2001年6月
Phenytoin promotes Th2 type immune response in mice
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
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- 巻
- 124
- 号
- 3
- 開始ページ
- 406
- 終了ページ
- 413
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1046/j.1365-2249.2001.01491.x
- 出版者・発行元
- BLACKWELL SCIENCE LTD
The effects of chronic administration of phenytoin, a common anticonvulsive drug, on immune responses were studied in mice. Anti-keyhole limpet haemocyanin (KLH) IgE antibody response after KLH-immunization was enhanced in phenytoin-treated mice. Proliferative responses of spleen cells induced with KLH, concanavalin A (ConA), lipopolysaccharide and anti-CD3 antibody were reduced in phenytoin-treated mice. Accessory function of spleen adherent cells on ConA-induced T cell proliferative response was reduced in phenytoin-treated mice. KLH-induced IL-4 production of spleen cells was enhanced, while IFN-gamma production was reduced in phenytoin-treated mice. In addition, production of IL-1 alpha, but not IL-6 and IL-12 by spleen adherent cells from phenytoin-treated mice was reduced. Natural killer cell activity was reduced in phenytoin-treated mice. These results suggest that phenytoin treatment preferentially induces a Th2 type response. We also observed that plasma ACTH and corticosterone levels were increased in phenytoin-treated mice, and speculated that phenytoin might act directly and indirectly, through HPA axis activation, on the immune system to modulate Th1/Th2 balance.
- リンク情報
- ID情報
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- DOI : 10.1046/j.1365-2249.2001.01491.x
- ISSN : 0009-9104
- Web of Science ID : WOS:000169880900010