1998年11月
Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism
EUROPEAN JOURNAL OF ENDOCRINOLOGY
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- 巻
- 139
- 号
- 5
- 開始ページ
- 522
- 終了ページ
- 527
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1530/eje.0.1390522
- 出版者・発行元
- SCANDINAVIAN UNIVERSITY PRESS
Bone mineral density (BMD) at distal forearm, and weight and height of healthy Japanese girls aged 18-19 years were measured and their age at menarche was obtained through a questionnaire, A statistically significant association was found between BMD at distal radius and vitamin D receptor (VDR) gene polymorphism at the ApaI site. The age at menarche in the population with An genotype was significantly earlier than that in the nit population. In addition, BMD was significantly dependent on the earlier onset of menarche in the population with genotype An but not in the population with genotype fin. EMD was also positively associated with the body mass index (BMI) in the population with genotype An. Statistical analysis suggested a stronger effect of VDR genotype on age at menarche than on BMI. Thus, we show that VDR gene polymorphism advances the age at menarche and increases BMD in cooperation with age at menarche.
- リンク情報
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- DOI
- https://doi.org/10.1530/eje.0.1390522
- CiNii Articles
- http://ci.nii.ac.jp/naid/30015209023
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/9849817
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000077242100011&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1530/eje.0.1390522
- ISSN : 0804-4643
- CiNii Articles ID : 30015209023
- PubMed ID : 9849817
- Web of Science ID : WOS:000077242100011