二宮治明 (Haruaki Ninomiya) - マイポータル

基本情報

所属: 鳥取大学保健学科検査技術学専攻生体制御学教授

学位: 医学博士(京都大学)

J-GLOBAL ID: 200901081198302420
researchmap会員ID: 1000162678

外部リンク: http://www.ninomiya.med.tottori-u.ac.jp/homepage/

研究キーワード

研究分野

経歴

2008年 - 現在

鳥取大学医学部、教授
1998年 - 2001年

鳥取大学医学部、助教授
1998年 - 2001年

Associate Professor, Department of Neurobiology, Tottori University Faculty of Medicine
1993年 - 1998年

京都大学医学部、助手
1993年 - 1998年

Assistant professor, Department of Pharmacology Faculty of Medicine, Kyoto University
1992年 - 1993年

米国National Institute of Health 奨励研究員
1992年 - 1993年

Research fellow of Fogarty, International Research Fellowship, National Institute of Health, U.S.A.
1989年 - 1991年

日本学術振興会特別研究員
1989年 - 1991年

Research fellow of the Japan Society for the Promotion of Science for Japanese Junior Scientist

学歴

論文

Azelnidipine protects HL-1 cardiomyocytes from hypoxia/reoxygenation injury by enhancement of NO production independently of effects on gene expression.

Hiroyuki Minato, Ryo Endo, Yasutaka Kurata, Tomomi Notsu, Yoshiharu Kinugasa, Takayuki Wakimizu, Motokazu Tsuneto, Yasuaki Shirayoshi, Haruaki Ninomiya, Kazuhiro Yamamoto …

Heart and vessels 39(10) 899-908 2024年10月
Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells

Tomomi Notsu, Yasutaka Kurata, Haruaki Ninomiya, Fikri Taufiq, Koji Komatsu, Junichiro Miake, Tatsuya Sawano, Motokazu Tsuneto, Yasuaki Shirayoshi, Ichiro Hisatome

Hypertension Research 2023年8月17日
Characterization of Urate Metabolism and Complications of Patients with Renal Hypouricemia.

Satoshi Miyazaki, Toshihiro Hamada, Tadahiro Isoyama, Shinichi Okada, Katsuyuki Tomita, Yusuke Endo, Masanari Kuwabara, Shinobu Sugihara, Kazuhide Ogino, Haruaki Ninomiya …

Internal medicine (Tokyo, Japan) 62(13) 1915-1920 2022年11月23日
Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes.

Peili Li, Yasutaka Kurata, Fikri Taufiq, Masanari Kuwabara, Haruaki Ninomiya, Katsumi Higaki, Motokazu Tsuneto, Yasuaki Shirayoshi, Miguel A Lanaspa, Ichiro Hisatome

Molecular biology reports 49(7) 5939-5952 2022年7月
Hsp70 promotes maturation of uromodulin mutants that cause familial juvenile hyperuricemic nephropathy and suppresses cellular damage

Sulistiyati Bayu Utami, Ryo Endo, Toshihiro Hamada, Tomomi Notsu, Hiroyuki Minato, Koji Komatsu, Yuji Nakayama, Yasuaki Shirayoshi, Kazuhiro Yamamoto, Shinichi Okada …

CLINICAL AND EXPERIMENTAL NEPHROLOGY 26(6) 522-529 2022年6月
Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function

Satoshi Miyazaki, Toshihiro Hamada, Shinobu Sugihara, Einosuke Mizuta, Yusuke Endo, Akira Ohtahara, Koji Komatsu, Masanari Kuwabara, Tomoko Fukuuchi, Kiyoko Kaneko …

Internal Medicine 61(9) 1383-1386 2022年5月1日査読有り
α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats

Hiromu Horie, Ichiro Hisatome, Yasutaka Kurata, Yasutaka Yamamoto, Tomomi Notsu, Maaya Adachi, Peili Li, Masanari Kuwabara, Takuki Sakaguchi, Yoshiharu Kinugasa …

Hypertension Research 2021年12月1日
Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction.

Mai Watanabe, Hiromu Horie, Yasutaka Kurata, Yumiko Inoue, Tomomi Notsu, Takayuki Wakimizu, Maya Adachi, Kenshiro Yamamoto, Kumi Morikawa, Masanari Kuwabara …

Circulation journal : official journal of the Japanese Circulation Society 85(5) 657-666 2021年4月23日
Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia.

