2021年4月1日
Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA.
Nanotechnology
- 巻
- 32
- 号
- 25
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1088/1361-6528/abef2c
- 出版者・発行元
- IOP PUBLISHING LTD
Detection of cell-free DNA (cfDNA) has an impact on DNA analysis in liquid biopsies. However, current strategies to detect cfDNA have limitations that should be overcome, such as having low sensitivity and requiring much time and a specialized instrument. Thus, non-invasive and rapid detection tools are needed for disease prevention and early-stage treatment. Here we developed a device having a microheater integrated with zinc oxide nanowires (microheater-ZnO-NWs) to detect target single-stranded DNAs (ssDNAs) based on DNA probe hybridization. We confirmed experimentally that our device realizedin-situannealed DNA probes by which we subsequently detected target ssDNAs. We envision that this device can be utilized for fundamental studies related to nanobiodevice-based DNA detection.
- リンク情報
-
- DOI
- https://doi.org/10.1088/1361-6528/abef2c
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33725670
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000635896300001&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103623742&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85103623742&origin=inward
- ID情報
-
- DOI : 10.1088/1361-6528/abef2c
- ISSN : 0957-4484
- eISSN : 1361-6528
- PubMed ID : 33725670
- SCOPUS ID : 85103623742
- Web of Science ID : WOS:000635896300001