永浜政博 (Masahiro Nagahama) - マイポータル

基本情報

所属: 徳島文理大学薬学部薬学科微生物学教授

学位: 薬学修士(徳島文理大学大学院、薬学研究科)
薬学博士(徳島文理大学大学院、薬学研究科)

J-GLOBAL ID: 200901004475178568
researchmap会員ID: 1000115852

研究キーワード

研究分野

ライフサイエンス / 細菌学 /

委員歴

2002年

日本細菌学会, 評議員
2002年

Japanease Society for Bacteriology, Councilor

受賞

論文

Interaction of Clostridium perfringens iota-toxin and lipolysis-stimulated lipoprotein receptor (LSR).

M. Nagahama, M. Takehara, K. Kobayashi

Toxins 10(10) 405-405 2018年10月
Angubindin-1 opens the blood–brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous systems.

S. Zeniya, H. Kuwahara, K. Daizo, A. Watari, M. Kondoh, K. Yoshida-Tanaka, H. Kaburagi, K. Asada, T. Nagata, M. Nagahama …

J. Control Release 283 126-134 2018年8月査読有り
Acid sphingomyelinase promotes cellular internalization of Clostridium perfringens iota-toxin

Masahiro Nagahama, Masaya Takehara, Kazuaki Miyamoto, Kazumi Ishidoh, Keiko Kobayashi

Toxins 10(5) 209 2018年5月1日査読有り
Delta-toxin from Clostridium perfringens perturbs intestinal epithelial barrier function in Caco-2 cell monolayers.

S. Seike, M. Takehara, T. Takagishi, K. Miyamoto, K. Kobayashi, M. Nagahama

Biochim. Biophys. Acta 1860(2) 428-433 2018年2月1日査読有り
Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction

Susanne M. Krug, Tomohiro Hayaishi, Daisuke Iguchi, Akihiro Watari, Azusa Takahashi, Michael Fromm, Masahiro Nagahama, Hiroyuki Takeda, Yoshiaki Okada, Tatsuya Sawasaki …

JOURNAL OF CONTROLLED RELEASE 260 1-11 2017年8月査読有り
Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation.

T. Takagishi, M. Takehara, S. Seike, K. Miyamoto, K. Kobayashi, M. Nagahama

Sci. Rep. 7(1) 5217 2017年7月査読有り
Peptidoglycan accelerates granulopoiesis through a TLR2-and MyD88-dependent pathway

Masaya Takehara, Soshi Seike, Teruhisa Takagishi, Keiko Kobayashi, Masahiro Nagahama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 487(2) 419-425 2017年5月査読有り
Cellular Uptake of Clostridium botulinum C2 Toxin Requires Acid Sphingomyelinase Activity

Masahiro Nagahama, Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi

INFECTION AND IMMUNITY 85(4) e00966-16 2017年4月査読有り
Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death

Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1858(12) 3150-3156 2016年12月査読有り
Oligomer formation of Clostridium perfringens epsilon-toxin is induced by activation of neutral sphingomyelinase

Teruhisa Takagishi, Masataka Oda, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1858(11) 2681-2688 2016年11月査読有り
Clostridium perfringens α-toxin impairs innate immunity via inhibition of neutrophil differentiation.

M. Takehara, T. Takagishi, S. Seike, K. Ohtani, K. Kobayashi, K. Miyamoto, T. Shimizu, M. Nagahama

Sci. Rep. 6 2819 2016年6月査読有り
Clostridium perfringens α-toxin impairs lipid raft integrity in neutrophils.

M. Takehara, T. Takagishi, S. Seike, K. Oishi, Y. Fujihara, K. Miyamoto, K. Kobayashi, M. Nagahama

Biol. Pharm. Bull. 39(10) 1694-1700 2016年査読有り
Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis

Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama

PLOS ONE 11(1) e0147957 2016年1月査読有り
Role of P2X(7) receptor in Clostridium perfringens beta-toxin-mediated cellular injury

Masahiro Nagahama, Soshi Seike, Hidenori Shirai, Teruhisa Takagishi, Keiko Kobayashi, Masaya Takehara, Jun Sakurai

