論文

査読有り
2002年12月

Protective effect of diltiazem, a L-type calcium channel antagonist, on bisphenol A-enhanced hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion in rat striatum

NEUROSCIENCE LETTERS
  • T Obata
  • ,
  • H Kinemuchi
  • ,
  • M Aomine

334
3
開始ページ
211
終了ページ
213
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0304-3940(02)01110-2
出版者・発行元
ELSEVIER SCI IRELAND LTD

The present study examined whether bisphenol A enhanced 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (.OH) generation in rat striatum using microdialysis technique. These elevations were detected by increases in non-enzymatic formation of 2,3-dihydroxybenzoic acid levels. Bisphenol A significantly enhanced MPP+-induced .OH generation. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on bisphenol A (10 muM) and MPP+ (5 mM)induced .OH generation were studied. Ddiltiazem (100 muM) significantly suppressed bisphenol A and MPP+-induced .OH generation. The results indicate bisphenol A augmented .OH generation, and diltiazem may have preventive effect on bisphenol A and MPP+-induced .OH generation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S0304-3940(02)01110-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12453631
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000179763300016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0304-3940(02)01110-2
  • ISSN : 0304-3940
  • PubMed ID : 12453631
  • Web of Science ID : WOS:000179763300016

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