Ichiro Hisatome, Peili Li, Junichiro Miake, Fikri Taufiq, Endang Mahati, Nani Maharani, Sulistiyati Bayu Utami, Masanari Kuwabara, Udin Bahrudin, Haruaki Ninomiya

Circulation journal : official journal of the Japanese Circulation Society 85(2) 130-138 2021年1月25日
Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock(和訳中)

Otani Naoyuki, Kurata Yasutaka, Maharani Nani, Kuwabara Masanari, Ikeda Nobuhito, Notsu Tomomi, Li Peili, Miake Junichiro, Yoshida Akio, Sakaguchi Hiromi …

Circulation Reports 2(8) 425-432 2020年8月
Ultrastructure of spinal anterior horn cells in human Niemann-Pick type C (NPC) patient and mouse model of NPC with retroposon insertion in NPC1 genes

Masahiro Kusunoki-Ii, Hiroshi Kohama, Kiyota Kato, Yoshiko Nomura, Kazuo Nagashima, Haruaki Ninomiya, Masako Kato, Shinsuke Kato

Pathology International 70(7) 422-432 2020年7月1日
Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages

Fikri Taufiq, Peili Li, Masanari Kuwabara, Yasutaka Kurata, Toshihiro Hamada, Aiko Takami, Junichiro Miake, Motokazu Tsuneto, Yasuaki Shirayoshi, Kimiyoshi Ichida …

Vascular Failure 3(2) 59-67 2020年4月24日
β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction.

Adachi M, Watanabe M, Kurata Y, Inoue Y, Notsu T, Yamamoto K, Horie H, Tanno S, Morita M, Miake J …

Circulation journal : official journal of the Japanese Circulation Society 83(11) 2282-2291 2019年10月25日査読有り
Inhibitory effects of class I antiarrhythmic agents on Na+ and Ca2+ currents of human iPS cell-derived cardiomyocytes.

Sayaka Yonemizu, Keiichiro Masuda, Yasutaka Kurata, Tomomi Notsu, Yuhei Higashi, Kenta Fukumura, Peili Li, Haruaki Ninomiya, Junichiro Miake, Motokazu Tsuneto …

Regenerative therapy 10 104-111 2019年6月査読有り
Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes

Fikri Taufiq, Nani Maharani, Peili Li, Yasutaka Kurata, Nobuhito Ikeda, Masanari Kuwabara, Naoyuki Otani, Junichiro Miake, Akira Hasegawa, Motokazu Tsuneto …

Circulation journal : official journal of the Japanese Circulation Society 83(4) 718-726 2019年3月査読有り
Pretreatment with an angiotensin II receptor blocker abolished ameliorating actions of adipose-derived stem cell sheets on cardiac dysfunction and remodeling after myocardial infarction.

Kenshiro Yamamoto, Yasutaka Kurata, Yumiko Inoue, Maya Adachi, Motokazu Tsuneto, Junichiro Miake, Kazuhide Ogino, Haruaki Ninomiya, Akio Yoshida, Yasuaki Shirayoshi …

Regenerative therapy 9 79-88 2018年12月査読有り
Pretreatment with topiroxostat and irbesartan improves cardiac function after myocardial infarction in rats

Shogo Tanno, Shinobu Sugihara, Kenshiro Yamamoto, Maya Adachi, Yumiko Inoue, Naoyuki Otani, Kazuhiko Iituka, Kazuyoshi Ogura, Masaru Kato, Junichiro Miake …

Vascular Failure 2(2) 74-79 2018年3月31日
Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts.

Shogo Tanno, Kenshiro Yamamoto, Yasutaka Kurata, Maya Adachi, Yumiko Inoue, Naoyuki Otani, Mutsuo Mishima, Yasutaka Yamamoto, Masanari Kuwabara, Kazuhide Ogino …

Circulation journal : official journal of the Japanese Circulation Society 82(4) 1101-1111 2018年3月23日査読有り
Restoration of mutant hERG stability by inhibition of HDAC6.

Peili Li, Yasutaka Kurata, Mahati Endang, Haruaki Ninomiya, Katsumi Higaki, Fikri Taufiq, Kumi Morikawa, Yasuaki Shirayoshi, Minoru Horie, Ichiro Hisatome

Journal of molecular and cellular cardiology 115 158-169 2018年2月
Inhibitory effects of local anesthetics on the proteasome and their biological actions

Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama …

SCIENTIFIC REPORTS 7(1) 5079 2017年7月査読有り