論文

査読有り 最終著者 国際誌
2020年4月29日

Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies.

International journal of molecular sciences
  • Akira Ito
  • ,
  • Naoko Kubo
  • ,
  • Nan Liang
  • ,
  • Tomoki Aoyama
  • ,
  • Hiroshi Kuroki

21
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms21093135

Neurological diseases severely affect the quality of life of patients. Although existing treatments including rehabilitative therapy aim to facilitate the recovery of motor function, achieving complete recovery remains a challenge. In recent years, regenerative therapy has been considered as a potential candidate that could yield complete functional recovery. However, to achieve desirable results, integration of transplanted cells into neural networks and generation of appropriate microenvironments are essential. Furthermore, considering the nascent state of research in this area, we must understand certain aspects about regenerative therapy, including specific effects, nature of interaction when administered in combination with rehabilitative therapy (regenerative rehabilitation), and optimal conditions. Herein, we review the current status of research in the field of regenerative therapy, discuss the findings that could hold the key to resolving the challenges associated with regenerative rehabilitation, and outline the challenges to be addressed with future studies. The current state of research emphasizes the importance of determining the independent effect of regenerative and rehabilitative therapies before exploring their combined effects. Furthermore, the current review highlights the progression in the treatment perspective from a state of compensation of lost function to that of a possibility of complete functional recovery.

リンク情報
DOI
https://doi.org/10.3390/ijms21093135
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32365542
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247676
ID情報
  • DOI : 10.3390/ijms21093135
  • PubMed ID : 32365542
  • PubMed Central 記事ID : PMC7247676

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