2009年8月
Nickel-Catalyzed Ring-Opening Hydroacylation of Methylenecyclopropanes: Synthesis of gamma,delta-Unsaturated Ketones from Aldehydes
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ,
- ,
- 巻
- 131
- 号
- 32
- 開始ページ
- 11298
- 終了ページ
- +
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ja9046894
- 出版者・発行元
- AMER CHEMICAL SOC
A nickel-catalyzed intermolecular hydroacylation of methylenecyclopropanes (MCPs) has been developed. The reaction proceeds with stereospecific cleavage of the proximal C-C bond of the cyclopropane ring to give gamma,delta-unsaturated ketones with high diastereoselectivities. A nickel catalyst generated in situ from Ni(cod)(2) and P(n-Bu)(3) with a P/Ni ratio of 1:1 is effective for the hydroacylation, in which benzaldehyde derivatives, heteroaryl aldehydes, and aliphatic aldehydes react with MCPs at 60-100 degrees C to afford the corresponding ketones in high yields,
- リンク情報
- ID情報
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- DOI : 10.1021/ja9046894
- ISSN : 0002-7863
- Web of Science ID : WOS:000269379200014