MISC

2000年9月

Involvement of the 5-HT2 receptor in hyperthermia induced by p-chloroamphetamine, a serotonin-releasing drug in mice

EUROPEAN JOURNAL OF PHARMACOLOGY
  • Y Sugimoto
  • ,
  • M Ohkura
  • ,
  • K Inoue
  • ,
  • J Yamada

403
3
開始ページ
225
終了ページ
228
記述言語
英語
掲載種別
DOI
10.1016/S0014-2999(00)00585-9
出版者・発行元
ELSEVIER SCIENCE BV

The effects of a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine (PCA), on body temperature were investigated in mice. PCA induced hyperthermia in mice. PCA-induced hyperthermia was inhibited by the 5-HT2A/2B/2C receptor antagonist, 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6A,7,8,9,10,10A-octahydro-indolo[4,3-FG]quinolone maleate (LY53857). The 5-HT2A receptor antagonist, ketanserin, reduced the PCA-induced hyperthermia, while the 5-HT2B/2C receptor antagonist, N-3-pyridinyl-3,5-dihydro-5-methyl-benzo,[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide (SB 206553), enhanced it. LY 53857, ketanserin and SE 206553 did not affect hyperactivity in mice treated with PCA. These results suggest that PCA-induced hyperthermia in mice is mediated by 5-HT2A receptors and is not related to changes in locomotor activity. (C) 2000 Elsevier Science B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S0014-2999(00)00585-9
CiNii Articles
http://ci.nii.ac.jp/naid/80011956489
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10973623
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000089202100007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0014-2999(00)00585-9
  • ISSN : 0014-2999
  • CiNii Articles ID : 80011956489
  • PubMed ID : 10973623
  • Web of Science ID : WOS:000089202100007

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