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850(11) 2159-2167 2015年11月査読有り
Identification of the replication region in pBCNF5603, a bacteriocin-encoding plasmid, in the enterotoxigenic Clostridium perfringens strain F5603

Kazuaki Miyamoto, Soshi Seike, Teruhisa Takagishi, Kensuke Okui, Masataka Oda, Masaya Takehara, Masahiro Nagahama

BMC MICROBIOLOGY 15 118 2015年6月査読有り
Clostridium perfringens TpeL induces formation of stress fibers via activation of RhoA-ROCK signaling pathway

Masahiro Nagahama, Akiko Ohkubo, Yoshihito Kinouchi, Keiko Kobayashi, Kazuaki Miyamoto, Masaya Takehara, Jun Sakurai

Biological and Pharmaceutical Bulletin 38(5) 732-739 2015年5月1日査読有り
Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane

Teruhisa Takagishi, Masataka Oda, Michiko Kabura, Mie Kurosawa, Kaori Tominaga, Shiori Urano, Yoshibumi Ueda, Keiko Kobayashi, Toshihide Kobayashi, Jun Sakurai …

PLOS ONE 10(4) e0120497 2015年4月査読有り
Recent Insights into Clostridium perfringens Beta-Toxin

Masahiro Nagahama, Sadayuki Ochi, Masataka Oda, Kazuaki Miyamoto, Masaya Takehara, Keiko Kobayashi

TOXINS 7(2) 396-406 2015年2月査読有り
Vizantin Inhibits Endotoxin-Mediated Immune Responses via the TLR 4/MD-2 Complex

Masataka Oda, Hirofumi Yamamoto, Masahiro Shibutani, Mayo Nakano, Kenta Yabiku, Takafumi Tarui, Naoya Kameyama, Daiki Shirakawa, Sumiyo Obayashi, Naoyuki Watanabe …

JOURNAL OF IMMUNOLOGY 193(9) 4507-4514 2014年11月査読有り
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis

Masataka Oda, Hiroshi Imagawa, Ryoko Kato, Kenta Yabiku, Tomomi Yoshikawa, Takayuki Takemoto, Hironobu Takahashi, Hirofumi Yamamoto, Mugio Nishizawa, Jun Sakurai …

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 29(3) 303-310 2014年6月査読有り

もっとみる

MISC

Cellular entry of Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin.

M. Takehara, T. Takagishi, S. Seike, M. Oda, Y. Sakaguchi, J. Hisatsune, S. Ochi, K. Kobayashi, M. Nagahama

Toxins. 9(8) 247 2017年8月査読有り
Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin

Masataka Oda, Yutaka Terao, Jun Sakurai, Masahiro Nagahama

TOXINS 7(12) 5268-5275 2015年12月査読有り
Enteric Toxins of Clostridium perfringens: Beta Toxin, TpeL, Epsilon Toxin and Iota Toxin

Masahiro Nagahama, Masataka Oda, Hideaki Tsuge, Keiko Kobayashi

Molecular Medical Microbiology: Second Edition 2-3 997-1013 2014年11月26日査読有り
Vaccines against clostridium perfringens alpha-toxin

Masahiro Nagahama

Current Pharmaceutical Biotechnology 14(10) 913-917 2013年査読有り
Role of tyrosine kinase A receptor (TrkA) on pathogenicity of Clostridium perfringens alpha-toxin.

M. Oda, M. Nagahama, K. Kobayashi, J. Sakurai

Protein Phosphorylation in Human Health. InTech 343-356 2012年9月
Glycosylating toxin of Clostridium perfringens.

M. Nagahama, M. Oda, K. Kobayash.i

Glycosylation. InTech 153-172 2012年6月
Role of phospholipid metabolism and G protein in the action induced by Clostridium perfringens alpha-toxin.

