青木俊二 (Shunji Aoki) - マイポータル

基本情報

学位: 修士(薬学)
薬学博士

J-GLOBAL ID: 200901053148042823
researchmap会員ID: 1000163223

研究キーワード

研究分野

ナノテク・材料 / 生物分子化学 /

論文

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs

Syuhei Nakao, Miyuki Mabuchi, Tadashi Shimizu, Yoshihiro Itoh, Yuko Takeuchi, Masahiro Ueda, Hiroaki Mizuno, Naoko Shigi, Ikumi Ohshio, Kentaro Jinguji …

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24(4) 1071-1074 2014年2月査読有り
Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells

Dexin Kong, Shunji Aoki, Yoshihiro Sowa, Toshiyuki Sakai, Motomasa Kobayashi

Marine Drugs 6(3) 480-488 2008年9月査読有り
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge

Naoyuki Kotoku, Atsushi Hiramatsu, Hiroaki Tsujita, Yoichi Hirakawa, Mami Sanagawa, Shunji Aoki, Motomasa Kobayashi

ARCHIV DER PHARMAZIE 341(9) 568-577 2008年9月査読有り
Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Masayoshi Arai, Hideaki Suna, Katsushiro Miyamoto, Hiroshi Tsujibo, Kazutake Tsujikawa, Hiroshi Yamamoto, Motomasa Kobayashi

Bioorganic and Medicinal Chemistry 15(21) 6758-6762 2007年11月1日査読有り
The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line

Taka-Aki Matsui, Yoshihiro Sowa, Hiroaki Murata, Koichi Takagi, Ryoko Nakanishi, Shunji Aoki, Masayuki Yoshikawa, Motomasa Kobayashi, Tomoya Sakabe, Toshikazu Kubo …

International Journal of Oncology 31(4) 915-922 2007年10月査読有り
P-35 海綿由来の血管新生阻害物質cortistatin類の構造活性相関と作用メカニズムの解析(ポスター発表の部)

古徳直之, 渡部康雄, 青木俊二, 住井裕司, 田辺大樹, 荒井雅吉, 小林資正

天然有機化合物討論会講演要旨集 (49) 341-346 2007年8月24日
Crambescidin 800, a pentacyclic guanidine alkaloid, protects a mouse hippocampal cell line against glutamate-induced oxidative stress

Hideaki Suna, Shunji Aoki, Andi Setiawan, Motomasa Kobayashi

Journal of Natural Medicines 61(3) 288-295 2007年7月査読有り
Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata

Shunji Aoki, Mami Sanagawa, Yasuo Watanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi

BIOORGANIC & MEDICINAL CHEMISTRY 15(14) 4818-4828 2007年7月査読有り
Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

Shunji Aoki, Yasuo Watanabe, Daiki Tanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi

TETRAHEDRON LETTERS 48(26) 4485-4488 2007年6月査読有り
15 海綿由来新規アルカロイドcortistatin類の化学構造とHUVECs選択的増殖抑制効果(口頭発表の部)

青木俊二, 渡部康雄, 真川万実, 田辺大樹, 古徳直之, 小林資正

天然有機化合物討論会講演要旨集 (48) 85-90 2006年9月15日
A functional role of intracellular loops of human multidrug resistance protein 1

Xiao-Qin Ren, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shunji Aoki, Motomasa Kobayashi, Masayuki Nakagawa, Shin-Ichi Akiyama

Journal of Biochemistry 140(3) 313-318 2006年9月査読有り
P-226 NOVEL POLYKETIDES, SHIMALACTONES A AND B, FROM A MARINE-DERIVED FUNGUS EMERICELLA VARIECOLOR GF10

Wei Hong, Itoh Takuya, Kotoku Naoyuki, Aoki Shunji, Kobayashi Motomasa

International Symposium on the Chemistry of Natural Products 2006 "P-226" 2006年7月23日
A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells

