1999年3月
Mechanisms mediating the vasorelaxing action of eugenol, a pungent oil, on rabbit arterial tissue
JAPANESE JOURNAL OF PHARMACOLOGY
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- 巻
- 79
- 号
- 3
- 開始ページ
- 327
- 終了ページ
- 334
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1254/jjp.79.327
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
The inhibitory actions of eugenol on intracellular Ca2+ concentration ([Ca2+](i)) and the contractions induced by excess extracellular K+ concentration ([K+](o)) in rabbit thoracic aorta were investigated. Applicationn of excess [K+](o) solution (30-90 mM) produced contraction and increased the intensity of the Ca2+ fluorescence signal. Pretreatment with eugenol (greater than or equal to 0.1 mM) reduced both the amplitude of contraction and the intensity of the Ca2+ fluorescence signal, but the contraction was more strongly affected than the [Ca2+](i). Application of eugenol (0.3 mM) to tissue precontracted by 90 mM [K+](o) solution (immediately after the removal of the 90 mM [K+](o) solution) slowed the decay of the [Ca2+](i) signal, but it did not change the rate of relaxation. Carbonyl cyanide m-chlorophenylhydrozone (10 mu M), a mitochondrial metabolic inhibitor, produced a reduction in tension despite a slight increase in [Ca2+](i) when applied to muscle precontracted by 90 mM [K+](o) solution. These results indicate that eugenol relaxes the rabbit thoracic aorta while suppressing the Ca2+-sensitivity and both the uptake and extrusion mechanisms for Ca2+. To judge from the similarities between its actions and those of metabolic inhibitors, eugenol may produce its actions at least partly through metabolic inhibition.
- リンク情報
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- DOI
- https://doi.org/10.1254/jjp.79.327
- CiNii Articles
- http://ci.nii.ac.jp/naid/10008682832
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10230861
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000079381000010&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1254/jjp.79.327
- ISSN : 0021-5198
- CiNii Articles ID : 10008682832
- PubMed ID : 10230861
- Web of Science ID : WOS:000079381000010