中谷和彦 (Kazuhiko Nakatani) - マイポータル

基本情報

所属: 大阪大学産業科学研究所教授

学位: 理学博士

J-GLOBAL ID: 200901090595037490

研究キーワード

ミスマッチ結合分子 SNP検出ドラッグの分子設計核酸ードラッグ複合体トリプレットリピート

研究分野

学歴

委員歴

1993年

日本化学会トピックス委員

受賞

論文

Small molecule-induced trinucleotide repeat contractions during in vitro DNA synthesis.

Chikara Dohno, Masaki Hagihara, Nursakinah Binti Mohd Zaifuddin, Mizuki Nihei, Kaoru Saito, Kazuhiko Nakatani

Chemical communications (Cambridge, England) 2021年3月1日
Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction.

Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Bimolendu Das, Yusuke Takashima, Kazuhiko Nakatani

Biochemistry 60(4) 245 - 249 2021年2月2日
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model.

Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani

Nature communications 12(1) 236 - 236 2021年1月11日
Chemical Probing of Thymine in the TGG/CGG Triad to Explore the Deamination of 5-Methylcytosine in the CGG Repeat.

Yuki Yagi, Takeshi Yamada, Kazuhiko Nakatani

Biochemistry 59(29) 2679 - 2683 2020年7月28日
The dimeric form of 1,3-diaminoisoquinoline derivative rescued the mis-splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model.

Kazuhiko Nakatani, Jun Matsumoto, Masayuki Nakamori, Tatsumasa Okamoto, Asako Murata, Chikara Dohno

Chemistry (Weinheim an der Bergstrasse, Germany) 2020年5月25日査読有り
Assembly of ruthenium complexes on double stranded DNA using mismatch binding ligands.

Lu Ni, Takeshi Yamada, Kazuhiko Nakatani

Chemical communications (Cambridge, England) 2020年4月28日査読有り
Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats

Mukherjee, S, Błaszczyk, L, Rypniewski, W, Falschlunger, C, Micura, R, Murata, A, Dohno, C, Nakatani, K, Kiliszek, A

Nucl. Acids Res. 47(20) 10906 - 10913 2019年11月査読有り
Modulating RNA secondary and tertiary structures by mismatch binding ligands.

Murata A, Nakamori M, Nakatani K

Methods (San Diego, Calif.) 2019年5月査読有り
Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer.

Otabe T, Nagano K, Kawai G, Murata A, Nakatani K

Bioorganic & medicinal chemistry 27(10) 2140 - 2148 2019年5月査読有り
A Dimeric 2,9-Diamino-1,10-phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models.

Li J, Nakamori M, Matsumoto J, Murata A, Dohno C, Kiliszek A, Taylor K, Sobczak K, Nakatani K

Chemistry (Weinheim an der Bergstrasse, Germany) 24(68) 18115 - 18122 2018年12月査読有り
CGG repeat DNA assisted dimerization of CGG/CGG binding molecule through intermolecular disulfide formation.

Yamada T, Miki S, Ni L, Nakatani K

Chemical communications (Cambridge, England) 54(93) 13072 - 13075 2018年11月査読有り
Expanding chemical space of DNA-binding molecules with three base-binding units.

Yagi Y, Aikawa H, Yamada T, Nakatani K

Bioorganic & medicinal chemistry letters 28(17) 2894 - 2898 2018年9月査読有り
Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.

Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K

Nucleic acids research 46(16) 8079 - 8089 2018年9月査読有り
Bicyclic and tricyclic C-C mismatch-binding ligands bind to CCG trinucleotide repeat DNAs.

Shibata T, Nakatani K

Chemical communications (Cambridge, England) 54(51) 7074 - 7077 2018年6月査読有り
Restoration of Ribozyme Tertiary Contact and Function by Using a Molecular Glue for RNA

Chikara Dohno, Maki Kimura, Kazuhiko Nakatani

Angewandte Chemie - International Edition 57(2) 506 - 510 2018年1月8日査読有り
1,3-Di(quinolin-2-yl)guanidine binds to GGCCCC hexanucleotide repeat DNA in C9ORF72

Tomonori Shibata, Eitaro Murakami, Kazuhiko Nakatani

Bioorganic and Medicinal Chemistry Letters 28(14) 2364 - 2368 2018年査読有り
Synthesis of Naphthyridine Dimers with Conformational Restriction and Binding to DNA and RNA

Kazuhiko Nakatani, Nozomi Natsuhara, Yuki Mori, Sanjukta Mukherjee, Bimolendu Das, Asako Murata