Moriatsu Izumi, Shingo Yogosawa, Shunji Aoki, Hirotsuna Watanabe, Jun Kamiyama, Yoshinori Takahara, Yoshihiro Sowa, Motomasa Kobayashi, Hajime Hosoi, Tohru Sugimoto …

International Journal of Oncology 29(1) 169-173 2006年7月査読有り
Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells

Shunji Aoki, Seok-Hwan Cho, Atsushi Hiramatsu, Naoyuki Kotoku, Motomasa Kobayashi

Journal of Natural Medicines 60(3) 231-235 2006年7月査読有り
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner

Shunji Aoki, Dexin Kong, Hideaki Suna, Yoshihiro Sowa, Toshiyuki Sakai, Andi Setiawan, Motomasa Kobayashi

Biochemical and Biophysical Research Communications 342(1) 101-106 2006年3月31日査読有り
Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex

S Aoki, Y Watanabe, M Sanagawa, A Setiawan, N Kotoku, M Kobayashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128(10) 3148-3149 2006年3月査読有り
Synthesis of 15,20-triamide analogue with polar substituent on the phenyl ring of arenastatin A, an extremely potent cytotoxic spongean depsipeptide

Naoyuki Kotoku, Tomoya Kato, Fuminori Narumi, Emiko Ohtani, Sayo Kamada, Shunji Aoki, Naoki Okada, Shinsaku Nakagawa, Motomasa Kobayashi

Bioorg. Med. Chem. 14(22) 7446-7457 2006年
101(P-36) 海綿由来の血管新生阻害物質bastadin 6の合成研究(ポスター発表の部)

古徳直之, 辻田博昭, 平松篤, 森千夏, 趙碩煥, 青木俊二, 小林資正

天然有機化合物討論会講演要旨集 (46) 581-586 2004年10月1日
Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp KS3

T Itoh, M Kinoshita, S Aoki, M Kobayashi

JOURNAL OF NATURAL PRODUCTS 66(10) 1373-1377 2003年10月査読有り
Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells

Motoi Mukai, Xiao-Fang Che, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Shunji Aoki, Xioa-Qin Ren, Misako Haraguchi, Yoshikazu Sugimoto, Motomasa Kobayashi, Hideo Takamatsu …

Cancer Science 94(6) 557-563 2003年6月1日査読有り

もっとみる

MISC

Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex

Yasuo Watanabe, Shunji Aoki, Daiki Tanabe, Andi Setiawan, Motomasa Kobayashi

TETRAHEDRON 63(19) 4074-4079 2007年5月
Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells.

Shunji Aoki, Seok Hwan Cho, Mayumi Ono, Takashi Kuwano, Shintaro Nakao, Michihiko Kuwano, Shinsaku Nakagawa, Jian Qing Gao, Tadanori Mayumi, Masabumi Shibuya …

Anti-Cancer Drugs 17 269-278 2006年3月1日
MRP1 mutated in the L0 region transports SN-38 but not Leukotriene C4 or estradiol-17 (-D-glucuronate).

Tomohiro Noguchi, Xiao-Qin Ren, Shunji Aoki, Yoshinobu Igarashi, Xiao-Fang Che, Yuichi Nakajima, Homare Takahashi, Ryoichi Mitsuo, Kazutake Tsujikawa, Tomoyuki Sumizawa …

Biochem. Pharmacol. 70(7) 1056-1065 2005年10月
Shimalactone A, a novel polyketide, from marine-derived fungus Emericella variecolor GF10

H Wei, T Itoh, M Kinoshita, N Kotoku, S Aoki, M Kobayashi

TETRAHEDRON 61(33) 8054-8058 2005年8月
血管新生阻害活性を有する海綿由来成分bastadin類のin vivo抗腫瘍効果及びその作用機序

青木俊二, 趙碩煥, 小野眞弓, 桑野信彦, 中川晋作, 高建青, 真弓忠範, 小林資正

日本薬学会年会要旨集 125年会(4) 180-180 2005年3月
Absolute stereo-structure of kendarimide a, a novel MDR modulator, from a marine sponge

