MISC

査読有り
2014年12月

Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability

CANCER SCIENCE
  • Terasawa, Masahiro
  • ,
  • Shinohara, Akira
  • ,
  • Shinohara, Miki

105
12
開始ページ
1519
終了ページ
1525
記述言語
英語
掲載種別
書評論文,書評,文献紹介等
DOI
10.1111/cas.12551
出版者・発行元
WILEY-BLACKWELL

Double-strand breaks (DSBs) are one of the severest types of DNA damage. Unrepaired DSBs easily induce cell death and chromosome aberrations. To maintain genomic stability, cells have checkpoint and DSB repair systems to respond to DNA damage throughout most of the cell cycle. The failure of this process often results in apoptosis or genomic instability, such as aneuploidy, deletion, or translocation. Therefore, DSB repair is essential for maintenance of genomic stability. During mitosis, however, cells seem to suppress the DNA damage response and proceed to the next G(1) phase, even if there are unrepaired DSBs. The biological significance of this suppression is not known. In this review, we summarize recent studies of mitotic DSB repair and discuss the mechanisms of suppression of DSB repair during mitosis. DSB repair, which maintains genomic integrity in other phases of the cell cycle, is rather toxic to cells during mitosis, often resulting in chromosome missegregation and aberration. Cells have multiple safeguards to prevent genomic instability during mitosis: inhibition of 53BP1 or BRCA1 localization to DSB sites, which is important to promote non-homologous end joining or homologous recombination, respectively, and also modulation of the non-homologous end joining core complex to inhibit DSB repair. We discuss how DSBs during mitosis are toxic and the multiple safeguard systems that suppress genomic instability.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1111/cas.12551
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25287622
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346347600001&DestApp=WOS_CPL