2011年5月
Anthranilamide: A Simple, Removable ortho-Directing Modifier for Arylboronic Acids Serving also as a Protecting Group in Cross-Coupling Reactions
ORGANIC LETTERS
- ,
- ,
- 巻
- 13
- 号
- 10
- 開始ページ
- 2662
- 終了ページ
- 2665
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ol200764g
- 出版者・発行元
- AMER CHEMICAL SOC
Anthranilamide (AAM) serves as a bifunctional modifier on the boron atom in catalytic transformations of arylboronic acids. It makes boronyl groups unreactive in Suzuki-Miyaura coupling and promotes Ru-catalyzed ortho-silylation. Suzuki-Miyaura coupling of AAM-modified bromophenylboronic acids with tolylboronic acid gave 1,1'-biaryl-4-boronic acid bearing AAM on the boron atom, which subsequently underwent Ru-catalyzed ortho-silylation at the 3-position by virtue of the ortho-directing effect of the AAM group.
- リンク情報
- ID情報
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- DOI : 10.1021/ol200764g
- ISSN : 1523-7060
- Web of Science ID : WOS:000290465800039