原口浩一 (Koichi Haraguchi) - マイポータル - researchmap

基本情報

所属: 第一薬科大学薬学部薬学教育支援センター教授

学位: 薬学博士(九州大学)

J-GLOBAL ID: 200901038076213513
researchmap会員ID: 1000117555

研究キーワード

2

研究分野

1

ライフサイエンス / 薬系衛生、生物化学 /

経歴

8

1996年 - 2001年

第一薬科大学助教授
1996年 - 2001年

Daiichi College of Pharmaceutical Sciences, Assistant Professor
2001年

第一薬科大学教授
2001年

- Daiichi College of Pharmaceutical Sciences, Professor
1990年 - 1996年

第一薬科大学講師
1990年 - 1996年

Daiichi College of Pharmaceutical Sciences, Lecturer
1979年 - 1990年

第一薬科大学助手
1979年 - 1990年

Daiichi College of Pharmaceutical Sciences, Research Assistant.

学歴

4

論文

26

Levels and profiles of long-chain perfluoroalkyl carboxylic acids in Pacific cod from 14 sites in the North Pacific Ocean.

Fujii Y, Tuda H, Kato Y, Kimura O, Endo T, Harada KH, Koizumi A, Haraguchi K

Environmental Pollution 247 312-318 2019年査読有り
Tissue-specific bioaccumulation of long-chain perfluorinated carboxylic acids and halogenated methylbipyrroles in Dall's porpoises (Phocoenoides dalli) and harbor porpoises (Phocoena phocoena) stranded in northern Japan

Yukiko Fujii, Yoshihisa Kato, Kentarou Sakamoto, Takashi Matsuishi, Harada H. Kouji, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi

Science of the Total Environment 616-617 554-563 2018年3月1日査読有り
Comparison of radiocesium and stable isotope ratios of carbon and nitrogen among three stocks of Pacific cod (Gadus macrocephalus) around Hokkaido, Japan

Tsugiya Nakamura, Toshiyasu Tanaka, Osamu Kimura, Yukiko Fujii, Koichi Haraguchi, Tetsuya Endo

Marine Pollution Bulletin 127 39-44 2018年2月1日査読有り
Different profiles of naturally produced and anthropogenic organohalogens in the livers of cetaceans from the Sea of Japan and the North Pacific Ocean.

Fujii Y, Kato Y, Kozai M, Matsuishi T, Harada KH, Koizumi A, Kimura O, Endo Haraguchi K

Marine Pollution Bulletin 127 39-44 2018年査読有り
Contamination trends and factors affecting the transfer of hexabromocyclododecane diastereomers, tetrabromobisphenol A, and 2,4,6-tribromophenol to breast milk in Japan.

Fujii Y, Kato Y, Masuda N, Harada KH, Koizumi A, Haraguchi K

Environmental Pollution 237 936-943 2018年査読有り
Growth-related changes in non-essential and essential metals in the liver of star-spotted smooth-hounds (dogfish) Mustelus manazo from the northern region of Japan

Tetsuya Endo, Osamu Kimura, Masaru Terasaki, Yukiko Fujii, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato

MARINE ENVIRONMENTAL RESEARCH 131 156-161 2017年10月査読有り
Long-term trends in dietary intake of perfluoroalkyl carboxylic acids in relation to their serum concentration in two regions in Japan from 1979 to 2011

Yukiko Fujii, Kouji H. Harada, Koichi Haraguchi, Akio Koizumi

CHEMOSPHERE 176 165-174 2017年6月査読有り
2,2',3,4,4',5,6'-七塩素化ビフェニル(CB182)のラット,モルモットおよびヒト肝ミクロゾームによる代謝

太田千穂, 藤井由希子, 原口浩一, 加藤善久, 木村治, 遠藤哲也, 古賀信幸

福岡医学雑誌 106 176-183 2017年査読有り
Bisphenol AF as an inducer of estrogen receptorβ (ERβ): Evidence for anti-estrogenic effects at higher concentrations in human breast cancer cells.

Okazaki H, Takeda S, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Ishii H, Kohro-Ikeda E, Haraguchi K, Watanabe K …

Biological & Pharmaceutical Bulletin 40(11) 1909-1916 2017年査読有り
Possible mechanism for the polychlorinated biphenyl induced liver-selective accumulation of thyroxine in rats. Kato Y, Fujii A, Haraguchi K, Fujii Y, Atobe K, Tetsuya, Endo T, Kimura O, Koga N, Ohta C, Yamada S, Degawa M.

