULLETIN 26(11) 1620-1622 2003年11月
Unique High-Affinity Synthetic μ-Opioid Receptor Agonists with central and Systemc-Mediated Analgesia

J. Med. Chem. 46(15) 3201-3209 2003年7月
Unique high-affinity synthetic mu-opioid receptor agonists with central- and systemic-mediated analgesia

Y Okada, Y Tsuda, Y Fujita, T Yokoi, Y Sasaki, A Ambo, R Konishi, M Nagata, S Salvadori, Y Jinsmaa …

JOURNAL OF MEDICINAL CHEMISTRY 46(15) 3201-3209 2003年7月
Structrural studies of '2',6'-Dimetlyl-L-tyrosmine'' endomorphin-2 Analogues: Enhanced Activity as Orientation of the Dmt-Pro Amide Bond

Bioorg. Medo Chem, (Pergamon) (11) 1983-1994 2003年
Structrural studies of '2',6'-Dimetlyl-L-tyrosmine'' endomorphin-2 Analogues: Enhanced Activity as Orientation of the Dmt-Pro Amide Bond

Bioorg. Medo Chem, (Pergamon) (11) 1983-1994 2003年
Immediate deamination from the aminomethyl group attached to 1,2-dihydropyrazin-2-one derivative during catalytic hydrogenation

Tetrahedron Lett. 43, 8137-8139 2002年
Immediate deamination from the aminomethyl group attached to 1,2-dihydropyrazin-2-one derivative during catalytic hydrogenation

Tetrahedron Lett. 43, 8137-8139 2002年
Gastric-Mucous Membrane Protection Activity fo Coptisine Derivatiues

Biol. Pharm. Bull. 24(11), 1277-1281 2001年
Gastric-Mucous Membrane Protection Activity fo Coptisine Derivatiues

Biol. Pharm. Bull. 24(11), 1277-1281 2001年
Synthesis of Stereoisomerie Analogues of Endomorphine-2, H-Try-Pro-Phe-Phe-NH₂, and Examination of their Opioid Receptor・Binding Activities and Solution Conformation (共著)

OKADA Y, FUKUMIZU A, TAKAHASHI M, SHIMIZU Y, TSUDA Y, YOKOI T, BRYANT S D, LAZARUS L H

Biochemical and Biophysical Research Communications 276(1) 7-11 2000年
Analysis of Gastric Mucosus Membrane-Protective Compounds in Coptidis Rhizoma (共著)

Hirano Hiroyuki, Tokuhira Takashi, Yoshioka Yukako, Yoko Toshio, Shingu Tetsuro

Nataral Medicines 54(5) 209-212 2000年
Synthesis of Stereoisomerie Analogues of Endomorphine-2, H-Try-Pro-Phe-Phe-NH₂, and Examination of their Opioid Receptor・Binding Activities and Solution Conformation (共著)

Biochemical and Biophysical Research Communications 276(1) 7-11 2000年
Analysis of Gastric Mucosus membrane-protective compounds in Coptidis rhizoma :

Hirano Hiroyuki, Tokuhira Takashi, Yoshioka Yukako, Yoko Toshio, Shingu Tetsuro

Natural medicines = 生薬學雜誌 54(5) 209-212 2000年
Amino acids and peptides. LVI. Synthesis of pyrazinone ring-containing opioid mimetics and examination of their opioid receptor binding activity

Y Okada, A Fukumizu, M Takahashi, J Yamazaki, T Yokoi, Y Tsuda, SD Bryant, LH Lazarus

TETRAHEDRON 55(50) 14391-14406 1999年12月
Amino acids and peptides. LVI. Synthesis of pyrazinone ring-containing opioid mimetics and examination of their opioid receptor binding activity

Y Okada, A Fukumizu, M Takahashi, J Yamazaki, T Yokoi, Y Tsuda, SD Bryant, LH Lazarus

TETRAHEDRON 55(50) 14391-14406 1999年12月
Synthesis of Pyrazinone Ring-Containing Opioid Mimetics and Examination of Their Opioid Receptor-Binding Activity(共著)

Chem. Pharm. Bull. 47(8) 1193-1195 1999年

もっとみる

所属学協会

7

Works(作品等)

2

生薬成分(フラボノイド)生理活性の探索研究

1999年 - 2000年
Joint Research on Biologically-active constituents(flauonoid)of Crude Drugs

1999年 - 2000年

共同研究・競争的資金等の研究課題

6

タキソール誘導体の構造研究

1995年 - 2001年
Studies on the Structures of Taxol derivatives

1995年 - 2001年
薬用植物の抗かいよう性成分の研究

1996年
Studies on the Anti-ulcer Constituents of medicinal plants

1996年
ピラジノン誘導体の合成とその生物活性

1994年
Synthesis of Pyrazinone Derivatives and Their biological Activities

1994年