CHEMISTRY-AN ASIAN JOURNAL 12(23) 3077 - 3087 2017年12月査読有り
Synthetic ligand promotes gene expression by affecting GC sequence in promoter

Saki Matsumoto, Kei Iida, Asako Murata, Masatsugu Denawa, Masatoshi Hagiwara, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(15) 3391 - 3394 2017年8月査読有り
Design and Synthesis of Cyclic Mismatch-Binding Ligands (CMBLs) with Variable Linkers by Ring-Closing Metathesis and their Photophysical and DNA Repeat Binding Properties

Sanjukta Mukherjee, Chikara Dohno, Kazuhiko Nakatani

CHEMISTRY-A EUROPEAN JOURNAL 23(47) 11385 - 11396 2017年8月査読有り
Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G-G Mismatch DNA

Takeshi Yamada, Shouta Miki, Anisa Ul'Husna, Akiko Michikawa, Kazuhiko Nakatani

ORGANIC LETTERS 19(16) 4163 - 4166 2017年8月査読有り

もっとみる

MISC

173

Cover Picture: A Ligand That Targets CUG Trinucleotide Repeats (Chem. Eur. J. 42/2016)

Jinxing Li, Jun Matsumoto, Li-Ping Bai, Asako Murata, Chikara Dohno, Kazuhiko Nakatani

Chemistry - A European Journal 22(42) 14757 2016年10月10日
The Chemistry of PCR Primers: Concept and Application

Fumie Takei, Kazuhiko Nakatani

ISRAEL JOURNAL OF CHEMISTRY 53(6-7) 401 - 416 2013年6月
Noncovalent Assembly of TEMPO Radicals Pair-wise Embedded on a DNA Duplex

Hiroshi Atsumi, Kensuke Maekawa, Shigeaki Nakazawa, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMISTRY LETTERS 39(6) 556 - 557 2010年6月
Noncovalent Assembly of TEMPO Radicals Pair-wise Embedded on a DNA Duplex

Hiroshi Atsumi, Kensuke Maekawa, Shigeaki Nakazawa, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMISTRY LETTERS 39(6) 556 - 557 2010年6月
A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA

Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(7) 2350 - 2353 2010年4月
A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA

Masaki Hagihara, Keisuke Yoneda, Hiroaki Yabuuchi, Yasushi Okuno, Kazuhiko Nakatani

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(7) 2350 - 2353 2010年4月
Fluorescent Indicator Displacement Assay for Ligand-RNA Interactions

Jinhua Zhang, Shiori Umemoto, Kazuhiko Nakatani

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(11) 3660 - + 2010年3月
Fluorescent Indicator Displacement Assay for Ligand-RNA Interactions

Jinhua Zhang, Shiori Umemoto, Kazuhiko Nakatani

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(11) 3660 - + 2010年3月
Programmed assembly of organic radicals on DNA

Kensuke Maekawa, Shigeaki Nakazawa, Hiroshi Atsumi, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(8) 1247 - 1249 2010年
DNA crosslink tonatural base by a formyl group-containing DNA

2010年
The Development of The Displacement Assay, Screening Method for Detecting the RNA-ligand Interactions (2)

2010年
Spin labeling of DNA by using radical-containing mismatch binding ligands

2010年
The motion between (CGG)n containing hairpin DNA and G-G mismatch binding molecule

2010年
Transformation of cytosine to uracil in single-stranded DNA via their oxime sulfonates

Yoshimi Oka, Fumie Takei, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(19) 3378 - 3380 2010年
The Development of The Displacement Assay, Screening Method for Detecting the RNA-ligand Interactions (2)

2010年
The motion between (CGG)n containing hairpin DNA and G-G mismatch binding molecule

2010年
Spin labeling of DNA by using radical-containing mismatch binding ligands

2010年
DNA crosslink tonatural base by a formyl group-containing DNA

2010年
Programmed assembly of organic radicals on DNA

Kensuke Maekawa, Shigeaki Nakazawa, Hiroshi Atsumi, Daisuke Shiomi, Kazunobu Sato, Masahiro Kitagawa, Takeji Takui, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(8) 1247 - 1249 2010年
Transformation of cytosine to uracil in single-stranded DNA via their oxime sulfonates

Yoshimi Oka, Fumie Takei, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS 46(19) 3378 - 3380 2010年

もっとみる

中谷和彦

基本情報

研究キーワード

研究分野

学歴

委員歴

受賞

論文

MISC

所属学協会

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