1992年
A STUDY OF MAST-CELLS IN AUTOIMMUNE NZB/W F1-MICE - POSSIBLE RELATIONSHIP BETWEEN MAST-CELLS AND INCREASED VASCULAR-PERMEABILITY IN THE THYMUS OF NZB/W F1-MICE
AUTOIMMUNITY
- ,
- 巻
- 14
- 号
- 2
- 開始ページ
- 137
- 終了ページ
- 142
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- HARWOOD ACAD PUBL GMBH
We examined the possible relationship between thymic mast cells and increased vascular permeability in the thymus of autoimmune NZB/W F1 mice. Light-microscopic observation of tissue sections showed that non-autoimmune BDF1 mast cells increased with age. In contrast, autoimmune NZB/W F1 mast cells did not increase in the thymic parenchyma at the age of 9 weeks. However, NZB/W F1 mast cells resumed the age-associated increase from the age of 12 weeks and exceeded the number of BDF, mast cells at the age of 30 weeks. Blood histamine levels of 9-week-old NZB/W F1 mice were higher than those of BDF1 mice of comparable age. Furthermore, peritoneal mast cells of NZB/W F1 mice were more sensitive to compound 48/80 than those of BDF1 mice. Increased blood histamine levels of NZB/W F1 mice seem to be due to the enhanced histamine release from mast cells. These results suggest a possible correlation between the high histamine levels by degranulation of mast cells and increased vascular permeability in the thymus of NZB/W F1 mice.
- リンク情報
- ID情報
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- ISSN : 0891-6934
- Web of Science ID : WOS:A1992KW80200008