M. Nagahama, M. Oda, K. Kobayashi, J. Sakurai

J. Glycomics Lipidomics S3 1-5 2012年3月査読有り
Cellular vacuolation induced by Clostridium perfringens epsilon-toxin

Masahiro Nagahama, Yukari Itohayashi, Hideki Hara, Masahiro Higashihara, Yusuke Fukatani, Teruhisa Takagishi, Masataka Oda, Keiko Kobayashi, Ichiro Nakagawa, Jun Sakurai

FEBS JOURNAL 278(18) 3395-3407 2011年9月査読有り
Induction of neurite-outgrowth in PC12 cells by alpha-toxin from Clostridium perfringens

Masataka Oda, Yuki Saito, Yuka Morimune, Masahiro Nagahama, Jun Sakurai

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 411(2) 241-246 2011年7月査読有り
Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens L-toxin

Hideaki Tsuge, Masahiro Nagahama, Masataka Oda, Shinobu Iwamoto, Hiroko Utsunomiya, Victor E. Marquez, Nobuhiko Katunuma, Mugio Nishizawa, Jun Sakurai

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(21) 7399-7404 2008年5月
Role of tyrosine-57 and -65 in membrane-damaging and sphingomyelinase activities of Clostridium perfringens alpha-toxin

M Nagahama, A Otsuka, J Sakurai

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1762(1) 110-114 2006年1月
Role of tyrosine-57 and -65 in membrane-damaging and shingomyelinase activities of Clostridium perfringens alpha-toxin.

Biochimica et Biophysica Acta 1762(1), 110-114 2005年
Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells

M Nagahama, S Hayashi, S Morimitsu, J Sakurai

JOURNAL OF BIOLOGICAL CHEMISTRY 278(38) 36934-36941 2003年9月
Mechanism of action of Clostridium perfringens beta-toxin.

J. Sakurai, M. Nagahama

Rec. Res. Develop. Infect. Immun. 1 433-449 2003年
Mechanism of action of Clostridium perfringens beta-toxin.(jointly worked)

Recent research developments in Infection & Immunity 1, 433-449 2003年
Clostridium perfringens α-toxin induces rabbit neutrophil adhesion. (共著)

Microbiology 148, 237-245 2002年
Role of tryptophan-1 in hemolytic and phospholipase C activities of ┣DBClostridium(/)-┫DB ┣DBperfringens(/)-┫DB alpha-toxin.(共著)

Microbiol. Immunol. 44(7) 585-589 2000年
Mechanism of membrane damage by ┣DBClostridium(/)-┫DB ┣DBperfringens(/)-┫DB alpha-toxin. (共著)

Microbiol. Immunol. 42(8) 533-538 1998年
Assembly of ┣DBClostridium(/)-┫DB ┣DBperfringens(/)-┫DB epsilon-toxin on MDCK cell membrane. (共著)

Journal of Natural Toxins 7(3) 291-302 1998年
Major toxins of Clostridium perfringens

J Sakurai, M Nagahama, S Ochi

JOURNAL OF TOXICOLOGY-TOXIN REVIEWS 16(4) 195-214 1997年

もっとみる

書籍等出版物

Gram Positive Pathogens 3rd Edition

M. Nagahama, M. Takehara, J.I. Rood (担当:分担執筆, 範囲:Histotoxic clostridial infections.)

ASM Press 2019年
スタンダード薬学シリーズ２生物系薬学 III. 生体防御と微生物

永浜政博 (担当:分担執筆, 範囲:代表的な細菌毒素について説明できる)

東京化学同人 2016年7月 (ISBN: 9784807917105)
Encyclopedia of Food and Health 1st Edition

K. Miyamoto, M. Nagahama (担当:分担執筆, 範囲:Clostridium: Food poisoning by Clostridium perfringens)

Academic Press 2015年9月 (ISBN: 9780123849472)
Molecular Medical Microbiology, 2nd

M. Nagahama, M. Oda, K. Kobayashi, H. Tsuge (担当:分担執筆, 範囲:Clostridium perfringens: Beta-toxin, tpeL, epsilon- toxin, and iota-toxin)

Academic Press 2014年10月 (ISBN: 9780123971692)
微生物胞子―制御と対策―

櫻井純, 永浜政博, 小田真隆 (担当:分担執筆, 範囲:芽胞形成細菌の毒素：嫌気性細菌)

サイエンスフォーラム 2011年4月 (ISBN: 9784905098027)
細菌毒素ハンドブック (共著)

サイエンスフォーラム 2002年
イラストレイテッド微生物学第2版(共著)

南山堂 2000年
イラストレイテッド微生物学(共著)

南山堂 1993年

永浜政博

基本情報

研究キーワード

研究分野

委員歴

受賞

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー