2002年12月
Protective effect of diltiazem, a L-type calcium channel antagonist, on bisphenol A-enhanced hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion in rat striatum
NEUROSCIENCE LETTERS
- ,
- ,
- 巻
- 334
- 号
- 3
- 開始ページ
- 211
- 終了ページ
- 213
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0304-3940(02)01110-2
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
The present study examined whether bisphenol A enhanced 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (.OH) generation in rat striatum using microdialysis technique. These elevations were detected by increases in non-enzymatic formation of 2,3-dihydroxybenzoic acid levels. Bisphenol A significantly enhanced MPP+-induced .OH generation. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on bisphenol A (10 muM) and MPP+ (5 mM)induced .OH generation were studied. Ddiltiazem (100 muM) significantly suppressed bisphenol A and MPP+-induced .OH generation. The results indicate bisphenol A augmented .OH generation, and diltiazem may have preventive effect on bisphenol A and MPP+-induced .OH generation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0304-3940(02)01110-2
- ISSN : 0304-3940
- PubMed ID : 12453631
- Web of Science ID : WOS:000179763300016