中谷和彦 (Kazuhiko Nakatani) - マイポータル

基本情報

所属: 大阪大学産業科学研究所教授

学位: 理学博士

J-GLOBAL ID: 200901090595037490
researchmap会員ID: 1000162807

研究キーワード

ミスマッチ結合分子 SNP検出ドラッグの分子設計核酸ードラッグ複合体トリプレットリピート

研究分野

学歴

委員歴

1993年

日本化学会トピックス委員

受賞

論文

115

Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit

Hsiu-Ting Hsu, Asako Murata, Chikara Dohno, Kazuhiko Nakatani, KungYao Chang

NUCLEIC ACIDS RESEARCH 50(9) 5369-5383 2022年5月
HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules.

Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani

Molecular therapy. Nucleic acids 27 165-174 2022年3月8日
CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy.

Yuhei Hasuike, Hana Tanaka, Terence Gall-Duncan, Mustafa Mehkary, Kazuhiko Nakatani, Christopher E Pearson, Shoji Tsuji, Hideki Mochizuki, Masayuki Nakamori

Neurobiology of disease 163 105604-105604 2022年2月
Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 2022年2月
p Possibilities and challenges of small molecule organic compounds for the treatment of repeat diseases

Kazuhiko Nakatani

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 98(1) 30-48 2022年1月
2-Amino-1,8-naphthyridine Dimer (ANP77), a High-Affinity Binder to the Internal Loops of C/CC and T/CC Sites in Double-Stranded DNA

Bimolendu Das, Konami Nagano, Gota Kawai, Asako Murata, Kazuhiko Nakatani

JOURNAL OF ORGANIC CHEMISTRY 87(1) 340-350 2021年12月
FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability

Amit Laxmikant Deshmukh, Marie-Christine Caron, Mohiuddin Mohiuddin, Stella Lanni, Gagan B. Panigrahi, Mahreen Khan, Worrawat Engchuan, Natalie Shum, Aisha Faruqui, Peixiang Wang, Ryan K. C. Yuen, Masayuki Nakamori, Kazuhiko Nakatani, Jean-Yves Masson, Christopher E. Pearson

CELL REPORTS 37(10) 110078-110078 2021年12月
Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation.

Patryk Konieczny, Sanjukta Mukherjee, Ewa Stepniak-Konieczna, Katarzyna Taylor, Daria Niewiadomska, Agnieszka Piasecka, Agnieszka Walczak, Anna Baud, Chikara Dohno, Kazuhiko Nakatani, Krzysztof Sobczak

Nucleic acids research 49(16) 9479-9495 2021年9月20日
Short Tandem Repeat Contractions during in vitro DNA Synthesis by Repeat-Binding Molecules

Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiro Sugimoto, Yuta Hishinuma, Yuri Sohma, Tomonori Shibata, Kazuhiko Nakatani

Chemistry Letters 50(11) 1848-1851 2021年9月7日
A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules

Bimolendu Das, Asako Murata, Kazuhiko Nakatani

NUCLEIC ACIDS RESEARCH 49(15) 8462-8470 2021年9月
Ab initio multi-level layered elongation method and its application to local interaction analysis between DNA bulge and ligand molecules

Keisuke Hisama, Yuuichi Orimoto, Anna Pomogaeva, Kazuhiko Nakatani, Yuriko Aoki

JOURNAL OF CHEMICAL PHYSICS 155(4) 2021年7月
Speeding drug discovery targeting RNAs: An iterative "RNA selection-compounds screening cycle" for exploring RNA-small molecule pairs

Tomoko Furuzono, Asako Murata, Satoshi Okuda, Kenji Mizutani, Tsuyoshi Adachi, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY 36 2021年4月
Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.

Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani

Chemical communications (Cambridge, England) 57(26) 3235-3238 2021年3月1日
Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction.

Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Bimolendu Das, Yusuke Takashima, Kazuhiko Nakatani

Biochemistry 60(4) 245-249 2021年2月2日
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model.

Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani

Nature communications 12(1) 236-236 2021年1月11日
Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer

Nadja A. Simeth, Shotaro Kobayashi, Piermichele Kobauri, Stefano Crespi, Wiktor Szymanski, Kazuhiko Nakatani, Chikara Dohno, Ben L. Feringa

Chemical Science 12(26) 9207-9220 2021年
Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat.

Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani

Biochemistry 59(29) 2679-2683 2020年7月28日
The dimeric form of 1,3-diaminoisoquinoline derivative rescued the mis-splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model.

Kazuhiko Nakatani, Jun Matsumoto, Masayuki Nakamori, Tatsumasa Okamoto, Asako Murata, Chikara Dohno

Chemistry (Weinheim an der Bergstrasse, Germany) 2020年5月25日査読有り
Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands.

Lu Ni, Takeshi Yamada, Kazuhiko Nakatani

Chemical communications (Cambridge, England) 2020年4月28日査読有り
Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats

Mukherjee, S, Błaszczyk, L, Rypniewski, W, Falschlunger, C, Micura, R, Murata, A, Dohno, C, Nakatani, K, Kiliszek, A

Nucl. Acids Res. 47(20) 10906-10913 2019年11月査読有り

もっとみる

MISC

174

Cover Picture: A Ligand That Targets CUG Trinucleotide Repeats (Chem. Eur. J. 42/2016)

Jinxing Li, Jun Matsumoto, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani

Chemistry - A European Journal 22(42) 14757 2016年10月10日
The Chemistry of PCR Primers: Concept and Application

Fumie Takei, Kazuhiko Nakatani

ISRAEL JOURNAL OF CHEMISTRY 53(6-7) 401-416 2013年6月
Noncovalent Assembly of TEMPO Radicals Pair-wise Embedded on a DNA Duplex

Hiroshi Atsumi, Kensuke Maekawa, Shigeaki Nakazawa, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMISTRY LETTERS 39(6) 556-557 2010年6月
Noncovalent Assembly of TEMPO Radicals Pair-wise Embedded on a DNA Duplex

Hiroshi Atsumi, Kensuke Maekawa, Shigeaki Nakazawa, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMISTRY LETTERS 39(6) 556-557 2010年6月
A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA

Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(7) 2350-2353 2010年4月
A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA

Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(7) 2350-2353 2010年4月
Fluorescent Indicator Displacement Assay for Ligand-RNA Interactions

Jinhua Zhang, Shiori Umemoto, Kazuhiko Nakatani

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(11) 3660-+ 2010年3月
Fluorescent Indicator Displacement Assay for Ligand-RNA Interactions

Jinhua Zhang, Shiori Umemoto, Kazuhiko Nakatani

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(11) 3660-+ 2010年3月
Programmed assembly of organic radicals on DNA

Kensuke Maekawa, Shigeaki Nakazawa, Hiroshi Atsumi, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(8) 1247-1249 2010年
DNA crosslink tonatural base by a formyl group-containing DNA

2010年
The Development of The Displacement Assay, Screening Method for Detecting the RNA-ligand Interactions (2)

2010年
Spin labeling of DNA by using radical-containing mismatch binding ligands

2010年
The motion between (CGG)n containing hairpin DNA and G-G mismatch binding molecule

2010年
Transformation of cytosine to uracil in single-stranded DNA via their oxime sulfonates

Yoshimi Oka, Fumie Takei, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(19) 3378-3380 2010年
The Development of The Displacement Assay, Screening Method for Detecting the RNA-ligand Interactions (2)

2010年
The motion between (CGG)n containing hairpin DNA and G-G mismatch binding molecule

2010年
Spin labeling of DNA by using radical-containing mismatch binding ligands

2010年
DNA crosslink tonatural base by a formyl group-containing DNA

2010年
Programmed assembly of organic radicals on DNA

Kensuke Maekawa, Shigeaki Nakazawa, Hiroshi Atsumi, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(8) 1247-1249 2010年
Transformation of cytosine to uracil in single-stranded DNA via their oxime sulfonates

Yoshimi Oka, Fumie Takei, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(19) 3378-3380 2010年

もっとみる

中谷和彦

基本情報

研究キーワード

研究分野

学歴

委員歴

受賞

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

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