論文

査読有り 国際誌
2009年11月

Positive Effect of Alendronate on Subchondral Bone Healing and Subsequent Cartilage Repair in a Rabbit Osteochondral Defect Model

AMERICAN JOURNAL OF SPORTS MEDICINE
  • Kohei Nishitani
  • ,
  • Takaaki Shirai
  • ,
  • Masahiko Kobayashi
  • ,
  • Hiroshi Kuroki
  • ,
  • Yoshiaki Azuma
  • ,
  • Yasuaki Nakagawa
  • ,
  • Takashi Nakamura

37
開始ページ
139S
終了ページ
147S
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0363546509350984
出版者・発行元
SAGE PUBLICATIONS INC

Background: Cartilage and subchondral bone have recently been considered an osteochondral unit. The treatment of osteochondral lesions is still challenging, but better subchondral bone repair may result in higher quality repaired cartilage.
Hypotheses: Alendronate accelerates bone formation in osteochondral defects and affects the quality of the repaired cartilage.
Study Design: Controlled laboratory study.
Methods: Osteochondral defects were made on the left trochleas of 50 rabbits, which were assigned to 1 of 3 groups: control, ALN (weekly subcutaneous injection of 0.14 mg/mL alendronate), and ALN-S (alendronate injection in the first 8 weeks only). They were evaluated at 4, 8, 24, and 52 weeks. Bone repair was evaluated with microcomputed tomography and histologic evaluation. Cartilage repair was evaluated with ultrasound and histologic analyses.
Results: At 4 weeks, the defects were filled, and cartilage-like repair tissue was observed in the ALN group, whereas the defects were incompletely filled in the control group. Alendronate treatment enhanced early bone formation and mineralization in the osteochondral defect for the first 8 weeks. The continuous injection of alendronate for 24 weeks resulted in delayed bone remodeling, but the rabbits in the ALN-S group showed good integrity of the subchondral bone plate, without delayed remodeling. At 52 weeks, the ALN-S group had a columnar arrangement of chondrocytes that had less fibrillation and looked superior to those in the ALN and control groups. Ultrasound analysis showed better quality of repaired cartilage of the ALN and ALN-S group than the control group.
Conclusion: Alendronate accelerated bone formation without inhibiting its mineralization but thereafter inhibited bone remodeling in an osteochondral defect. The withdrawal of alendronate at 8 weeks avoided the delayed remodeling and showed better subchondral bone repair. At 52 weeks, better subchondral bone repair resulted in better cartilage quality.

リンク情報
DOI
https://doi.org/10.1177/0363546509350984
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19934441
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000271964400019&DestApp=WOS_CPL
ID情報
  • DOI : 10.1177/0363546509350984
  • ISSN : 0363-5465
  • PubMed ID : 19934441
  • Web of Science ID : WOS:000271964400019

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