The Journal of Toxicological Sciences 42(663) 669 2017年査読有り
Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples

Koichi Haraguchi, Yoshiko Ito, Masae Takagi, Yukiko Fujii, Kouji H. Harada, Akio Koizumi

ENVIRONMENT INTERNATIONAL 97 155-162 2016年12月査読有り
Relationship between mercury, organochlorine compounds and stable isotope ratios of carbon and nitrogen in yellowfin tuna (Thunnus albacares) taken from different regions of the Pacific and Indian Oceans

Tetsuya Endo, Osamu Kimura, Yukiko Fujii, Koichi Haraguchi

ECOLOGICAL INDICATORS 69 340-347 2016年10月査読有り
Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers

Osamu Kimura, Yukiko Fujii, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo

JOURNAL OF PHARMACY AND PHARMACOLOGY 68(7) 883-889 2016年7月査読有り
Metal concentrations in the liver and stable isotope ratios of carbon and nitrogen in the muscle of silvertip shark (Carcharhinus albimarginatus) culled off Ishigaki island, Japan: Changes with growth.

Endo T, Kimura O, Ohta C, Koga N, Kato Y, Fujii Y, Haraguchi K

PLoS One 11 e0147797 2016年査読有り
Mercury, cadmium, zinc and copper concentrations and stable isotope ratios of carbon and nitrogen in tiger sharks (Galeocerdo cuvier) culled off Ishigaki Island, Japan

Tetsuya Endo, Osamu Kimura, Hideki Ogasawara, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Koichi Haraguchi

ECOLOGICAL INDICATORS 55 86-93 2015年8月査読有り
Long-chain perfluoroalkyl carboxylic acids in Pacific cods from coastal areas in northern Japan: A major source of human dietary exposure

Yukiko Fujii, Tsukasa Sakurada, Kouji H. Harada, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi

ENVIRONMENTAL POLLUTION 199 35-41 2015年4月査読有り
2,2’,3,4,5,5’-七塩素化ビフェニル(CB180)の動物肝ミクロゾームによる代謝

太田千穂, 原口浩一, 加藤善久, 遠藤哲也, 木村治, 古賀信幸

福岡医学雑誌 106 176-183 2015年査読有り
Relationships among mercury concentration and stable isotope ratios of carbon and nitrogen in the scalp hair of residents from seven countries: effects of marine fish and C4 plants consumption.

Endo T, Hayasaka M, Ogasawara H, Kimura O, Kotaki Y, Haraguchi K

PLoS One 10 e0128149 2015年査読有り
Distribution and excretion of 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs.

Ohta C, Haraguchi K, Kato Y, Endo T, Kimura O, Koga N

Chemosphere 118 5-11 2015年1月査読有り
Uptake of Aristolochic Acid I into Caco-2 Cells by Monocarboxylic Acid Transporters

Osamu Kimura, Koichi Haraguchi, Chiho Ohta, Nobuyuki Koga, Yoshihisa Kato, Tetsuya Endo

BIOLOGICAL & PHARMACEUTICAL BULLETIN 37(9) 1475-1479 2014年9月査読有り

もっとみる

MISC

32

Metabolite of 2, 2', 4', 5-tetrabromobiphenyl, 3-methylsufony1-2, 2', 4'. 5-tetrabromobiphenyl, a potent inducer of CYP2B1/2 in rat

Xenobiotica 32, 289-393 2002年
Human health Significance of organo chlorine and mercury contaminants in Japanese whale meat

Toxicol. Environ. Health 65, 1211-1235 2002年
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims

G. M. Troisi, K. Haraguchi, D. S. Kaydoo, M. Nyman, A. Aguilar, A. Borrell, U. Siebert, C. F. Mason

Journal of Toxicology and Environmental Health - Part A 62(1) 1-8 2001年1月12日
The changes of PCBs and PCDFs as well as symptoms in Yusho patients for 30 years.

┣DBFukuoka Acta Medica(/)-┫DB,92,167-176(2001) 92(5) 167-176 2001年
Species differences in the in vitro metabolism of 2, 4, 5, 2', 3', 4'-hexachlorobiphenyl.

┣DBFukuoka Acta Medica(/)-┫DB,92,149-157(2001) 92(5) 149-157 2001年
Reduction of serum thyroxine concentrations by methylsulfonyl metabolites of tetra-, penta- and hexachlorinated biphenyls in male sprague-dawley rats

Y Kato, K Haraguchi, T Shibahara, S Yumoto, Y Masuda, R Kimura

CHEMOSPHERE 40(9-11) 1233-1240 2000年5月
Contamination survey of heavy metals and organochlorine compounds in cetacean products purchased in Japan.

Koichi HARAGUCHI, Tetsuya ENDO, Masakatsu SAKATA, Yoshito MASUDA, Mark SIMMONDS

┣DBJ. Food Hyg. Soc. Japan(/)-┫DB,41,287-296(2000) 41(4) 287-296 2000年
Tissue distribution of methylsulfonyl metabolites derived from 2,2 ',4,5,5 '-penta- and 2,2 ',3,4 ',5 ',6-hexachlorobiphenyls in rats

K Haraguchi, Y Kato, R Kimura, Y Masuda

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 37(1) 135-142 1999年7月
Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra-and pentachlorinated biphenyl in male Sprague-Dawley rats.

