2020年3月6日
Tandem C-H Transformations by a Single Iridium Catalyst: Direct Access to Indoles and Indolines from o-Alkyl-N-methylanilines
ACS Catalysis
- ,
- ,
- ,
- 巻
- 10
- 号
- 5
- 開始ページ
- 3152
- 終了ページ
- 3157
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acscatal.9b05579
In the presence of an iridium catalyst bearing DTBM-SEGPHOS as a ligand and tert-butylethylene as a hydrogen scavenger, 2-ethyl-N-methylanilines were converted directly to 3-methylindoles in high yields. The reaction proceeded efficiently in mesitylene at 150 °C through transfer dehydrogenation of the ethyl group and following intramolecular dehydrogenative C-H/C-H coupling of the N-methyl group with the vinyl group formed in situ. The iridium catalyst system was applied to the asymmetric conversion affording enantioenriched indolines bearing a quaternary stereogenic carbon center at the C3 position.
- リンク情報
- ID情報
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- DOI : 10.1021/acscatal.9b05579
- ISSN : 2155-5435
- eISSN : 2155-5435
- SCOPUS ID : 85080043426