2000年
Bullous pemphigoid associated with silicosis
DERMATOLOGY
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- 巻
- 201
- 号
- 3
- 開始ページ
- 265
- 終了ページ
- 267
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- KARGER
Bullous pemphigoid (BP) has never before been reported to associate with silicosis, although there are numerous reports of silicosis accompanied by different autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus, dermatomyositis or rheumatoid arthritis. We report on a 63-year-old Japanese patient with silicosis who developed tensed bullae, erosions and macular pigmentation on the trunk and extremities. Indirect immunofluorescence revealed anti-basement-membrane-zone antibodies; immunoblotting analysis demonstrated that the patient's serum reacted with the 230-kD BP antigen in the epidermal extracts, as well as a recombinant protein of the NC16a domain of 180-kD BP antigen. Clinical symptoms improved after treatment with systemic steroids. To the best of our knowledge, this is the first reported case of BP associated with silicosis. Copyright (C) 2000 S. Karger AG, Basel.
- リンク情報
- ID情報
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- ISSN : 1018-8665
- Web of Science ID : WOS:000165693000017