Toxicol. Sci. 48(1) 51-54 1999年
Inhibition of cell-cell communication by methylsulfonyl metabolites of polychlorinated biphenyl congeners in rat liver epithelial IAR 20 cells

Y Kato, K Kenne, K Haraguchi, Y Masuda, R Kimura, L Warngard

ARCHIVES OF TOXICOLOGY 72(3) 178-182 1998年2月
Hydroxylation and methylthiolation of mono-ortho-substituted polychlorinated biphenyls in rats : Identification of metabolites with tissue affinity. 共著

Chemical Research in Toxicology 11(12) 1508-1515 1998年
Methyl sulphone metabolites of polychlorinated biphenyls(PCBs)in Cetaceans from the Irish and the Aegean Seas. 共著

Archives of Environmental Contamination and Toxicology 35(1) 121-128 1998年
Reduction of thyroid hormone levels by methylsulfonyl metabolites of polychlorinated biphenyl congeners in rats. 共著

Archives of Toxicology 72(8) 541-544 1998年
Metabolism of 3,3',4,4'-tetrachlorobiphenyl via sulphur-containing pathway in rat: liver-specific retention of methylsulphonyl metabolite

K Haraguchi, Y Kato, Y Masuda, R Kimura

XENOBIOTICA 27(8) 831-842 1997年8月
Comparative study on formation of hydroxy and sulfur-containing metabolites from different chlorinated biphenyls with 2,5-substitution in rats

K Haraguchi, Y Kato, R Kimura, Y Masuda

DRUG METABOLISM AND DISPOSITION 25(7) 845-852 1997年7月
Structure-dependent induction of CYP2B1/2 by 3-methylsulfonyl metabolites of polychlorinated biphenyl congeners in rats

Y Kato, K Haraguchi, K Tomiyasu, H Saito, M Isogai, Y Masuda, R Kimura

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 3(2) 137-144 1997年6月
Tissue distribution of methylsulfonyl metabolites derived from Kanechlor 400 in mice

88(5) 157-161 1997年
CHARACTERIZATION OF HEPATIC-MICROSOMAL CYTOCHROME-P-450 FROM RATS TREATED WITH METHYLSULFONYL METABOLITES OF POLYCHLORINATED BIPHENYL CONGENERS

Y KATO, K HARAGUCHI, M KAWASHIMA, S YAMADA, M ISOGAI, Y MASUDA, R KIMURA

CHEMICO-BIOLOGICAL INTERACTIONS 95(3) 269-278 1995年4月
INDUCTION OF HEPATIC-MICROSOMAL DRUG-METABOLIZING-ENZYMES BY METHYLSULFONYL METABOLITES OF POLYCHLORINATED BIPHENYL CONGENERS IN RATS

Y KATO, K HARAGUCHI, M KAWASHIMA, S YAMADA, Y MASUDA, R KIMURA

CHEMICO-BIOLOGICAL INTERACTIONS 95(3) 257-268 1995年4月
Change of PCDF and PCB concentrations in the blood of Yucheng and Yusho patients for 25 years

Fukuoka Acta Medica 86(5) 178-183 1995年

もっとみる

担当経験のある科目(授業)

2

所属学協会

2

共同研究・競争的資金等の研究課題

9

東南アジアの海洋生物が産出する抗菌性臭素化ビフェノール類の分布と特性

日本学術振興会科研費基盤研究B 2013年 - 2015年

原口浩一
生体試料バンクを有効活用した食品および母乳の継続的モニタリング

厚生労働省科研費 2012年 - 2014年

小泉昭夫
天然由来脂溶性ハロゲン化合物のヒト残留実態および代謝活性化による影響評価

日本学術振興会科研費基盤研究B 2012年 - 2014年

原口浩一
太平洋島嶼における天然有機ハロゲン化合物の生成機構および生物濃縮に関する研究

日本学術振興会科研費基盤研究B 2008年 - 2010年

原口浩一
海綿由来の抗菌活性物質の探索および感染症治療薬リード化合物の創製

日本学術振興会科研費基盤研究B 2007年 - 2009年

原口浩一
オセアニア海域における天然由来脂溶性ハロゲン有機化合物の起源調査

日本学術振興会科研費基盤研究B 2005年 - 2007年

原口浩一
Comtamination survey of marine products

1999年
Study on Environmental Pollution of Toxic Chemicals

1991年 - 1994年
Study on Metabolism and Toxicity of Polyhalogeneted Biphenyl and related compound.

1994年