論文

査読有り 国際誌
2021年7月5日

Effects of antibiotics on the viability of and toxin production by Clostridium botulinum.

Microbiology and immunology
  • Masahiro Yutani
  • ,
  • Takuhiro Matsumura
  • ,
  • Yukako Fujinaga

65
10
開始ページ
432
終了ページ
437
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/1348-0421.12928

Clostridium botulinum causes infant and adult intestinal botulism by colonizing in the intestine and producing botulinum neurotoxin (BoNT). Antimicrobial agents are not currently used for treatment due to the potential facilitation of BoNT production and bacterial cell lysis, which releases toxins into the intestinal lumen. In this study, we analyzed effects of four antibiotics on the viability of and BoNT production by four C. botulinum group I strains. Our results indicate that metronidazole rapidly reduced their viability without enhancing BoNT production. Antibiotics with these properties may promote elimination of C. botulinum from the intestines while maintaining low levels of BoNT.

リンク情報
DOI
https://doi.org/10.1111/1348-0421.12928
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34219270
ID情報
  • DOI : 10.1111/1348-0421.12928
  • PubMed ID : 34219270

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