論文

査読有り
2020年3月1日

Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women

The Journal of Nutrition
  • Akane Kojima
  • ,
  • Satoyo Ikehara
  • ,
  • Kuniyasu Kamiya
  • ,
  • Etsuko Kajita
  • ,
  • Yuho Sato
  • ,
  • Katsuyasu Kouda
  • ,
  • Junko Tamaki
  • ,
  • Sadanobu Kagamimori
  • ,
  • Masayuki Iki

150
3
開始ページ
599
終了ページ
605
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jn/nxz292
出版者・発行元
Oxford University Press (OUP)

<title>ABSTRACT</title>
<sec>
<title>Background</title>
The direct association between intake of Japanese fermented soybeans, namely natto, and bone mineral density (BMD) is known. However, the association with osteoporotic fractures has not been studied.


</sec>
<sec>
<title>Objective</title>
This study aimed to investigate whether habitual natto intake is associated with a risk of osteoporotic fractures.


</sec>
<sec>
<title>Methods</title>
This prospective cohort study included 1417 postmenopausal Japanese women who were enrolled in the Japanese Population-Based Osteoporosis cohort study in 1996, 1999, 2002, and 2006 and were aged ≥45 y at baseline. The intake of natto, tofu, and other soybean products was surveyed with use of a FFQ at baseline. Fractures were ascertained in follow-up surveys conducted in 1999, 2002, 2006, and 2011/2012. Osteoporotic fracture was the primary outcome and was defined as a clinical fracture occurring without strong external force, diagnosed with radiographs by a medical doctor. HRs with 95% CIs were estimated with Cox proportional hazard models.


</sec>
<sec>
<title>Results</title>
During the 17,699 person-years of follow-up (median, 15.2 y), 172 women experienced osteoporotic fractures. After adjustment for age and BMD at the total hip, the HRs compared with those of &amp;lt; 1 pack (approximately 40 g)/wk natto intake were 0.72 (95% CI: 0.52, 0.98) and 0.51 (95% CI: 0.30, 0.87) for 1–6 and ≥7 packs/wk, respectively. After further adjustment for BMI, history of osteoporotic fractures, history of myocardial infarction or stroke, diabetes mellitus, current smoking, alcohol intake, frequency of tofu and other soybean product intakes, and dietary calcium intake, the HRs were 0.79 (95% CI: 0.56, 1.10) and 0.56 (95% CI: 0.32, 0.99) for 1–6 and ≥7 packs/wk, respectively. Frequency of tofu or other soybean product intakes had no association with the risk of osteoporotic fractures.


</sec>
<sec>
<title>Conclusions</title>
Habitual natto intake may be associated with a reduced risk of osteoporotic fractures independent of confounding factors, including BMD, in Japanese postmenopausal women. This trial was registered at umin.ac.jp as UMIN 000032869.


</sec>

リンク情報
DOI
https://doi.org/10.1093/jn/nxz292
URL
http://academic.oup.com/jn/article-pdf/150/3/599/32537202/nxz292.pdf

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