山口宏 (Hiroshi Yamaguchi) - マイポータル

基本情報

所属: 関西学院大学理工学部化学科教授

学位: 理学博士(大阪大学)

J-GLOBAL ID: 200901065174428606
researchmap会員ID: 1000163190

研究キーワード

研究分野

経歴

2008年10月 - 現在

関西学院大学, 理工学部, 教授
2002年10月 - 2008年9月

関西学院大学, 理工学部, 助教授／准教授
1997年4月 - 2002年10月

関西学院大学, 理学部, 専任講師
1992年10月 - 1997年3月

大阪大学, 蛋白質研究所, 助手

論文

Inhibitory effects of local anesthetics on the proteasome and their biological actions.

U. Bahrudin, M. Unno, K. Nishio, A. Kita, P. Li, M. Kato, M. Inoue, S. Tsujitani, T. Murakami, R. Sugiyama …

Scientific Reports. 7 5079 2017年査読有り
Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions

Takeshi Murakawa, Akio Hamaguchi, Shota Nakanishi, Misumi Kataoka, Tadashi Nakai, Yoshiaki Kawano, Hiroshi Yamaguchi, Hideyuki Hayashi, Katsuyuki Tanizawa, Toshihide Okajima

JOURNAL OF BIOLOGICAL CHEMISTRY 290(38) 23094-23109 2015年9月査読有り
Inhibition of the Functional Interplay between Endoplasmic Reticulum (ER) Oxidoreduclin-1 alpha (Ero1 alpha) and Protein-disulfide Isomerase (PDI) by the Endocrine Disruptor Bisphenol A

Masaki Okumura, Hiroshi Kadokura, Shoko Hashimoto, Katsuhide Yutani, Shingo Kanemura, Takaaki Hikima, Yuji Hidaka, Len Ito, Kohei Shiba, Shoji Masui …

JOURNAL OF BIOLOGICAL CHEMISTRY 289(39) 27004-27018 2014年9月査読有り
Radically Different Thioredoxin Domain Arrangement of ERp46, an Efficient Disulfide Bond Introducer of the Mammalian PDI Family

Rieko Kojima, Masaki Okumura, Shoji Masui, Shingo Kanemura, Michio Inoue, Masatoshi Saiki, Hiroshi Yamaguchi, Takaaki Hikima, Mamoru Suzuki, Shuji Akiyama …

STRUCTURE 22(3) 431-443 2014年3月査読有り
Weak interaction of an inhibitor in the 20S proteasome.

T. Murakami, H. Yamaguchi, U. Bahrudin, A. Kita, I. Hisatome, Y. Saeki, K. Tanaka, M. Unno, Y. Morimoto

Acta Crystarogr. A70 C487 2014年査読有り
Glutathione Ethylester, a Novel Protein Refolding Reagent, Enhances both the Efficiency of Refolding and Correct Disulfide Formation

Len Ito, Masaki Okumura, Kohsaku Tao, Yusuke Kasai, Shunsuke Tomita, Akiko Oosuka, Hidetoshi Yamada, Tomohisa Shibano, Kentaro Shiraki, Takashi Kumasaka …

PROTEIN JOURNAL 31(6) 499-503 2012年8月査読有り
Crystallization and preliminary crystallographic analysis of the complex between triiodothyronine and the bb ' fragment of rat protein disulfide isomerase

Shoko Hashimoto, Len Ito, Masaki Okumura, Tomohisa Shibano, Marina Nawata, Takashi Kumasaka, Hiroshi Yamaguchi, Susumu Imaoka

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 68 476-478 2012年4月査読有り
Effect of Surface Defects on Auger Recombination in Colloidal CdS Quantum Dots

Yoichi Kobayashi, Takatoshi Nishimura, Hiroshi Yamaguchi, Naoto Tamai

JOURNAL OF PHYSICAL CHEMISTRY LETTERS 2(9) 1051-1055 2011年5月査読有り
Acceleration of disulfide-coupled protein folding using glutathione derivatives

Masaki Okumura, Masatoshi Saiki, Hiroshi Yamaguchi, Yuji Hidaka

FEBS JOURNAL 278(7) 1137-1144 2011年4月査読有り
High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine

Len Ito, Kentaro Shiraki, Takanori Matsuura, Masaki Okumura, Kazuya Hasegawa, Seiki Baba, Hiroshi Yamaguchi, Takashi Kumasaka

PROTEIN ENGINEERING DESIGN & SELECTION 24(3) 269-274 2011年3月査読有り
Detection of the reaction intermediates catalyzed by a copper amine oxidase

Misumi Kataoka, Hiroko Oya, Ayuko Tominaga, Masayuki Otsu, Toshihide Okajima, Katsuyuki Tanizawa, Hiroshi Yamaguchi

JOURNAL OF SYNCHROTRON RADIATION 18 58-61 2011年1月査読有り
Fiber Formation of a Synthetic Spider Peptide Derived From Nephila clavata

Yuji Hidaka, Ko-Ichi Kontani, Rina Taniguchi, Masatoshi Saiki, Sayoko Yokoi, Kenji Yukuhiro, Hiroshi Yamaguchi, Mitsuhiro Miyazawa

BIOPOLYMERS 96(2) 222-227 2011年査読有り
Oxidative Folding of Prouroguanylin

Y. Yamazaki, M. Okumura, L. Ito, T. Maekawa, A. Matsuoka, Y. Yoshida, H. Yamaguchi, Y. Hidaka

Peptide Science 2010 47 164 2011年査読有り
Role of Leu66 in the Folding of Uroguanylin Assisted by the Pro-peptide Region