N Kotoku, LW Cao, S Aoki, M Kobayashi

HETEROCYCLES 65(3) 563-578 2005年3月
GSH inhibits trypsinization of the C-terminal half of human MRP1

XQ Ren, T Furukawa, Y Nakajima, H Takahashi, S Aoki, T Sumizawa, M Haraguchi, M Kobayashi, K Chijiiwa, S Akiyama

JOURNAL OF BIOLOGICAL CHEMISTRY 280(7) 6231-6237 2005年2月
Kendarimide A, a novel peptide reversing P-glycoprotein-mediated multidrug resistance in tumor cells, from a marine sponge of Haliclona sp.

S Aoki, LW Cao, K Matsui, R Rachmat, S Akiyama, M Kobayashi

TETRAHEDRON 60(33) 7053-7059 2004年8月
Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells

S Aoki, D Kong, K Matsui, R Rachmat, M Kobayashi

CHEMICAL & PHARMACEUTICAL BULLETIN 52(8) 935-937 2004年8月
Erythroid differentiation in K562 chronic myelogenous cells induced by crambescidin 800, a pentacyclic guanidine alkaloid

S Aoki, DX Kong, K Matsui, M Kobayashi

ANTICANCER RESEARCH 24(4) 2325-2330 2004年7月
Function of the ABC signature sequences in the human multidrug resistance protein 1

XQ Ren, T Furukawa, M Haraguchi, T Sumizawa, S Aoki, M Kobayashi, S Akiyama

MOLECULAR PHARMACOLOGY 65(6) 1536-1542 2004年6月
Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells

S Aoki, D Kong, K Matsui, M Kobayashi

ANTI-CANCER DRUGS 15(4) 363-369 2004年4月
海洋真菌Emericella variecolorGF10株由来の新規ポリケタイドの化学構造

い宏, 伊藤卓也, 木下雅裕, 青木俊二, 小林資正

日本薬学会年会要旨集 124th(2) 2004年
Structure-activity relationship of neuritogenic spongean acetylene alcohols, lembehynes

S Aoki, K Matsui, H Wei, N Murakami, M Kobayashi

TETRAHEDRON 58(27) 5417-5422 2002年7月
Identification of GSH and drug binding sites on the human multidrug resistance protein (MRP1)

XQ Ren, T Furukawa, S Aoki, T Sumizawa, M Hariguchi, ZS Chen, S Akiyama

MOLECULAR BIOLOGY OF THE CELL 12 69A-69A 2001年11月
Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function

ZS Chen, S Aoki, M Komatsu, K Ueda, T Sumizawa, T Furukawa, H Okumura, XQ Ren, MG Belinsky, K Lee …

INTERNATIONAL JOURNAL OF CANCER 93(1) 107-113 2001年7月
Glutathione-dependent binding of a photoaffinity analog of agosterol A to the C-terminal half of human multidrug resistance protein

XQ Ren, T Furukawa, S Aoki, T Nakajima, T Sumizawa, M Haraguchi, ZS Chen, M Kobayashi, S Akiyama

JOURNAL OF BIOLOGICAL CHEMISTRY 276(25) 23197-23206 2001年6月
Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene

S Aoki, K Higuchi, N Isozumi, K Matsui, Y Miyamoto, N Itoh, K Tanaka, M Kobayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 282(2) 426-431 2001年3月
Molecular modeling of 5-desacetylaltohyrtin A, a spongean cytotoxic macrolide

S Aoki, N Nemoto, Y Kobayashi, M Kobayashi, Kitagawa, I

TETRAHEDRON 57(12) 2289-2292 2001年3月
Synthesis of amide analogs of arenastatin A

N Murakami, WQ Wang, N Ohyabu, T Ito, S Tamura, S Aoki, M Kobayashi, Kitagawa, I

TETRAHEDRON 56(46) 9121-9128 2000年11月

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青木俊二

基本情報

研究キーワード

研究分野

論文

MISC

所属学協会

Works(作品等)

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