2015年7月
Intermittent application of hypergravity by centrifugation attenuates disruption of rat gait induced by 2 weeks of simulated microgravity
BEHAVIOURAL BRAIN RESEARCH
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- 巻
- 287
- 号
- 開始ページ
- 276
- 終了ページ
- 284
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbr.2015.03.030
- 出版者・発行元
- ELSEVIER SCIENCE BV
The effects of intermittent hypergravity on gait alterations and hindlimb muscle atrophy in rats induced by 2 weeks of simulated microgravity were investigated. Rats were submitted to hindlimb unloading for 2 weeks (unloading period), followed by 2 weeks of reloading (recovery period). During the unloading period, animals were subjected to the following treatments: (1) free in cages (Control): (2) continuous unloading (UL); (3) released from unloading for 1 hour per day (UL + 1G); (4) hypergravity for 1 h per day using a centrifuge for small animals (UL + 2G). The relative weights of muscles to the whole body weight and kinematics properties of hindlimbs during gait were evaluated. UL rats walked with their hindlimbs overextended, and the oscillation of their limb motion had become narrowed and forward-shifted after the unloading period, and this persisted for at least 2 weeks after the termination of unloading. However, these locomotor alterations were attenuated in rats subjected to UL + 2G centrifugation despite minor systematic changes in muscle recovery. These findings indicate hypergravity application could counteract the adverse effects of simulated or actual microgravity environments. (C) 2015 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bbr.2015.03.030
- ISSN : 0166-4328
- eISSN : 1872-7549
- PubMed ID : 25819803
- Web of Science ID : WOS:000355037700035