YAMAGUCHI Hiroshi

Peptide Science 2010 47 163 2011年査読有り
Heparin-Induced Conformational Change in the Extra-cellular Domain of the Precursor Protein of β-Amyloid

A. Matsuoka, M. Okumura, L. Ito, Y. Yamazaki, H. Yamaguchi, M. Niinobe, Y. Hidaka

Peptide Science 2010 47 162 2011年査読有り
A Novel Reagent for Disulfide-Coupled Protein Folding

M. Okumura, M. Saiki, H. Yamaguchi, Y. Hidaka

Peptide Science 2010 47 170 2011年査読有り
Crystallization and preliminary crystallographic analysis of Achromobacter protease I mutants

Len Ito, Kentaro Shiraki, Tatsuya Uchida, Masaki Okumura, Hiroshi Yamaguchi

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66 1531-1532 2010年11月査読有り
Comparative analysis of amino acids and amino-acid derivatives in protein crystallization

Len Ito, Kentaro Shiraki, Hiroshi Yamaguchi

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 66 744-749 2010年6月査読有り
Amino acids and glycine ethyl ester as new crystallization reagents for lysozyme

Len Ito, Kentaro Shiraki, Hiroshi Yamaguchi

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 66 750-754 2010年6月査読有り
Expression, Purification, and Crystallization of Proopiomelanocortin

K. Watanabe, Y. Hosokawa, L. Ito, A. Basak, H. Yamaguchi, Y. Hidaka

Pept.Sci.2008 45 469-472 2009年査読有り

もっとみる

MISC

銅含有アミン酸化酵素の翻訳後修飾トパキノン生成過程の時系列構造解析

山口宏, 金美沙

日本結晶学会誌 45, 262-267(4) 262-267 2003年
Role of copper ion in bacterial copper amine oxidase: Spectroscopic and crystallographic studies of metal-substituted enzymes

S Kishishita, T Okajima, M Kim, H Yamaguchi, S Hirota, S Suzuki, S Kuroda, K Tanizawa, M Mure

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(4) 1041-1055 2003年1月
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase

M Kim, T Okajima, S Kishishita, M Yoshimura, A Kawamori, K Tanizawa, H Yamaguchi

NATURE STRUCTURAL BIOLOGY 9(8) 591-596 2002年8月
銅含有アミン酸化酵素のトパキノン補酵素生成過程の研究

構造生物 8, 10-21 2002年
X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9Å resolution.(jointly worked)

Acta Crystallgraphica D56 529-535 2000年
Structure analysis of bovine heart cytochrome C oxidase at 2.8Å resolution

Acta Crystallographica D55(1) 31 1999年
CRYSTALLIZATION AND FURTHER CHARACTERIZATION OF META-HYDROXYBENZOATE 4-HYOROXYLASE FROM ┣DBMAUC COMAMONAS TESTOSTERONI(/)┫DB

Research Communications in Biochemistry, Cell and Molecular Biology 2(3&4) 253 1998年
Redox-Coupled Crystal Structural Changes in Bovine Heart Cytochrome C Oxidase(jointly worked)

Science 280(5370) 1723-1729 1998年
Crystal Structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo- and apo- forms : Implications for the biogenesis of topa quinone(jointly worked)

Biochemistry 36(51) 16116-16133 1997年
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8(]J1009[)(jointly worked)

Science 272(5265) 1136-1144 1996年
Structures of Metal Sites of Oxidiqed Bovine Heart Cytochrome c Oxidase at 2.8A

Science 269(5227) 1069-1074 1995年
Flexible loop that is novel catalitic machinery in a ligase Atomic structure and function of the loopless glutathione Synthetase(jointly worked)

Biochemistry 33(17) 4995-4999 1994年
グルタチオン合成酵素の構造と機能の解析(共著)

蛋白質核酸酵素 38(10) 1579 1993年
Structural and Functional Analysis on Glutathione Synthetase

Protein, Nucleic Acid and Enzyme 38(10) 1579 1993年
Flexibility Impaired by Mutations Revealed the Multifunctional Roles of the Loop in Glutathione Synthetase(jointly worked)

Biochemistry 32(46) 12398-12404 1993年
Use of Adenosine(5')-polyphospho(5')pyridoxals To Study the Substrate-Binding Region of Glutathione Synthetase from ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB B(jointly worked)

Biochemistry 32(6) 1548-1554 1993年
Three-dimensional Structure of the Glutathione Synthetase from ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB B at 2.0Å Resolution(jointly worked)

Journal of Molecular Biology 229(4) 1083 1993年
シトクロムC酸化酵素の立体構造を見る「(共著)」

蛋白質・核酸・酵素別刷見る技術 42(別刷7) 977
Three dimensional structure of the cytochrome C oxidase(jointly worked)

Protein, Nucleic Acid and Enzyme, Suppliment 7. 42(Sup.7) 977

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

初期発生関連タンパク質の構造生物学

大型放射光施設利用研究推進 1998年
m-ヒドロキシ安息香酸-4-水酸化酵素の結晶構造解析

1996年
フェニルエチルアミン酸化酵素の構造学的研究

科学研究費補助金 1995年
Structure Determination of m-hydroxybenzoate -4-hydroxylase
Structural Studies on Phenylethylamine Oxidase
Structural Studies on Adenylate kinase