MISC

1999年3月

Mechanisms mediating the vasorelaxing action of eugenol, a pungent oil, on rabbit arterial tissue

JAPANESE JOURNAL OF PHARMACOLOGY
  • H Nishijima
  • ,
  • R Uchida
  • ,
  • K Kameyama
  • ,
  • N Kawakami
  • ,
  • T Ohkubo
  • ,
  • K Kitamura

79
3
開始ページ
327
終了ページ
334
記述言語
英語
掲載種別
DOI
10.1254/jjp.79.327
出版者・発行元
JAPANESE PHARMACOLOGICAL SOC

The inhibitory actions of eugenol on intracellular Ca2+ concentration ([Ca2+](i)) and the contractions induced by excess extracellular K+ concentration ([K+](o)) in rabbit thoracic aorta were investigated. Applicationn of excess [K+](o) solution (30-90 mM) produced contraction and increased the intensity of the Ca2+ fluorescence signal. Pretreatment with eugenol (greater than or equal to 0.1 mM) reduced both the amplitude of contraction and the intensity of the Ca2+ fluorescence signal, but the contraction was more strongly affected than the [Ca2+](i). Application of eugenol (0.3 mM) to tissue precontracted by 90 mM [K+](o) solution (immediately after the removal of the 90 mM [K+](o) solution) slowed the decay of the [Ca2+](i) signal, but it did not change the rate of relaxation. Carbonyl cyanide m-chlorophenylhydrozone (10 mu M), a mitochondrial metabolic inhibitor, produced a reduction in tension despite a slight increase in [Ca2+](i) when applied to muscle precontracted by 90 mM [K+](o) solution. These results indicate that eugenol relaxes the rabbit thoracic aorta while suppressing the Ca2+-sensitivity and both the uptake and extrusion mechanisms for Ca2+. To judge from the similarities between its actions and those of metabolic inhibitors, eugenol may produce its actions at least partly through metabolic inhibition.

リンク情報
DOI
https://doi.org/10.1254/jjp.79.327
CiNii Articles
http://ci.nii.ac.jp/naid/10008682832
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10230861
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000079381000010&DestApp=WOS_CPL
ID情報
  • DOI : 10.1254/jjp.79.327
  • ISSN : 0021-5198
  • CiNii Articles ID : 10008682832
  • PubMed ID : 10230861
  • Web of Science ID : WOS:000079381000010

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